| Official Full Name | Insulin-like Growth Factor-II |
| Background | This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | IGF2; IGF-II; PP9974; C11orf43; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor II; insulin-like growth factor type 2; GF2; FLJ22066; FLJ44734; insulin-like growth factor 2 (somatomedin A); C11orf43, chromosome 11 open reading frame 43; insulin-like growth factor II; somatomedin-A; insulin-like growth factor type 2; PP9974 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
IGF2 involved in several pathways and played different roles in them. We selected most pathways IGF2 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | CAMK2D; PLCG1; PIK3R2; ITGAV; FAS; WNT9A; CBL; Ctsl; FLNA; WNT7A |
IGF2 has several biochemical functions, for example, growth factor activity, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2 itself. We selected most functions IGF2 had, and list some proteins which have the same functions with IGF2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | NUDT6; IGF2; EFEMP1; INHBB; NRG2; BMP7B; CNTF; GDF6B; INHBA; NTF7 |
| hormone activity | PRLH; HAMP; TTR; FSD1; GPHB5; AMH; TSHB; PTH1B; IGF2; IGF2B |
| insulin receptor binding | PTPN1; IGF2; SHC1; INS2; SLC2A2; SNX2; LMBRD1; DOK6; INS1; FRS2A |
| insulin-like growth factor receptor binding | PIK3R1; IGF2B; YWHAG; IGF3; IGF2A; SHC1; REN; IGF2; INSL4; ARRB1 |
| protein binding | ZCCHC17; ASIC1; PMF1; RPL14; MPP7; CEP152; CCDC11; SNCG; BEX1; SULT1C2 |
| protein serine/threonine kinase activator activity | PARP16; FAM20A; CALM1; SPRY2; MAP2K2; STRADA; STK4; CALM3; LTF; IGF2 |
| receptor activator activity | PRKCE; IGF2; PPARGC1B |
IGF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2.
IGF2R; RBPMS
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