Active Recombinant Feline FAS, Fc Chimera

• Cat.No.: FAS-635F
• Product Overview: Recombinant Feline FAS (Accession # NP_001009314) was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Feline
• Tag: Fc
• Predicted N Terminal: Ala25
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells.The ED50 for this effect is typically 1 - 4 µg/mL in the presence of 20 ng/mL of rhFas Ligand.
• Molecular Mass: Recombinant Feline FAS, Fc Chimera has a calculated MW of 43 kDa (monomer). In SDS-PAGE migrates as 59-61 kDa, reducing conditions.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: FAS Fas cell surface death receptor [ Felis catus (domestic cat) ]
• Official Symbol: FAS
• Synonyms: FAS; Fas cell surface death receptor; TNFRSF6; tumor necrosis factor receptor superfamily member 6; Fas (TNF receptor superfamily, member 6); Fas antigen; tumor necrosis factor receptor superfamily, member 6
• Gene ID: 493881
• mRNA Refseq: NM_001009314
• Protein Refseq: NP_001009314
• Chromosome Location: D2

Reviews

09/07/2022

When experimenting with FAS, the results are very reproducible.

07/29/2022

The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

09/20/2021

FAS has high specific activity and can exert strong biological effect at low concentration.

Q&As

Does FAS protein play a role in cell signaling?

FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

Why apply knowledge of FAS proteins to clinical practice?

It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

How can diseases associated with FAS protein be prevented and treated?

FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

How can gene knockout or knockdown techniques be used to study the function of FAS proteins?

Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

What is the role of FAS protein in apoptosis?

FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

How can FAS protein be used to predict disease prognosis?

The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.