Recombinant Human Fas (TNF Receptor Ssuper Family, Member 6)

• Cat.No.: FAS-1411H
• Product Overview: Recombinant, human soluble APO-1/Fas:Fc-IgG (aa.1-154) is produced in human embryo kidney cells. MW= 60 kDa.

Specification

• Cat. No.: FAS-1411H
• Description: Apo-1 (Fas/CD95) is a 45 kD type I transmembrane protein belonging to the TNF receptor family. A subgroup of this receptor family called ”death receptors” contain 3-4 cysteine-rich repeats in the extracellular portion and a cystoplasmic motif called the ”death domain”, which is responsible for the transduction of the death signal. The death domain associates with FADD/MORT, which in turn connects to aspartate-specific proteases (Caspases) that are implicated as mediators of most types of apoptotic cell death (6-9).
• Source: Human embryo kidney cells.
• Presentation And Handling: sAPO-1/Fas is provided as lyophilized powder. Prepare a concentrated stock solution of APO-1/Fas:Fc-IgG (1 mg/ml in PBS) by dissolving the entire preparation (50 µg) in 50 µl sterile H₂O. Further dilutions should be made with medium containing 5% fetal calf serum.
• Purity: >95% pure as demonstrated by SDS-PAGE.
• Biological Activity: Recombinant, human soluble APO-1/Fas:Fc-IgG inhibits the activity of APO-1/Fas ligand of human and mouse.

Gene Information

• Gene Name: FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ]
• Synonyms: FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily, member 6; Fas AMA; CD95 antigen; apoptosis antigen 1; APO-1 cell surface antigen
• Gene ID: 355
• mRNA Refseq: NM_000043
• Protein Refseq: NP_000034
• MIM: 134637
• UniProt ID: P25445
• Chromosome Location: 10q24.1
• Pathway: Allograft rejection; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; MAPK signaling pathway; Natural killer cell mediated cytotoxicity; Type I diabetes mellitus; Apoptosis
• Function: identical protein binding; kinase binding; transmembrane receptor activity