Recombinant Human EZH2 Protein, GST-tagged

• Cat.No.: EZH2-285H
• Product Overview: Recombinant full-length human EZH2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: EZH2 (enhancer of zeste homolog 2) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH2 expression is associated with proliferating tissues and shares an overlapping set of target genes with EZH1. Compared to PRC2-EZH1, PRC2-EZH2 exhibits higher levels of histone methyltransferase (HKMT) activity.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~130 kDa
• Purity: > 85%
• Storage: Store product at -70 centigrade.
• Concentration: 0.05ug/uL
• Publication:
  Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiationrelated genes to promote self-renewal (2023)

Gene Information

• Gene Name: EZH2 enhancer of zeste homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: EZH2
• Synonyms: EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A; lysine N-methyltransferase 6; ENX1; WVS2; ENX-1; MGC9169
• Gene ID: 2146
• mRNA Refseq: NM_001203247
• Protein Refseq: NP_001190176
• MIM: 601573
• UniProt ID: Q15910

Reviews

10/17/2022

The versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.

03/14/2018

In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.

02/27/2018

Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.

Q&As

How is EZH2 overexpression associated with cancer progression?

EZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.

Are there any non-oncological clinical applications of EZH2?

EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.

What are the potential side effects of EZH2 inhibitors in clinical use?

Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.

How can EZH2 be targeted for cancer therapy?

Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.

Are there any prognostic implications of EZH2 expression in cancer patients?

High EZH2 expression has been associated with poor prognosis in several cancer types.