Recombinant Human FAS, His & GST tagged

Cat.No. : FAS-281H
Product Overview : Recombinant Human FAS extracellular domain (Met 1-Glu 173) (NP_000034.1), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cell.
Availability July 19, 2024
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Source : Human Cells
Species : Human
Tag : His&GST
Form : Lyophilized from sterile PBS, pH 7.4
Molecular Mass : The recombinant human Fas/Fc chimera is a disulfide-linked homodimeric protein generated after removal of the signal peptide. The reduced monomer consists of 386 amino acids and has a predicted molecular mass of 43.4 kDa. In SDS-PAGE under reducing conditions, the monomer migrates as an approximately 55-60 kDa protein due to glycosylation.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Publication :
Soluble Fas affects erythropoiesis in vitro and acts as a potential predictor of erythropoiesis-stimulating agent therapy in patients with chronic kidney disease (2020)
Gene Name : FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ]
Official Symbol : FAS
Gene ID : 355
mRNA Refseq : NM_000043
Protein Refseq : NP_000034
MIM : 134637
UniProt ID : P25445

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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09/07/2022

    When experimenting with FAS, the results are very reproducible.

    07/29/2022

      The stability of FAS products allows them to cope with different experimental conditions and modes of operation.

      09/20/2021

        FAS has high specific activity and can exert strong biological effect at low concentration.

        Q&As (6)

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        Does FAS protein play a role in cell signaling? 10/30/2022

        FAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.

        Why apply knowledge of FAS proteins to clinical practice? 06/27/2022

        It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.

        How can diseases associated with FAS protein be prevented and treated? 05/13/2022

        FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.

        How can gene knockout or knockdown techniques be used to study the function of FAS proteins? 03/31/2021

        Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.

        What is the role of FAS protein in apoptosis? 09/29/2020

        FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.

        How can FAS protein be used to predict disease prognosis? 06/19/2020

        The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.

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