Recombinant Human EZH2(Y641C) protein, GST-tagged
Cat.No. : | EZH2-182H |
Product Overview : | Recombinant Human EZH2(Y641C) fused with GST tag at N-terminal was expressed in Insect cells. |
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Description : | EZH2 (enhancer of zeste homolog 2) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH2 expression is associated with proliferating tissues and shares an overlapping set of target genes with EZH1. Compared to PRC2-EZH1, PRC2-EZH2 exhibits higher levels of histone methyltransferase (HKMT) activity. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | 130 kDa |
Purity : | >75% |
Applications : | Methyltransferase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | EZH2 enhancer of zeste homolog 2 (Drosophila) [ Homo sapiens ] |
Official Symbol : | EZH2 |
Synonyms : | EZH2; enhancer of zeste homolog 2 (Drosophila); enhancer of zeste (Drosophila) homolog 2; histone-lysine N-methyltransferase EZH2; ENX 1; EZH1; KMT6; KMT6A; lysine N-methyltransferase 6; ENX1; WVS2; ENX-1; MGC9169; |
Gene ID : | 2146 |
mRNA Refseq : | NM_001203247 |
Protein Refseq : | NP_001190176 |
MIM : | 601573 |
UniProt ID : | Q15910 |
Chromosome Location : | 7q35-q36 |
Function : | DNA binding; histone methyltransferase activity; histone-lysine N-methyltransferase activity; methyltransferase activity; protein binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
Ezh2-991M | Recombinant Mouse Ezh2 Protein, MYC/DDK-tagged | +Inquiry |
EZH2-46H | Recombinant Human EZH2 Protein, His-tagged | +Inquiry |
EZH2-5744H | Recombinant Human EZH2 protein, His-tagged | +Inquiry |
EZH2-1353R | Recombinant Rhesus Macaque EZH2 Protein, His (Fc)-Avi-tagged | +Inquiry |
EZH2-285H | Recombinant Human EZH2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
EZH2-6487HCL | Recombinant Human EZH2 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1724 | EZH2 (Y641F) Chemiluminescent Assay Kit | +Inquiry |
Kit-1726 | EZH2 Chemiluminescent Assay Kit | +Inquiry |
Kit-1727 | EZH2 Homogeneous Assay Kit | +Inquiry |
Kit-1725 | EZH2 (Y641N) Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe versatility of the EZH2 protein is truly remarkable, as it can be employed across a wide range of applications in my research.
In addition to its outstanding quality, the manufacturer of the EZH2 protein offers excellent technical support that can effectively address any challenges I may encounter.
Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the EZH2 protein into my experimental setup.
Q&As (5)
Ask a questionEZH2 overexpression is associated with promoting tumor cell proliferation, invasion, and metastasis, leading to cancer progression.
EZH2 has been implicated in various non-oncological conditions, including cardiovascular diseases and neurodegenerative disorders.
Potential side effects may include hematological toxicity, gastrointestinal issues, and liver enzyme elevation.
Small molecule inhibitors of EZH2 have been developed and are being investigated as potential cancer therapies.
High EZH2 expression has been associated with poor prognosis in several cancer types.
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