FGFR2
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Official Full Name
fibroblast growth factor receptor 2
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Overview
The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers. -
Synonyms
FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Cynomolgus
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus monkey
- Xenopus laevis (African clawed frog)
- Zebrafish
- Baculovirus-Infected Sf9 Cells
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9 Insect Cell
- Sf9 insect cells
- Spodoptera Frugiperda
- Wheat Germ
- C
- His
- hFc
- DDK
- DDK|His
- Fc
- Fc Chimera
- His(C
- ter)
- Flag
- GST
- hIgG1
- hIgG4
- his
- His (Fc)
- Avi
- Myc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- FGFR2 Related Articles
- FGFR2 Related Gene Family
- FGFR2 Related Research Area
- FGFR2 Related Signal Pathway
FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | FGF18A;MAP2K4A;MAPK1;IL1R1;FGF10;RAC3A;IKBKB;FGF13;CDC42L |
Ras signaling pathway | RASAL3;CALM1;PAK1;RAC2;RASA4;FGF10;FGF21;MLLT4;CALM3 |
Rap signaling pathway | PARD6B;PDGFD;PDGFA;HGF;SIPA1L2;FLT1;PIK3R1;PLCE1;THBS1 |
Endocytosis | RAB11BA;BF2;WASL;PIP5K1C;ITCH;EHD3;STAM2;ARR3B;KITA |
PIK-Akt signaling pathway | GNG10;GNGT2;FGF3;CREB3L1;IFNAR1;IFNA13;GNB2;BAD;RHEB |
Signaling pathways regulating pluripotency of stem cells | ACVR1C;FZD6;IGF1;PCGF1;TCF3;NRAS;GSK3B;PIK3CD;DLX5 |
Regulation of actin cytoskeleton | PDGFRB;ROCK2;PAK3;PIP5K1AA;MLCK2;FGF21;IQGAP2;ITGB2L;FGF10A |
Pathways in cancer | RASGRP3;GNG10;FZD10;LAMA3;TP53;IGF1R;GNG8;HGF;BRAF |
Prostate cancer | TCF7L2;BCL2;NKX3;RAF1;CREB3L2;MDM2;IKBKG;EP300;PIK3CG |
Central carbon metabolism in cancer | PFKL;RET;FGFR3;SIRT6;PDHA2;MAPK1;FGFR1;PDHB;NTRK3 |
FGFR2 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | NLK;SMYHC1;GLYCTK;PDPK1;RARS2;EHD3;NSFA;ABCG1;SWAP70 |
fibroblast growth factor binding | RPS2;GPC1;S100A13;TGFBR3;THBS1;FGFBP3;FGFR2;PTPRZ1;GLG1B |
fibroblast growth factor-activated receptor activity | FGFR3;FGFR1B;FGFR1A;FGFRL1;FGFR4;FGFR1;FGFR2 |
heparin binding | CLEC3B;OGN;CCL5;PTCH1;ZNF207;CXCL6;MSTN;VEGFA;THBS2 |
protein binding | ADRA2C;ECE2;TACC3;MED1;HESX1;HIST3H3;CCNG1;COMMD9;FBXO44 |
protein homodimerization activity | SMAD4;QDPR;IDH1;BHLHB9;GALE;SPPL2B;CD200;TYMS;SPATA24 |
protein tyrosine kinase activity | TESK2;JAK3;MAP2K1;BAZ1B;ERBB2;Fert2;PTK2B;TNK1;EPHB3A |
FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.
FGF1; ssr; GRB2; FGF2; FGF10
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.
Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.
Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.
FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.
Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.
Customer Reviews (3)
Write a reviewThe FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.
What sets FGFR2 apart is the manufacturer's unparalleled technical support.
The versatility of the FGFR2 protein makes it a valuable asset in my research.
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