|Official Full Name||C-type lectin domain family 10, member A|
|Background||ASGPR/MGL (asialoglycoprotein / macrophage galactose lectin receptor) / CD301 is a Ca2+ dependent type II transmembrane lectin. Immunoprecipitation from DCs using anti-DC-ASGPR Monoclonal Antibody yields a major 40-kDa protein. ASGPR mRNA is observed predominantly in immune tissues (DCs and granulocytes), but not in T, B, or NK cells, or monocytes. ASGPR species are restricted to the CD14- derived DCs obtained from CD34+ progenitors, while absent from the CD1a-derived subset. Accordingly, both monocyte-derived DCs and tonsillar interstitial-type DCs express ASGPR protein, while Langerhans-type cells do not. ASGPR is a feature of immaturity, as its expression is lost upon CD40L activation. In agreement with the presence of tyrosine-based and dileucine motifs in the intracytoplasmic domain, Monoclonal Antibody against DC-ASGPR is rapidly internalized by DCs at 37°C. Finally, intracellular ASGPR is localized in early endosomes, suggesting that the receptor recycles to the cell surface following internalization of ligand. ASGPR/HML is a feature of immature DCs and a subtype of macrophages, and likely important for the specialized antigen-capture function of DCs.|
|Synonyms||HML; MGL; HML2; CD301; CLECSF13; CLECSF14; C-type lectin domain family 10 member A; macrophage lectin 2 (calcium dependent); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 13 (macrophage-derived); C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 14 (macrophage-derived); CD301 antigen; CLEC10A; C-type lectin superfamily member 14; Macrophage lectin 2; macrophage C-type lectin|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CLEC10A involved in several pathways and played different roles in them. We selected most pathways CLEC10A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
CLEC10A has several biochemical functions, for example, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC10A itself. We selected most functions CLEC10A had, and list some proteins which have the same functions with CLEC10A. You can find most of the proteins on our site.
|carbohydrate binding||CLEC10A; CD248; LMAN1L; KRT1; LGALS3L; FCN1; MAN2A1; LMAN2; CLEC6A; Fcer2a|
CLEC10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC10A here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC10A.