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FGFR2

  • Official Full Name

    fibroblast growth factor receptor 2

  • Overview

    The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.
  • Synonyms

    FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus monkey
  • Xenopus laevis (African clawed frog)
  • Zebrafish
  • Baculovirus-Infected Sf9 Cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Spodoptera Frugiperda
  • Wheat Germ
  • C
  • His
  • hFc
  • DDK
  • DDK|His
  • Fc
  • Fc Chimera
  • His(C
  • ter)
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • his
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGFR2-18H Active Recombinant Human FGFR2 protein, GST-tagged Insect Cell GST
Human FGFR2-607H Active Recombinant Human FGFR2, His-tagged, Biotinylated Human Cell His
Human FGFR2-481H Active Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Fc Chimera
Human FGFR2-690H Active Recombinant Human FGFR2, Fc Chimera Mammalian cells Fc Chimera
Human FGFR2-821H Active Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell GST 285-end
Human FGFR2-608H Active Recombinant Human FGFR2, Fc-tagged, Biotinylated Human Cell Fc
Human FGFR2-691H Active Recombinant Human FGFR2, Fc Chimera Sf21 Insect Cell Fc Chimera
Human FGFR2-86H Active Recombinant Human FGFR2, GST-tagged Sf9 Insect Cell GST
Human FGFR2-705H Active Recombinant Human FGFR2 protein(Met1-Glu377), His&hFc-tagged HEK293 C-His&hFc Met1-Glu377
Human FGFR2-102H Recombinant Human Fibroblast Growth Factor Insect Cell N/A
Human FGFR2-777H Recombinant Human FGFR2 Protein, Fc-tagged HEK293 Fc
Human FGFR2-7303H Active Recombinant Human FGFR2 protein, His&GST-tagged Insect Cells His/GST Met400-Thr821
Human FGFR2-314H Recombinant Human FGFR2, GST-tagged, Active Sf9 Insect Cell GST
Human FGFR2-31452TH Recombinant Human FGFR2, Fc-tagged Fc
Human FGFR2-621H Active Recombinant Human FGFR2 protein, His-tagged HEK293 His Met1-Glu377
Human FGFR2-5002H Recombinant Human Fibroblast Growth Factor Receptor 2 Human N/A
Human FGFR2-489H Recombinant Human Fibroblast Growth Factor Receptor 2 Mammalian cells N/A
Human FGFR2-488H Recombinant Human Fibroblast Growth Factor Receptor 2 Sf21 Insect Cell N/A
Human FGFR2-87H Recombinant Human FGFR2, His-tagged E.coli His
Human FGFR2-778H Recombinant Human FGFR2 Protein, His-tagged HEK293 His
Human FGFR2-82H Recombinant Human FGFR2, MYC/DDK-tagged HEK293 Myc/DDK
Human FGFR2-791H Recombinant Human FGFR2 Protein, DDK/His-tagged HEK293 DDK/His
Human FGFR2-595H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera E.coli Fc
Human FGFR2-28889TH Recombinant Human FGFR2 N/A
Human FGFR2-02H Recombinant Human Fibroblast Growth Factor Receptor 2, Fc-tagged Insect Cell Fc
Human FGFR2-5418H Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged Insect Cell his
Human FGFR2-428HCL Recombinant Human FGFR2 cell lysate Insect Cell N/A
Human FGFR2-2578HCL Recombinant Human FGFR2 cell lysate Human Cell N/A
Human FGFR2-779H Recombinant Human FGFR2 protein, His-tagged HEK293 His Pro 154 - Leu 358
Human FGFR2-4128H Recombinant Human FGFR2 Protein Wheat Germ N/A
Human FGFR2-705HF Recombinant Human FGFR2 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 604
Human FGFR2-2055H Recombinant Human FGFR2 Protein, DDK-tagged Insect Cell DDK
Human FGFR2-778HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 368
Human FGFR2-007H Recombinant Human FGFR2 protein, His-tagged HEK293 His It contains Pro 154 - Thr 356 (domain2-3).
Human FGFR2-621HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 367
Human FGFR2-055H Recombinant Human FGFR2 protein(IIIb), His-Avi-tagged HEK293 His-Avi It contains Arg22-Glu378.
Human FGFR2-186H Recombinant Human FGFR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGFR2-151H Recombinant Human FGFR2 Protein, His-tagged Human Cells His
Human FGFR2-705HAF647 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 604
Human FGFR2-056H Recombinant Human FGFR2 protein(IIIb), His-Avi-tagged HEK293 His-Avi It contains Arg22 - Glu289.
Human FGFR2-058H Recombinant Human FGFR2 Protein E.coli 821
Human FGFR2-008H Active Recombinant Human FGFR2 protein, His-tagged HEK293 His Pro154-Thr358
Human FGFR2-4892HF Recombinant Full Length Human FGFR2 Protein, GST-tagged In Vitro Cell Free System GST 723 amino acids
Human FGFR2-057H Recombinant Human FGFR2 protein(IIIb), hFc-tagged HEK293 hFc It contains Arg22 - Glu289.
Human FGFR2-2593H Active Recombinant Human FGFR2 protein Baculovirus-Infected Sf9 Cells N/A Pro458-Gln778
Human FGFR2-621HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 367
Human FGFR2-4117H Recombinant Human FGFR2 Protein (Met1-Glu377), C-His tagged Mammalian cells C-His Met1-Glu377
Human FGFR2-050HB Recombinant Human FGFR2 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Arg22-Glu378.
Human FGFR2-2318H Recombinant Human FGFR2 Protein (22-377), His tagged E.coli His 22-377
Human FGFR2-7303HAF488 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cells His/GST 659
Human FGFR2-4130H Recombinant Human FGFR2 Protein, GST-tagged Wheat Germ GST
Human FGFR2-7303HAF555 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cells His/GST 659
Human FGFR2-4116H Recombinant Human FGFR2 Protein (Met1-Glu378), C-His tagged Mammalian cells C-His Met1-Glu378
Human FGFR2-777HAF488 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 595
Human FGFR2-009H Active Recombinant Human FGFR2 protein, Fc-tagged HEK293 Fc Pro154-Leu358
Human FGFR2-776HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 278
Human FGFR2-705HAF488 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 604
Human FGFR2-705HAF555 Recombinant Human FGFR2 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 604
Human FGFR2-776HAF488 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 278
Human FGFR2-777HAF555 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 595
Human FGFR2-621HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 367
Human FGFR2-778HAF555 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 368
Human FGFR2-621HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 His 367
Human FGFR2-7303HAF647 Recombinant Human FGFR2 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cells His/GST 659
Human FGFR2-7303HF Recombinant Human FGFR2 Protein, His/GST-tagged, FITC conjugated Insect Cells His/GST 659
Human FGFR2-776HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 278
Human FGFR2-4891HF Recombinant Full Length Human FGFR2 Protein In Vitro Cell Free System 203 amino acids
Human FGFR2-777HAF647 Recombinant Human FGFR2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 595
Human FGFR2-186H-B Recombinant Human FGFR2 Protein Pre-coupled Magnetic Beads HEK293
Human FGFR2-778HAF647 Recombinant Human FGFR2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 368
Human FGFR2-776HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 His 278
Human FGFR2-777HF Recombinant Human FGFR2 Protein, Fc-tagged, FITC conjugated HEK293 Fc 595
Human FGFR2-778HF Recombinant Human FGFR2 Protein, His-tagged, FITC conjugated HEK293 His 368
Human FGFR2-2334HFL Recombinant Full Length Human FGFR2, Flag-tagged Mamanlian cells Flag
Human FGFR2-92H Recombinant Active Human FGFR2 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Arg22-Glu377
Human FGFR2-33H Recombinant Active Human FGFR2 (M420I) Protein (285-end), N-GST-tagged Sf9 insect cells N-GST 285-end
Human FGFR2-34H Recombinant Active Human FGFR2 (N549K) Protein (285-end), N-GST-tagged Sf9 insect cells N-GST 285-end
Human FGFR2-1230H Recombinant Human FGFR2 Protein (Arg22-Glu377), N-His tagged E.coli N-His Arg22-Glu377
Human FGFR2-2149H Active Recombinant Human FGFR2 protein, hFc-tagged HEK293 hFc Met1-Glu378
Mouse Fgfr2-427M Active Recombinant Mouse Fgfr2, Fc Chimera Mammalian cells Fc Chimera
Mouse Fgfr2-638M Active Recombinant Mouse Fgfr2 Protein, Fc Chimera Mammalian cells Fc
Mouse Fgfr2-551M Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged Mammalian cells Fc
Mouse Fgfr2-542M Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged Spodoptera Frugiperda Fc
Mouse Fgfr2-368M Active Recombinant Mouse Fgfr2, Fc Chimera Sf21 Insect Cell Fc Chimera
Mouse Fgfr2-502M Recombinant Mouse Fgfr2, His-tagged Human Cell His Met1-Glu263
Mouse Fgfr2-501M Recombinant Mouse Fgfr2, Fc-tagged Human Cell Fc Met1-Glu263
Mouse FGFR2-001MCL Recombinant Mouse FGFR2 cell lysate Human Cell N/A
Mouse Fgfr2-501MF Recombinant Mouse Fgfr2 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Glu263, 483
Mouse Fgfr2-501MAF488 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Glu263, 483
Mouse Fgfr2-501MAF555 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Glu263, 483
Mouse Fgfr2-501MAF647 Recombinant Mouse Fgfr2 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Glu263, 483
Mouse Fgfr2-3002M Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Fgfr2-502MAF488 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Glu263, 253
Mouse Fgfr2-135M-B Recombinant Mouse Fgfr2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fgfr2-502MAF555 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Glu263, 253
Mouse Fgfr2-502MF Recombinant Mouse Fgfr2 Protein, His-tagged, FITC conjugated HEK293 His Met1-Glu263, 253
Mouse Fgfr2-135M Recombinant Mouse Fgfr2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fgfr2-502MAF647 Recombinant Mouse Fgfr2 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Glu263, 253
Mouse FGFR2-1007M Active Recombinant Mouse FGFR2 protein, His-tagged HEK293 His Pro39-Leu243
Rat Fgfr2-1501R Recombinant Rat Fgfr2 Protein, His-tagged E.coli N-His Arg41-Ala285
Rhesus monkey FGFR2-1752R Recombinant Rhesus Monkey FGFR2 Protein HEK293 N/A
Rhesus monkey FGFR2-1753R Recombinant Rhesus Monkey FGFR2 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey FGFR2-1754R Recombinant Rhesus Monkey FGFR2 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus FGFR2-412C Recombinant Cynomolgus FGFR2 protein, His-tagged HEK293 His Pro154-Lys368
Cynomolgus FGFR2-1018C Recombinant Cynomolgus FGFR2 protein, His-tagged HEK293 His Pro 144 - Thr 346
Gallus gallus (Chicken) RFL5970GF Recombinant Full Length Chicken Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-823)
Homo sapiens (Human) RFL34887HF Recombinant Full Length Human Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-821)
Mus musculus (Mouse) RFL32092MF Recombinant Full Length Mouse Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-821)
Xenopus laevis (African clawed frog) RFL9320XF Recombinant Full Length Xenopus Laevis Fibroblast Growth Factor Receptor 2(Fgfr2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (15-813)
Zebrafish FGFR2-8029Z Recombinant Zebrafish FGFR2 Mammalian Cell His
Chicken FGFR2-6871C Recombinant Chicken FGFR2 Mammalian Cell His
Kit-0341 FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FGFR2 Related Articles
  • FGFR2 Related Gene Family
  • FGFR2 Related Research Area
  • FGFR2 Related Signal Pathway

FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF18A;MAP2K4A;MAPK1;IL1R1;FGF10;RAC3A;IKBKB;FGF13;CDC42L
Ras signaling pathwayRASAL3;CALM1;PAK1;RAC2;RASA4;FGF10;FGF21;MLLT4;CALM3
Rap signaling pathwayPARD6B;PDGFD;PDGFA;HGF;SIPA1L2;FLT1;PIK3R1;PLCE1;THBS1
EndocytosisRAB11BA;BF2;WASL;PIP5K1C;ITCH;EHD3;STAM2;ARR3B;KITA
PIK-Akt signaling pathwayGNG10;GNGT2;FGF3;CREB3L1;IFNAR1;IFNA13;GNB2;BAD;RHEB
Signaling pathways regulating pluripotency of stem cellsACVR1C;FZD6;IGF1;PCGF1;TCF3;NRAS;GSK3B;PIK3CD;DLX5
Regulation of actin cytoskeletonPDGFRB;ROCK2;PAK3;PIP5K1AA;MLCK2;FGF21;IQGAP2;ITGB2L;FGF10A
Pathways in cancerRASGRP3;GNG10;FZD10;LAMA3;TP53;IGF1R;GNG8;HGF;BRAF
Prostate cancerTCF7L2;BCL2;NKX3;RAF1;CREB3L2;MDM2;IKBKG;EP300;PIK3CG
Central carbon metabolism in cancerPFKL;RET;FGFR3;SIRT6;PDHA2;MAPK1;FGFR1;PDHB;NTRK3

FGFR2 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLK;SMYHC1;GLYCTK;PDPK1;RARS2;EHD3;NSFA;ABCG1;SWAP70
fibroblast growth factor bindingRPS2;GPC1;S100A13;TGFBR3;THBS1;FGFBP3;FGFR2;PTPRZ1;GLG1B
fibroblast growth factor-activated receptor activityFGFR3;FGFR1B;FGFR1A;FGFRL1;FGFR4;FGFR1;FGFR2
heparin bindingCLEC3B;OGN;CCL5;PTCH1;ZNF207;CXCL6;MSTN;VEGFA;THBS2
protein bindingADRA2C;ECE2;TACC3;MED1;HESX1;HIST3H3;CCNG1;COMMD9;FBXO44
protein homodimerization activitySMAD4;QDPR;IDH1;BHLHB9;GALE;SPPL2B;CD200;TYMS;SPATA24
protein tyrosine kinase activityTESK2;JAK3;MAP2K1;BAZ1B;ERBB2;Fert2;PTK2B;TNK1;EPHB3A

FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.

FGF1; ssr; GRB2; FGF2; FGF10

De Vita, F; Di Martino, N; et al. Clinical management of advanced gastric cancer: The role of new molecular drugs. WORLD JOURNAL OF GASTROENTEROLOGY 20:14537-14558(2014).
Zhang, Y; Pan, TC; et al. Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression. JOURNAL OF PHARMACOLOGICAL SCIENCES 126:77-83(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is FGFR2 linked to developmental disorders? 01/01/2022

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy? 04/19/2021

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors? 01/24/2020

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing? 02/28/2019

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors? 08/28/2018

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.

Customer Reviews (3)

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Reviews
08/24/2017

    The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

    03/05/2017

      What sets FGFR2 apart is the manufacturer's unparalleled technical support.

      09/13/2016

        The versatility of the FGFR2 protein makes it a valuable asset in my research.

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