igf2
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  • Official Full Name
  • Insulin-like Growth Factor-II
  • Background
  • This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • IGF2; IGF-II; PP9974; C11orf43; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor type 2; GF2; FLJ22066; FLJ44734; insulin-like growth factor 2 (somatomedin A); C11orf43, chromosome 11 open reading frame 43; insulin-like growth factor II; somatomedin-A; insulin-like growth factor type 2; PP9974
Cat.#:IGF2-1220HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2 Protein (30-180 aa), GST-tagged
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Cat.#:IGF2-385HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF2 Protein, Fc-tagged
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Cat.#:IGF2-5430HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 2 (somatomedin A)
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Cat.#:IGF2-5431HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 2 (somatomedin A)
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Cat.#:IGF2-037HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human IGF2 Protein
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Cat.#:IGF2-212HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF2, StrepII-tagged
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Cat.#:IGF2-215HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human IGF2 Protein, Fc & Avi-tagged, Biotinylated
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Cat.#:IGF2-28319THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2
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Cat.#:IGF2-2HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IGF2
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Cat.#:IGF2-371HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2 insulin-like growth factor 2 (somatomedin A)
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Cat.#:IGF2-373HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Insulin-like Growth Factor 2 (Somatomedin A)
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Cat.#:IGF2-450HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 2 (Somatomedin A)
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Cat.#:IGF2-457HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 2 (Somatomedin A)
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Cat.#:IGF2-462HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2, 1-104 aa
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Cat.#:IGF2-476HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IGF2 Protein
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Cat.#:IGF2-486HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2, 25-91 aa
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Cat.#:IGF2-570HTag:His/NusA
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2, His & NusA tagged
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Cat.#:IGF2-719HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2 Protein, GST-His-tagged
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Cat.#:IGF2-816HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2 protein, His & T7-tagged
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Cat.#:IGF2-8065MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IGF2 Protein
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Cat.#:Igf2-817MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Igf2 protein, His-tagged
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Cat.#:IGF2-3005RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IGF2 Protein
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Cat.#:Igf2-818RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Igf2 protein, His-tagged
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Cat.#:IGF2-2228CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF2
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Cat.#:IGF2–323CTag:N/A
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken Insulin-Like Growth Factor 2 (Somatomedin A)
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Cat.#:IGF2-819RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IGF2 protein, His & T7-tagged
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Cat.#:igf2-447STag:N/A
Source (Host):E. coliSpecies:Salmon/Trout
Product nameRecombinant Salmo/Trout Insulin-like Growth Factor II
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Cat.#:IGF2-609HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-like Growth Factor 2 (somatomedin A)
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Cat.#:IGF2-620HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 2 (somatomedin A)
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Cat.#:IGF2-692HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin-Like Growth Factor 2 (somatomedin A)
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Cat.#:Igf2-736MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Insulin-Like Growth Factor 2
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Cat.#:IGF2-29116THTag:
Source (Host):Species:Human
Product nameNative Human IGF2
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Cat.#:IGF2-621HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human Insulin-Like Growth Factor 2 (somatomedin A)
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Cat.#:IGF2-5266HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IGF2 293 Cell Lysate
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Cat.#:IGF2-156HTag:
Source (Host):E. coliSpecies:Human
Product nameHuman Insulin-like growth Factor-II (rDNA derived) Reference standard
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Involved Pathway

IGF2 involved in several pathways and played different roles in them. We selected most pathways IGF2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteoglycans in cancer
CAMK2A; HOXD10; CAV3; AKT1; MAP2K2; WNT5A; RDX; ROCK2; TNF; PXN

Protein Function

IGF2 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2 itself. We selected most functions IGF2 had, and list some proteins which have the same functions with IGF2. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein GDF9; HDGF; TGFA; INHBAB; TIMP1; Fgf15; MSTN; PDGFD; NDR2; IL4
Function hormone activity
Related Protein INS-IGF2; PRL2C3; PTH1A; AGT; INSL5A; PRL2; NPPC; RLN2; CGA; ADM2
Function insulin receptor binding
Related Protein SHC1; PTPN11; IGF1; INS; DOK7; FRS3; ENPP1; GRB10; DOK2; DOK4
Function insulin-like growth factor receptor binding
Related Protein YWHAH; SOCS1; PIK3R1; INS2; YWHAG; REN; IGF2B; IRS1; ARRB1; GNAS
Function protein binding
Related Protein CD1B; E2F1; C1orf50; NUTF2; NRSN1; NUP37; KIAA1967; RPS25; CRBN; C7orf59
Function protein serine/threonine kinase activator activity
Related Protein STK3; ALS2; CALM3; LTF; STRADA; CDK5R1; IGF2; MAP2K2; STK4; CALM1
Function receptor activator activity
Related Protein PPARGC1B; PRKCE; IGF2

Interacting Protein

IGF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2.
IGF2R; RBPMS

IGF2 Related Articles

Plymate, SR; Bhatt, RS; et al. Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2. CANCER CELL 27:158-159(2015).
Kang, Z; Yu, Y; et al. Downregulation of IGFBP2 is associated with resistance to IGF1R therapy in rhabdomyosarcoma. ONCOGENE 33:5697-5705(2014).