fas
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  • Official Full Name
  • Fas cell surface death receptor
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
  • Synonyms
  • FAS; Fas cell surface death receptor; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
Cat.#:FAS-3850HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FAS Protein
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Cat.#:FAS-3851HTag:His/Flag/StrepII
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FAS Protein, His/Flag/StrepII-tagged
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Cat.#:FAS-3853HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FAS Protein, GST-tagged
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Cat.#:FAS-5411HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fas (TNF receptor superfamily, member 6)
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Cat.#:Fas-026HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human Fas Protein, Fc-tagged
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Cat.#:Fas-027HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human Fas Protein, His-tagged
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Cat.#:FAS-12751HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS, GST-tagged
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Cat.#:FAS-16HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS protein, MYC/DDK-tagged
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Cat.#:FAS-239HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS, Fc-tagged
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Cat.#:FAS-26332THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS protein
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Cat.#:FAS-27896THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS, His-tagged
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Cat.#:FAS-281HTag:His/GST
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS, His & GST tagged
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Cat.#:FAS-3154HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS, His tagged
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Cat.#:FAS-37HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human Fas Ligand Inhibitor, Fc-tagged
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Cat.#:FAS-3814HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fas (TNF receptor superfamily, member 6)
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Cat.#:FAS-38HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fas Ligand soluble, FLAG-tagged
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Cat.#:FAS-4270HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fas (TNF Receptor Superfamily, Member 6)
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Cat.#:FAS-519HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS
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Cat.#:FAS-602HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS protein, Fc-tagged
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Cat.#:FAS-603HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FAS, Fc-tagged, Biotinylated
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Cat.#:FAS-614HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS protein, His-tagged
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Cat.#:FAS-615HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS protein, His & GST-tagged
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Cat.#:FAS-616HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FAS protein, His & MBP-tagged
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Cat.#:Fas-3268MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fas, His tagged
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Cat.#:Fas-617MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fas protein, His-tagged
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Cat.#:Fas-618MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Fas protein, His-tagged
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Cat.#:FAS-2273RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FAS Protein
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Cat.#:Fas-4096RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fas, His tagged
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Cat.#:Fas-486RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Fas protein, His-tagged
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Cat.#:FAS-547RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Fas, Fc tagged
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Cat.#:Fas-620RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fas protein, His & GST-tagged
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Cat.#:Fas-622RTag:His/MBP
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fas protein, His & MBP-tagged
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Cat.#:Fas-823RTag:Fc
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Fas Protein, Fc Chimera
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Cat.#:FAS-142CTag:His/GST
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FAS, Fc tagged
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Cat.#:FAS-203CTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FAS
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Cat.#:FAS-513CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FAS Protein, His-tagged
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Cat.#:FAS-1644RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FAS Protein, His-tagged
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Cat.#:FAS-4338CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FAS
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Cat.#:FAS-613CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle FAS protein, His & T7-tagged
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Cat.#:FAS-619PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig FAS protein, His & GST-tagged
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Cat.#:FAS-635FTag:Fc Chimera
Source (Host):NSO cellsSpecies:Feline
Product nameRecombinant Feline FAS, Fc Chimera
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Cat.#:FAS-5265HTag:N/A
Source (Host):Human embryo kidney cellsSpecies:Human
Product nameRecombinant Human Fas (TNF receptor superfamily, member 6)
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Cat.#:FAS-1615HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fas (TNF Receptor Superfamily, Member 6)
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Cat.#:Fas-1735MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Fas (TNF Receptor Superfamily Member 6)
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Cat.#:FAS-1411HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Fas (TNF Receptor Ssuper Family, Member 6)
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Cat.#:FAS-2185HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FAS cell lysate
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Cat.#:FAS-2419MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FAS cell lysate
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Cat.#:FAS-1139RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat FAS cell lysate
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Cat.#:FAS-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus FAS cell lysate
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Cat.#:CDA074PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-95, His Tag
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Cat.#:CDA093PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD95
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Involved Pathway

FAS involved in several pathways and played different roles in them. We selected most pathways FAS participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
HSP70L; ARR3B; PDGFAB; FGF6B; CACNA1G; TAOK1; GRB2A; CDC25B; RPS6KA1; NF1
Cytokine-cytokine receptor interaction
CX3CL1; BMP2; PDGFB; IL4; MET; IL6R; CCL11; IL1A; IL15; CCR9A
p signaling pathway
APAF1; SERPINE1; FAS; MDM2; CCND2A; CCNB2; LRDD; TRP53; CCNB1; SHISA5
Apoptosis
PIK3R3B; CAPN2B; PIK3R1; HELLS; CAPN1B; DBNL; BMX; PRKAR2B; CASP8L1; IRAK4
Natural killer cell mediated cytotoxicity
MAP2K1; ICAM2; SYK; Raet1a; PTK2B; FAS; ULBP3; RAC1; NCR1; IFNA1
TNF signaling pathway
PTGS2; PIK3CA; MAP3K7IP3; MMP3; MAP2K6; Ccl12; TRADD; BIRC2; MMP9; BIRC3
Non-alcoholic fatty liver disease (NAFLD)
NDUFA3; PKLR; PRKAG2; ATF4; FAS; Il6ra; IRS1; PIK3R1; MAP3K5; NDUFB10
Type I diabetes mellitus
ICA1; TNF; HLA-G; IL1B; GAD1; HLA-C; GAD2; PRF1; HLA-DQA2; CD80
Alzheimers disease
COX6B2; BACE1; NDUFA4; UQCRB; NDUFA12; NDUFV2; PLCB1; PSEN2; LRP1; SNCA
Chagas disease (American trypanosomiasis)
IL10; CCL3L3; GNAQ; FOS; IL6; PPP2R2C; NFKBIA; MAPK11; IL1B2; MAPK9
African trypanosomiasis
VCAM1; IL1B; TLR9; IL1B2; Fasl; HBA1; IL12A; PRKCG; PLCB2; PRKCB
Hepatitis B
FOS; MAP2K4; CREB3L1; IFNA5; NFATC3; MMP9; CCNA1; FAS; STAT3; RB1
Measles
IL1B; PIK3CD; IFNA10; BBC3; TNFRSF10B; Cd209g; CCND2; EIF2AK2; RCHY1; IFNA2
Influenza A
NFKBIA; IFNAR1; OAS1; GSK3B; IFNA6; EIF2AK3; IFNA21; HLA-DRB3; PRSS2; OAS1A
Herpes simplex infection
CUL1B; CYCS; TRAF5; SRSF4; EIF2AK2; MAPK10; MHC2DCB; IFNAR2; RELA; BLB2
Pathways in cancer
FGF21; IL6; ROCK2; WNT5B; DAPK1; GLI2; FLT3LG; FGF17; LPAR4; PLEKHG5
Proteoglycans in cancer
TGFB1; ROCK2; HSPG2; WNT5B; WNT3A; WNT6; PRKACA; ELK1; Fzd4; ITGB3
Autoi
TG; TSHR; HLA-DRB1; IFNA1; CD80; HLA-E; Ifna15; CD40; FAS; H2-AB1
ne thyroid disease
IFNA12; TSHB; FAS; IFNA21; IFNA16; IFNA10; GZMB; HLA-DMA; IFNA4; HLA-DRB4
Allograft rejection
HLA-DQA2; IL10; HLA-DOA; HLA-DMA; HLA-DRB1; HLA-B; FASLG; HLA-A; HLA-DOB; FAS
Graft-versus-host disease
KIR2DL3; HLA-DPB1; HLA-DQB1; KLRC1; FAS; H2-Q10; HLA-A; HLA-DOB; HLA-E; HLA-DMB

Protein Function

FAS has several biochemical functions, for example, identical protein binding, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FAS itself. We selected most functions FAS had, and list some proteins which have the same functions with FAS. You can find most of the proteins on our site.
Function
Related Protein
Function identical protein binding
Related Protein LRRK1; USP15; SMURF2; ALDOA; DHX8; LDHB; C1QTNF6; GNPNAT1; POLG2; SERPINA1E
Function kinase binding
Related Protein PARK7; HSP90AB1; PPP2R5A; EMP2; CDC6; CTNNB1; TRADD; WWC2; PFKL; SLC2A1
Function protein binding
Related Protein SEC61G; NEK8; ZBTB7C; SPANXD; DDX11; TFDP2; SAP30L; SPCS1; GAL; ICAM3
Function receptor activity
Related Protein EPHB6; IL10RA; KRT1; CRLF1; NOTCH4; NLGN1; GABRA5; CD200; LDLR; LILRA3
Function signal transducer activity
Related Protein GPR177; CXCR3.2; CD24; MRGPRA7; GNA14; V2RX1; STAT5B; ADRA2DB; OPRD1A; MAPKAPK5
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSFA; TNFRSF6B; FAS; TNFRSF4; TNFRSF1A; TNFRSF18; EDA2R; CD27; RELT; NGFR

Interacting Protein

FAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FAS here. Most of them are supplied by our site. Hope this information will be useful for your research of FAS.
FADD

FAS Related Articles

Choi, BD; Jeong, SJ; et al. The Effect of Thymosin beta 4 for Osteoblast Adhesion on Titanium Surface. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5663-5667(2015).
Rutkowska, J; Bialek, M; et al. Differentiation of geographical origin of cream products in Poland according to their fatty acid profile. FOOD CHEMISTRY 178:26-31(2015).