FGFR2 Protein, fibroblast growth factor receptor 2

FGFR2

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FGFR2

Official Full Name fibroblast growth factor receptor 2
Background The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.
Synonyms FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus monkey
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Spodoptera Frugiperda
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • Fc Chimera
    • GST
    • hIgG1
    • hIgG4
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Fgfr2-726M Recombinant Mouse Fgfr2 protein E.coli N/A
    Human FGFR2-02H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc-tagged Insect Cell Fc
    Human FGFR2-102H Recombinant Human Fibroblast Growth Factor Insect Cell N/A
    Human FGFR2-18H Recombinant Human FGFR2 protein, GST-tagged Insect Cell GST
    Human FGFR2-2055H Recombinant Human FGFR2 Protein, DDK-tagged Insect Cell DDK
    Human FGFR2-2578HCL Recombinant Human FGFR2 cell lysate Human Cell N/A
    Human FGFR2-28889TH Recombinant Human FGFR2 N/A
    Human FGFR2-31452TH Recombinant Human FGFR2, Fc-tagged Fc
    Human FGFR2-314H Recombinant Human FGFR2, GST-tagged, Active Sf9 Insect Cell GST
    Human FGFR2-4128H Recombinant Human FGFR2 Protein Wheat Germ N/A
    Human FGFR2-4130H Recombinant Human FGFR2 Protein, GST-tagged Wheat Germ GST
    Human FGFR2-428HCL Recombinant Human FGFR2 cell lysate Insect Cell N/A
    Human FGFR2-481H Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Fc Chimera
    Human FGFR2-488H Recombinant Human Fibroblast Growth Factor Receptor 2 Sf21 Insect Cell N/A
    Human FGFR2-489H Recombinant Human Fibroblast Growth Factor Receptor 2 NSO N/A
    Human FGFR2-5002H Recombinant Human Fibroblast Growth Factor Receptor 2 Human N/A
    Human FGFR2-5418H Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged Insect Cell his
    Human FGFR2-595H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera E.coli Fc
    Human FGFR2-607H Recombinant Human FGFR2, His-tagged, Biotinylated Human Cell His
    Human FGFR2-608H Recombinant Human FGFR2, Fc-tagged, Biotinylated Human Cell Fc
    Human FGFR2-621H Recombinant Human FGFR2, His tagged Human Cell His
    Human FGFR2-690H Recombinant Human FGFR2, Fc Chimera NS0 Fc Chimera
    Human FGFR2-691H Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Fc Chimera
    Human FGFR2-705H Recombinant Human FGFR2, Fc-His tagged Human Cell Fc/His
    Human FGFR2-7303H Recombinant Human FGFR2, His & GST tagged Insect Cell His/GST
    Human FGFR2-777H Recombinant Human FGFR2 Protein, Fc-tagged HEK293 Fc
    Human FGFR2-778H Recombinant Human FGFR2 Protein, His-tagged HEK293 His
    Human FGFR2-791H Recombinant Human FGFR2 Protein, DDK/His-tagged HEK293 DDK/His
    Human FGFR2-821H Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell GST
    Human FGFR2-82H Recombinant Human FGFR2, MYC/DDK-tagged HEK293 Myc/DDK
    Human FGFR2-86H Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell GST
    Human FGFR2-87H Recombinant Human FGFR2, His-tagged E.coli His
    Mouse FGFR2-001MCL Recombinant Mouse FGFR2 cell lysate Human Cell N/A
    Mouse Fgfr2-368M Recombinant Mouse Fgfr2, Fc Chimera Sf21 Insect Cell Fc Chimera
    Mouse Fgfr2-427M Recombinant Mouse Fgfr2, Fc Chimera NS0 Fc Chimera
    Mouse Fgfr2-501M Recombinant Mouse Fgfr2, Fc-tagged Human Cell Fc
    Mouse Fgfr2-502M Recombinant Mouse Fgfr2, His-tagged Human Cell His
    Mouse Fgfr2-542M Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged Spodoptera Frugiperda Fc
    Mouse Fgfr2-551M Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged NS0 Fc
    Mouse Fgfr2-638M Recombinant Mouse Fgfr2 Protein, Fc Chimera NS0 Fc
    Rhesus monkey FGFR2-1752R Recombinant Rhesus Monkey FGFR2 Protein HEK293 N/A
    Rhesus monkey FGFR2-1753R Recombinant Rhesus Monkey FGFR2 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey FGFR2-1754R Recombinant Rhesus Monkey FGFR2 Protein, hIgG4-tagged HEK293 hIgG4
    Chicken FGFR2-6871C Recombinant Chicken FGFR2 Mammalian Cell His
    Zebrafish FGFR2-8029Z Recombinant Zebrafish FGFR2 Mammalian Cell His
    Kit-0341 FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A

    FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF13A; MAPK12B; MAP2K4B; PLA2G4C; CDC42L; MKNK2A; MEF2CB; JIP1; CACNA1H; FGF13
    Ras signaling pathway FGF2; FIGF; RAF1; RASSF5; PAK1; AKT1; PRKCB; RHOA; PLCG2; FLT4
    Rap signaling pathway FGF10; PFN2; FGF4; PIK3CD; FGF18; MRAS; GNAS; LPAR3; SIPA1L2; MAGI1
    Endocytosis BC2; NEDD4; CHMP5B; ARAP1; ACAP1; EHD1A; SNX1; CAPZA1; GRK7; WASB
    PIK-Akt signaling pathway IFNA14; GNB1; ITGA7; GNG12; EPO; CASP9; ITGA3; GNG13; IL6; IFNA10
    Signaling pathways regulating pluripotency of stem cells WNT3; ONECUT1; FGF2; LEFTY2; PCGF6; LIF; WNT9A; WNT2B; WNT4; FZD9
    Regulation of actin cytoskeleton PIP5K1AB; FGF22; ARHGEF1; CFL2L; RHOAC; ITGA3B; FGF8; ITGB3; CDC42L2; PDGFB
    Pathways in cancer FASLG; MECOM; FH; TGFA; PIK3CA; FZD7; HGF; PLCG2; ZBTB16; TRAF4
    Prostate cancer PDGFRB; EP300; LEF1; PIK3R5; BRAF; HSP90AA1; GSTP1; GRB2; RB1; MAP2K2
    Central carbon metabolism in cancer ERBB2; G6PD; MAP2K2; PFKL; TP53; SLC2A1; RAF1; IDH1; PIK3CB; RET

    FGFR2 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MLH3; PKDCC; ACTC1; STRC; EIF2B2; ULK1; TNK1; HELB; TOR2A; ADCK3
    fibroblast growth factor binding FGFR1A; SCN5A; FGFBP3; HSPA9; FGFR3; THBS1; RPS19; GLG1B; FIBPA; Api5
    fibroblast growth factor-activated receptor activity FGFR4; FGFR3; FGFR2; FGFRL1; FGFR1A; FGFR1; FGFR1B
    heparin binding WISP2; FSTL1; GREM2; Itgam&Itgb2; FN1; VEGFAB; PCSK6; RSPO4; VTN; ADAMTS3
    protein binding PAPD4; SH3GL2; RHPN1; CD8A; SLC38A2; RNF43; FAM83A; AMHR2; EXOC3; AMY1A
    protein homodimerization activity NUDT21; CCDC103; TYW5; PLOD1; SETMAR; SPATA24; BCL2L1; CRYBA2; GAMT; CCBL1
    protein tyrosine kinase activity INSR; KDR; ZNF143B; SRC; KDRL; BAZ1B; ERBB3A; TNK2B; JAK1; CLK3

    FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.

    FGF1; ssr; GRB2; FGF2; FGF10

    De Vita, F; Di Martino, N; et al. Clinical management of advanced gastric cancer: The role of new molecular drugs. WORLD JOURNAL OF GASTROENTEROLOGY 20:14537-14558(2014).
    Zhang, Y; Pan, TC; et al. Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression. JOURNAL OF PHARMACOLOGICAL SCIENCES 126:77-83(2014).

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