EZH2

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EZH2

Official Full Name enhancer of zeste homolog 2 (Drosophila)
Background This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Synonyms EZH2; enhancer of zeste homolog 2 (Drosophila); WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; histone-lysine N-methyltransferase EZH2; lysine N-methyltransferase 6;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EZH2-45H Recombinant Human EZH2 protein, His-tagged E.coli His
    Human EZH2-46H Recombinant Human EZH2 Protein, His-tagged E.coli His
    Human EZH2-47H Recombinant Human EZH2 protein, His-tagged E.coli His
    Mouse Ezh2-991M Recombinant Mouse Ezh2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human EZH2-161H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-162H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-163H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-164H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-165H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-166H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-167H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-169H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell His
    Human EZH2-170H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell His
    Human EZH2-171H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-172H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-173H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-174H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-175H Recombinant Human EZH2 protein, His-tagged Insect Cell His
    Human EZH2-176H Recombinant Human EZH2 protein, His-tagged Insect Cell His
    Human EZH2-177H Recombinant Human EZH2 Complex protein, His/GST-tagged Insect Cell His/GST
    Human EZH2-179H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-182H Recombinant Human EZH2(Y641C) protein, GST-tagged Insect Cell GST
    Human EZH2-183H Recombinant Human EZH2(Y641H) protein, GST-tagged Insect Cell GST
    Human EZH2-184H Recombinant Human EZH2(Y641N) protein, GST-tagged Insect Cell GST
    Human EZH2-285H Recombinant Human EZH2 Protein, GST-tagged Insect Cell GST
    Human EZH2-28H Recombinant Human EZH2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EZH2-29233TH Recombinant Human EZH2, His-tagged E.coli His
    Human EZH2-29H Recombinant Human EZH2 Protein, GST-tagged Wheat Germ GST
    Human EZH2-3948H Recombinant Human EZH2 Complex protein, His/Flag-tagged Insect Cell His/Flag
    Human EZH2-42H Recombinant Human EZH2 Protein, His-tagged E.coli His
    Human EZH2-542H Recombinant Human EZH2 Mammalian Cell His
    Human EZH2-6487HCL Recombinant Human EZH2 293 Cell Lysate HEK293 N/A
    Human EZH2-82H Recombinant Human EZH2 Complex protein, His-tagged Insect Cell Flag/His
    Human EZH2-998H Recombinant Human EZH2, His-GST-tagged Sf9 Insect Cell His/GST
    Rhesus Macaque EZH2-1528R Recombinant Rhesus monkey EZH2 Protein, His-tagged Mammalian Cell His
    Zebrafish EZH2-4654Z Recombinant Zebrafish EZH2 Mammalian Cell His
    Kit-1723 EZH2 (A677G) Chemiluminescent Assay Kit N/A
    Kit-1724 EZH2 (Y641F) Chemiluminescent Assay Kit N/A
    Kit-1725 EZH2 (Y641N) Chemiluminescent Assay Kit N/A
    Kit-1726 EZH2 Chemiluminescent Assay Kit N/A
    Kit-1727 EZH2 Homogeneous Assay Kit N/A

    EZH2 involved in several pathways and played different roles in them. We selected most pathways EZH2 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EZH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer DNMT3A; BMPR2; ERBB2; Pdgfa&Pdgfb; TRP63; TPM1; EFNA3; STMN1; NOTCH4; HDAC1

    EZH2 has several biochemical functions, for example, DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EZH2 itself. We selected most functions EZH2 had, and list some proteins which have the same functions with EZH2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding CERS5; CREB3; ZFAND5A; ETV5B; TRIM27; MEF2CB; HIST1H2BD; UHRF2; SRRT; BANP
    chromatin DNA binding EP300; ACTN4; HIST1H1A; INSM1B; H2AFY; MYOD1; HIST1H1B; VAX1; RXRA; FOXC2
    chromatin binding BAP1; NFKB1; C10orf119; HMGB2; GATA2; EZH1; KDM5A; REL; PHF21A; RFX4
    core promoter binding E2F7; GADD45A; MTF1; E2F8; HMGA2; MYOD1; EP300; HDAC5; FOXP3; REST
    histone methyltransferase activity PRDM13; CARM1; SUV39H1; PRMT6; PRMT2; PRMT1; EED; EZH2; SUZ12
    histone methyltransferase activity (H3-K27 specific) EHMT2; WHSC1L1; EZH2; EHMT1
    histone-lysine N-methyltransferase activity PRDM2; SETD7; EHMT1B; SETDB1A; WHSC1L1; SUV39H1A; SETD8; SUV39H1B; EZH1; EHMT1
    protein binding ZNF223; WDR92; DIRAS3; TIPIN; MPPE1; CD163; PTTG1; PSMD9; RPS11; SULT2A1
    protein-lysine N-methyltransferase activity PRMT8B; METTL21C; TRMT10C; METTL8; EZH2; SETD4; RNMTL1B; IRF4; FAM86A; TRMT10B

    EZH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EZH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EZH2.

    SUZ12; EED

    Alberghini, F; Petrocelli, V; et al. An epigenetic view of B-cell disorders. IMMUNOLOGY AND CELL BIOLOGY 93:253-260(2015).
    Floris, I; Descamps, B; et al. Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:664-674(2015).

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