fgfr2
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  • Official Full Name
  • fibroblast growth factor receptor 2
  • Background
  • The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.
  • Synonyms
  • FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621
Cat.#:FGFR2-2055HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2 Protein, DDK-tagged
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Cat.#:FGFR2-4128HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR2 Protein
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Cat.#:FGFR2-4130HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR2 Protein, GST-tagged
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Cat.#:FGFR2-5418HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, His-tagged
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Cat.#:Fgfr2-542MTag:Fc
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged
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Cat.#:Fgfr2-551MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged
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Cat.#:FGFR2-02HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, Fc-tagged
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Cat.#:FGFR2-102HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor
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Cat.#:FGFR2-18HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2 protein, GST-tagged
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Cat.#:FGFR2-28889THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR2
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Cat.#:FGFR2-31452THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FGFR2, Fc-tagged
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Cat.#:FGFR2-314HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged, Active
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Cat.#:FGFR2-481HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
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Cat.#:FGFR2-488HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
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Cat.#:FGFR2-489HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
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Cat.#:FGFR2-5002HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
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Cat.#:FGFR2-595HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera
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Cat.#:FGFR2-607HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR2, His-tagged, Biotinylated
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Cat.#:FGFR2-608HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc-tagged, Biotinylated
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Cat.#:FGFR2-621HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, His tagged
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Cat.#:FGFR2-690HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
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Cat.#:FGFR2-691HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
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Cat.#:FGFR2-705HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, Fc-His tagged
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Cat.#:FGFR2-7303HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR2, His & GST tagged
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Cat.#:FGFR2-777HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 Protein, Fc-tagged
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Cat.#:FGFR2-778HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 Protein, His-tagged
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Cat.#:FGFR2-791HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FGFR2 Protein, DDK/His-tagged
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Cat.#:FGFR2-821HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged
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Cat.#:FGFR2-82HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, MYC/DDK-tagged
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Cat.#:FGFR2-86HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged
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Cat.#:FGFR2-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR2, His-tagged
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Cat.#:Fgfr2-368MTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2, Fc Chimera
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Cat.#:Fgfr2-427MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2, Fc Chimera
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Cat.#:Fgfr2-501MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr2, Fc-tagged
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Cat.#:Fgfr2-502MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr2, His-tagged
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Cat.#:Fgfr2-638MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2 Protein, Fc Chimera
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Cat.#:FGFR2-1752RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein
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Cat.#:FGFR2-1753RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein, hIgG1-tagged
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Cat.#:FGFR2-1754RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein, hIgG4-tagged
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Cat.#:FGFR2-6871CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR2
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Cat.#:FGFR2-8029ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR2
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Cat.#:FGFR2-2578HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 cell lysate
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Cat.#:FGFR2-428HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR2 cell lysate
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Cat.#:FGFR2-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR2 cell lysate
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Cat.#:Kit-0341Tag:
Source (Host):Species:
Product nameFGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ARRB2A; NFKB1; MAP2K2A; NLK; PPP3CB; MEF2CB; MAP3K14; CACNA1DA; FGF4; PPM1B
Ras signaling pathway
PTPN11; GRB2; ARF6; BRAP; PLA2G12A; MAPK10; GAB1; ABL2; FGFR2; PRKACG
Rap signaling pathway
FGF3; ITGB3; MAPK13; INSR; NGFR; FYB; CALML5; PIK3CB; PLCB4; KRAS
Endocytosis
SH3GL3B; RHOAC; RAB11FIP4A; CXCR2; VPS28; SMAP1; TSG101A; TRAF6; NTRK1; RAB4A
PIK-Akt signaling pathway
PPP2R3A; PRKAA2; SPP1; GYS1; LPAR4; IKBKB; VTN; LAMB2; IKBKG; IFNA6
Signaling pathways regulating pluripotency of stem cells
BMPR1B; PIK3R1; BMI1; WNT8A; INHBC; WNT16; KLF4; APC; JARID2; ZIC3
Regulation of actin cytoskeleton
PAK3; PAK7; PIP5K1BB; PPP1CC; MAPK1; ACTN2; MSNA; PDGFB; IQGAP2; CDC42
Pathways in cancer
CTNNA3; PRKACG; FGF16; GNG5; TGFA; PIK3CD; LPAR2; VEGFA; CYCS; FZD3
Prostate cancer
PDPK1; FGFR1; AKT1; Ar; NDRG1; PTEN; CCND1; FOXO1; NFKBIA; TRP53
Central carbon metabolism in cancer
MTOR; PIK3CB; NRAS; AKT2; SLC16A3; HK2; SLC7A5; HRAS; PDK1; MAPK3

Protein Function

FGFR2 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PHKG2; TK2; FGR; CSNK2A2A; FARS2; ADCK3; DCKL1B; CENPE; MLH1; EIF2AK1
Function fibroblast growth factor binding
Related Protein GLG1; THBS1; FGFBP3; SCN5A; FIBPB; RPS2; S100A13; FIBP; GPC1; KLB
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR1; FGFRL1; FGFR1B; FGFR2; FGFR3; FGFR4; FGFR1A
Function heparin binding
Related Protein FGF1; FGF9; ZNF146; LIPH; IMPG2; CTGF; KAL1; VEGFAA; PTCH1; SERPINC1
Function protein binding
Related Protein GTF2F2; CENPJ; TNNI1; MZT1; ZNF747; ZNF34; INO80B; COL23A1; GALR1; TGIF1
Function protein homodimerization activity
Related Protein IKZF2; STK25; SYT16; DSCAML1; PDXK; MTPAP; NDP; SLIT2; NADK2; CIDEA
Function protein tyrosine kinase activity
Related Protein KIAA1804; IGF1R; SHC1; MATK; DSTYK; PTK7; FYN; DYRK2; SYK; ABL2

Interacting Protein

FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.
FGF1; ssr; GRB2; FGF2; FGF10

FGFR2 Related Articles

De Vita, F; Di Martino, N; et al. Clinical management of advanced gastric cancer: The role of new molecular drugs. WORLD JOURNAL OF GASTROENTEROLOGY 20:14537-14558(2014).
Zhang, Y; Pan, TC; et al. Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression. JOURNAL OF PHARMACOLOGICAL SCIENCES 126:77-83(2014).

FGFR2 Related Gene Family

Cytokines