FCGR2A
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Official Full Name
Fc fragment of IgG, low affinity IIa, receptor (CD32)
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Overview
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. -
Synonyms
FCGR2A; Fc fragment of IgG, low affinity IIa, receptor (CD32); CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Cynomolgus Monkey
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO
- Cynomolgus
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse myeloma cell
- Wheat Germ
- C
- His
- Fc
- Flag
- GST
- hFc
- His (Fc)
- Avi
- His|Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FCGR2A Related Articles
FCGR2A involved in several pathways and played different roles in them. We selected most pathways FCGR2A participated on our site, such as Phagosome, Osteoclast differentiation, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | SCARB1;BF1;TUBA3A;HGS;TUBA1C;HLA-DQA1;HLA-C;TFRC;HLA-DRB4 |
Osteoclast differentiation | LILRB4;PPP3R1;PIK3R2;SIRPG;TNFRSF1A;NCF2;FCGR3B;CYLD;FCGR4 |
Platelet activation | VWF;MYLK2;PLA2G4C;F2R;MYL12B;PIK3R5;MAPK13;PPP1CB;PLCB4 |
Fc gamma R-mediated phagocytosis | PLCG1;FCGR2A;FCGR1;LIMK1;FCGR2B;SYK;VAV3;PAK1;GAB2 |
Leishmaniasis | FCGR4;IRAK4;NCF1;FCGR3A;TGFB3;PRKCB;FCGR1;FCGR2C;IL1A |
Staphylococcus aureus infection | cgr2b;ITGAL;FCGR3B;GM5077;HLA-DRB5;FCGR4;Hc;C2;C1R |
Tuberculosis | MAPK13;IFNA17;IFNA7;ATP6V0A2;IFNA21;CAP18;CARD9;CAMK2A;LSP1 |
Systemic lupus erythematosus | HIST1H4F;C1R;C1QA;HIST1H3E;H2-AB1;HIST1H2AE;HIST1H2AP;HIST2H2BB;HLA-DRA |
FCGR2A has several biochemical functions, for example, IgG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR2A itself. We selected most functions FCGR2A had, and list some proteins which have the same functions with FCGR2A. You can find most of the proteins on our site.
Function | Related Protein |
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IgG binding | FCGR2C;FCGR1;FCGRT;CD247L;UMOD;PIP;cgr2b;FCGR3A;FCGR1B |
protein binding | P4HB;ACAP1;INCENP;LTBP2;SERPINC1;TNFAIP8L2;SLC4A4;EME1;PMAIP1 |
FCGR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR2A.
UBQLN1; UBQLN1; drozitumab; CRP; SYK
- Q&As
- Reviews
Q&As (5)
Ask a questionFCGR2A may influence the risk and severity of allergic reactions by modulating the immune response to allergens and antibodies involved in allergic processes.
FCGR2A participates in host defense against infectious diseases by facilitating the recognition and clearance of pathogens through antibody-mediated immune responses.
FCGR2A contributes to the understanding of immunogenetics by highlighting the genetic factors that influence immune responses and the development of immune-related diseases.
Genetic variations in FCGR2A can influence an individual's response to immunotherapy by affecting the affinity of FCGR2A for antibodies, thereby modulating immune cell activation.
FCGR2A can be targeted for therapeutic interventions through the development of drugs that modulate its activity, offering potential strategies for treating immune-related disorders.
Customer Reviews (3)
Write a reviewWith its purity and reliability, this protein is poised to contribute significantly to the success of my research objectives by providing accurate and reproducible results.
Its versatility allows for exploration of its extensive involvement in various biochemical and biological processes, providing valuable insights into its role and implications.
The FCGR2A Protein demonstrates remarkable stability and functional efficiency, making it an indispensable tool for diverse scientific applications.
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