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LDLR

  • Official Full Name

    low density lipoprotein receptor

  • Overview

    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
  • Synonyms

    LDLR; FH; FHC; LDLCQ2; low density lipoprotein receptor; low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; sLOX-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Bos taurus (Bovine)
  • Chicken
  • Cynomolgus
  • Cynomolgus monkey
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human plasma
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • C
  • AVI
  • His
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • mFc
  • MYC
  • Myc|DDK
  • N/A
  • Strep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LDLR-798H Recombinant Human LDLR protein, His-tagged HEK293 His Ala22-Arg788
Human LDLR-799H Recombinant Human LDLR protein, Strep-tagged HEK293 Strep Ala22-Arg788
Human LDLR-29938TH Recombinant Human LDLR Wheat Germ N/A 101 amino acids
Human LDLR-266H Recombinant Human LDLR protein, His-tagged, Biotinylated HEK293 His Met1-Arg788
Human LDLR-241H Recombinant Human LDLR, C13&N15-labeled HEK293 N/A
Human LDLR-335H Recombinant Human LDLR protein, Fc-tagged HEK293 human/IgG1/Fc 767
Human LDLR-5715H Recombinant Human LDLR protein, His-tagged E.coli His Thr497~Thr742
Human LDLR-2780HCL Recombinant Human LDLR cell lysate Human Cell N/A
Human LDLR-0327H Active Recombinant Human LDLR protein, Fc-tagged HEK293 Fc Ala22-Arg788
Human LDLR-422H Recombinant Human LDLR Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LDLR-3666H Recombinant Human LDLR protein, GST-tagged E.coli GST 1-350 aa
Human LDLR-267H Active Recombinant Human LDLR Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human LDLR-85H Native Human Lipoprotein Human plasma N/A
Human LDLR-336H Active Recombinant Human LDLR protein, mFc-tagged HEK293 mFc Met1-Arg788
Human LDLR-1294H Active Recombinant Human LDLR protein HEK293 N/A Ala22-Arg788
Human LDLR-275H Recombinant Human LDLR Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human LDLR-0329H Active Recombinant Human LDLR protein, Fc-tagged HEK293 Fc Ala22-Arg788
Human LDLR-1286H Recombinant Human LDLR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LDLR-1033HFL Recombinant Full Length Human LDLR Protein, C-Flag-tagged Mammalian cells Flag
Human LDLR-347H Recombinant Human LDLR Protein, His-tagged HEK293 His 860
Human LDLR-344H Recombinant Human LDLR Protein, His-tagged HEK293 His 860
Human LDLR-348H Recombinant Human LDLR Protein, Fc-tagged HEK293 Fc 860
Human LDLR-346H Recombinant Human LDLR Protein, Strep-tagged HEK293 Strep 860
Human LDLR-4431H Recombinant Human LDLR Protein (Ala22-Arg788), C-AVI and His tagged Mammalian cells C-AVI and His Ala22-Arg788
Human LDLR-2674H Active Recombinant Human LDLR protein, His-tagged HEK293 His Ala22-Arg788
Human LDLR-1286H-B Recombinant Human LDLR Protein Pre-coupled Magnetic Beads HEK293
Human LDLR-4432H Recombinant Human LDLR Protein (Ala22-Arg788), C-His tagged Mammalian cells C-His Ala22-Arg788
Mouse Ldlr-646M Active Recombinant Mouse Ldlr Protein, His-tagged Mammalian cells His Ala22-Arg790
Mouse Ldlr-645M Recombinant Mouse Ldlr protein, His-tagged HEK293 His Ala22-Arg790
Mouse Ldlr-5717M Recombinant Mouse Ldlr protein, His & T7-tagged E.coli His/T7 Asp25~Gly186 (Accession # P35951)
Mouse Ldlr-5716M Recombinant Mouse Ldlr protein, His & GST-tagged E.coli His/GST Lys263~Arg509 (Accession # P35951)
Mouse Ldlr-3283M Recombinant Mouse Ldlr, His tagged Human Cell His
Mouse LDLR-2762MCL Recombinant Mouse LDLR cell lysate Human Cell N/A
Mouse Ldlr-5024M Recombinant Mouse Ldlr Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ldlr-1308M Recombinant Mouse Ldlr Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Ldlr-3283MB Recombinant Mouse Ldlr protein, His-tagged, Biotinylated HEK293 His
Mouse CAB11577RM Rabbit Anti-Mouse Low-Density Lipoprotein Receptor Monoclonal Antibody Rabbit N/A
Mouse Ldlr-349M Recombinant Mouse Ldlr Protein, His-tagged HEK293 His 862
Mouse Ldlr-5024M-B Recombinant Mouse Ldlr Protein Pre-coupled Magnetic Beads HEK293
Rat LDLR-3371R Recombinant Rat LDLR Protein Mammalian Cell His
Rat Ldlr-5718R Recombinant Rat Ldlr protein, His & T7-tagged E.coli His/T7 Ile335~Ile588 (Accession # P35952)
Rat LDLR-3027R Recombinant Rat LDLR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LDLR-3027R-B Recombinant Rat LDLR Protein Pre-coupled Magnetic Beads HEK293
Rabbit LDLR-0328R Active Recombinant Rabbit LDLR protein, Fc-tagged HEK293 Fc Ala9-Gly765
Bos taurus (Bovine) RFL14164BF Recombinant Full Length Bovine Low-Density Lipoprotein Receptor(Ldlr) Protein, His-Tagged E.coli expression system His Full Length (1-264)
Cynomolgus LDLR-366C Recombinant Cynomolgus LDLR protein, His-tagged HEK293 His 767
Cynomolgus monkey LDLR-345C Recombinant Cynomolgus monkey LDLR Protein, His-tagged HEK293 His 860
Rhesus Macaque LDLR-2489R Recombinant Rhesus monkey LDLR Protein, His-tagged Mammalian Cell His
Rhesus Macaque LDLR-2310R Recombinant Rhesus Macaque LDLR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LDLR-2310R-B Recombinant Rhesus Macaque LDLR Protein Pre-coupled Magnetic Beads HEK293
Chicken LDLR-6022C Recombinant Chicken LDLR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LDLR Related Articles
  • LDLR Related Research Area

LDLR involved in several pathways and played different roles in them. We selected most pathways LDLR participated on our site, such as Endocytosis, Ovarian steroidogenesis, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDLR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
EndocytosisASAP1;ARAP2;GRK4;ERBB3;ARPC5L;HSC70;VTA1;RAB5B;PARD3
Ovarian steroidogenesisBMP15;INS2;PLA2G4A;INS1;SCARB1;CYP2J6;IGF1R;PTGS2;BMP6
Aldosterone synthesis and secretionSTAR;NETO2;CREB3L1;KCNK3;SCARB1;ATF1;CAMK2B;AGTR1;PRKCG
Bile secretionAQP8;NR1H4;LDLR;ADCY7;Car2;ATP1A3;SLC5A1;ABCB4;PRKACA
ToxoplasmosisIL12A;CASP9;TLR4;STAT1;HLA-DPA1;Toxoplasma Gondii Dense Granule Protein 7;HSPA1L;LAMC2;HLA-DRB5
Hepatitis CPIK3CA;CLDN18;CLDN16;CLDN23;RELA;SOS1;IFNA10;CLDN22;TP53

LDLR has several biochemical functions, for example, calcium ion binding, clathrin heavy chain binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDLR itself. We selected most functions LDLR had, and list some proteins which have the same functions with LDLR. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCDH10;MASP1;RGN;CD97;NOTCH3;CABP1;MYL2;HSPA5;PKD2L2
clathrin heavy chain bindingCLTA;CLTB;GPR107;KIAA1199;LDLR;PICALM
glycoprotein bindingCDH1;AZGP1;ERBB2;RAB14;LDLR;RASA1;HSPA5;LGALS1;SERPINA1
low-density lipoprotein particle bindingTHBS1;LIPC;ANKRA2;SCARB1;SCARF1;SORL1;COLEC12;CDH13;PCSK9
low-density lipoprotein receptor activityVLDLR;CXCL16;LRP12;LRP6;OLR1;LDLR
protease bindingADAMTSL4;C10orf2;BDKRB2;INSL3;F3;XBP1;Serpina1c;SERPINA1D;CHL1
protein bindingGPC3;ZNF576;MAF;GPN3;RPL39L;PTGES3;TUFT1;FKBP8;FARSA
receptor activityCSF2RA;MED24;PVRL2L;UBXN6;MED16;TNFRSF6B;GRIN2BB;CD160;V1RA8
very-low-density lipoprotein particle receptor activityVLDLR;LDLR;APOBR
virus receptor activityITGA5;TNFRSF14;DPP4;HAVCR1;ITGB6;RPSA;SCARB2;TNFRSF4;SIVA1

LDLR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDLR here. Most of them are supplied by our site. Hope this information will be useful for your research of LDLR.

PCSK9; APOE; APOB; env; FLT1

Wang, X; Berry, E; et al. MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells. FEBS LETTERS 589:490-496(2015).
Tavori, H; Rashid, S; et al. On the function and homeostasis of PCSK9: Reciprocal interaction with LDLR and additional lipid effects. ATHEROSCLEROSIS 238:264-270(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there conditions where upregulation of LDLR might be beneficial? 03/17/2022

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications? 09/02/2021

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction? 09/01/2020

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis? 05/27/2020

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions? 02/23/2018

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.

Customer Reviews (3)

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Reviews
08/11/2020

    The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    10/07/2018

      Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

      03/04/2017

        the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

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