ezh2
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  • Official Full Name
  • enhancer of zeste homolog 2 (Drosophila)
  • Background
  • This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
  • Synonyms
  • EZH2; enhancer of zeste homolog 2 (Drosophila); WVS; ENX1; EZH1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; histone-lysine N-methyltransferase EZH2; lysine N-methyltransferase 6;
Cat.#:EZH2-285HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human EZH2 Protein, GST-tagged
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Cat.#:EZH2-161HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-162HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-163HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-164HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-165HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-166HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-167HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-169HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His-tagged
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Cat.#:EZH2-170HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His-tagged
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Cat.#:EZH2-171HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-172HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-173HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-174HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-175HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 protein, His-tagged
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Cat.#:EZH2-176HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 protein, His-tagged
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Cat.#:EZH2-177HTag:His/GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/GST-tagged
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Cat.#:EZH2-179HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-182HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2(Y641C) protein, GST-tagged
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Cat.#:EZH2-183HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2(Y641H) protein, GST-tagged
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Cat.#:EZH2-184HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2(Y641N) protein, GST-tagged
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Cat.#:EZH2-28HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human EZH2 Protein, MYC/DDK-tagged
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Cat.#:EZH2-29233THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EZH2, His-tagged
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Cat.#:EZH2-29HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human EZH2 Protein, GST-tagged
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Cat.#:EZH2-3948HTag:His/Flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His/Flag-tagged
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Cat.#:EZH2-42HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human EZH2 Protein, His-tagged
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Cat.#:EZH2-542HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human EZH2
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Cat.#:EZH2-82HTag:Flag/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human EZH2 Complex protein, His-tagged
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Cat.#:EZH2-998HTag:His/GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human EZH2, His-GST-tagged
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Cat.#:EZH2-1528RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey EZH2 Protein, His-tagged
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Cat.#:EZH2-4654ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish EZH2
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Cat.#:EZH2-6487HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human EZH2 293 Cell Lysate
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Cat.#:Kit-1723Tag:
Source (Host):Species:
Product nameEZH2 (A677G) Chemiluminescent Assay Kit
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Cat.#:Kit-1724Tag:
Source (Host):Species:
Product nameEZH2 (Y641F) Chemiluminescent Assay Kit
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Cat.#:Kit-1725Tag:
Source (Host):Species:
Product nameEZH2 (Y641N) Chemiluminescent Assay Kit
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Cat.#:Kit-1726Tag:
Source (Host):Species:
Product nameEZH2 Chemiluminescent Assay Kit
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Cat.#:Kit-1727Tag:
Source (Host):Species:
Product nameEZH2 Homogeneous Assay Kit
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Involved Pathway

EZH2 involved in several pathways and played different roles in them. We selected most pathways EZH2 participated on our site, such as MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with EZH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MicroRNAs in cancer
RHOA; FGFR3; TRIM71; GRB2; TGFB2; SHC1; RDX; IKBKB; APC; CCNE1

Protein Function

EZH2 has several biochemical functions, for example, DNA binding, chromatin DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EZH2 itself. We selected most functions EZH2 had, and list some proteins which have the same functions with EZH2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SSH3; HIF1AL; ZFP326; TFDP3; ZIM2; PAX7B; CDT1; MTF2; SOX12; HOXA1A
Function chromatin DNA binding
Related Protein THRB; GRHL2; ATOH1; WBP2; PRDM14; MYOG; SMAD3; PER1; HIST1H1D; GRHL3
Function chromatin binding
Related Protein REST; SSBP1; PRDM11; LOXL2; SATB1; NR5A5; EOMES; HINFP; BEND6; LMO2
Function core promoter binding
Related Protein DHX36; REST; MYOG; HDAC5; HDAC2; AGO2; SAFB; HMGA2; INSM1B; AGO1
Function histone methyltransferase activity
Related Protein EED; PRMT1; PRMT2; SUZ12; PRDM13; PRMT6; SUV39H1; EZH2; CARM1
Function histone methyltransferase activity (H3-K27 specific)
Related Protein EHMT2; WHSC1L1; EZH2; EHMT1
Function histone-lysine N-methyltransferase activity
Related Protein SUV420H1; SETD1B; MLL5; SETDB1; PRDM9; WHSC1L1; PRDM6; AAAS; EHMT1B; SETD1BA
Function protein binding
Related Protein ARPC5; MAP4K4; NFKBIE; UPK3A; PINX1; TSPAN15; NR1H3; RAD50; IL18R1; QRICH1
Function protein-lysine N-methyltransferase activity
Related Protein RNMTL1A; PRMT8B; SETD8; VCPKMT; METTL7B; METTL21C; TRMT10B; IRF4; NDUFAF5; SETD4

Interacting Protein

EZH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EZH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EZH2.
SUZ12; EED

EZH2 Related Articles

Alberghini, F; Petrocelli, V; et al. An epigenetic view of B-cell disorders. IMMUNOLOGY AND CELL BIOLOGY 93:253-260(2015).
Floris, I; Descamps, B; et al. Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:664-674(2015).