lgals3
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  • Official Full Name
  • lectin, galactoside-binding, soluble, 3
  • Background
  • This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants
  • Synonyms
  • L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS3; Galactose specific lectin 3; L34; L-31; L-34; Laminin binding protein; Lectin L 29; MGC105387; Galectin-3; LGALS3; CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2; 35 kDa lectin; IgE-binding protein; MAC-2 antigen; carbohydrate-binding protein 35; galactose-specific lectin 3; laminin-binding protein; lectin L-29
Cat.#:LGALS3-276HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LGALS3 Protein, His-tagged
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Cat.#:LGALS3-3622HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3
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Cat.#:LGALS3-12HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LGALS3, MYC/DDK-tagged
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Cat.#:LGALS3-222HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3, His-tagged
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Cat.#:LGALS3-3623HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human LGALS3, His-tagged
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Cat.#:LGALS3-408HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3 Protein, His-tagged
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Cat.#:LGALS3-453HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3 protein, GST-tagged
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Cat.#:LGALS3-4952HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3 protein
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Cat.#:LGALS3-6914HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Lectin, Galactoside-Binding, Soluble, 3, His-tagged
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Cat.#:LGALS3-6977HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LGALS3, None tagged
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Cat.#:Lgals3-190MTag:His
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Lgals3 protein, His-tagged
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Cat.#:LGALS3-367MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse lectin, galactoside-binding, soluble, 3, His-tagged
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Cat.#:Lgals3-409MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lgals3 Protein, His-tagged
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Cat.#:Lgals3-5677MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lectin, Galactose Binding, Soluble 3
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Cat.#:Lgals3-647MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lgals3
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Cat.#:LGALS3-3387RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LGALS3 Protein
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Cat.#:Lgals3-343RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lgals3 protein, His-tagged
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Cat.#:Lgals3-410RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lgals3 Protein, His-tagged
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Cat.#:LGALS3-2501RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LGALS3 Protein, His-tagged
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Cat.#:LGALS3-411RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit LGALS3 Protein, His/GST-tagged
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Cat.#:LGALS3-7142CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LGALS3
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Cat.#:LGALS3-452HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Lectin, Galactoside-Binding, Soluble, 3
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Cat.#:LGALS3-4766HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LGALS3 293 Cell Lysate
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Involved Pathway

LGALS3 involved in several pathways and played different roles in them. We selected most pathways LGALS3 participated on our site, such as AGE/RAGE pathway, Advanced glycosylation endproduct receptor signaling, Hedgehog signaling events mediated by Gli proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGALS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
JUN; CHUK; DDOST; LGALS3; JAK2; AGER; TIRAP; DIAPH1; ATF2; MMP13
Advanced glycosylation endproduct receptor signaling
APPB; ALCAMB; S100A12; AGER; DDOST; LGALS3; S100B; APPA; SAA1
Hedgehog signaling events mediated by Gli proteins
SAP18; SIN3B; KIF3A; SPOP; SAP30; CSNK1G2; IFT88; LGALS3; MTSS1; CSNK1G3
Immune System
BAIAP2; KIF15; DDOST; UBE2U; IRAK3; ASB13; SPSB2; ABI2; CRP; LRSAM1
Innate Immune System
CFHL3; BTR30; SIGIRR; RCA2.1; SUGT1; DEFB119; ART1; BTR02; IRF2; KIR3DS1
Spinal Cord Injury
GDNF; RGMA; LILRB3; OMG; RTN4R; TNFSF13B; PTPRZ1; MBP; LGALS3; NOX4

Protein Function

LGALS3 has several biochemical functions, for example, IgE binding, carbohydrate binding, chemoattractant activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGALS3 itself. We selected most functions LGALS3 had, and list some proteins which have the same functions with LGALS3. You can find most of the proteins on our site.
Function
Related Protein
Function IgE binding
Related Protein LGALS3; FCER1A; Fcer2a; FCER2; CD247L; MS4A2; FCER1G
Function carbohydrate binding
Related Protein LGALS2A; FBXO2; EVA1C; ASGR1; GFPT2; KLRB1A; GALNT7; PYGM; CLEC3A; KLRC4-KLRK1
Function chemoattractant activity
Related Protein FGF2; VEGFC; CCL15; MIF; BMP4; FGF10; CCL5; SAA2; HGF; FGF8
Function laminin binding
Related Protein ITGA7; LGALS1; RPSA; LYPD3; GPC1; LGALS2A; ECM1; TINAGL1; NCL; AGRN
Function poly(A) RNA binding
Related Protein RPS9; TPT1; FNDC3A; ANXA11; FTSJ3; EIF3A; HADHB; NUFIP2; SYF2; MTDH
Function protein binding
Related Protein AP2B1; C9orf100; SDCBP2; PTGER4; DBNDD2; MYOZ2; DDIT4L; MYL7; RBM17; CALCOCO2

Interacting Protein

LGALS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGALS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGALS3.
SS18L1; CD6; GOLGA2; PPIG; ALCAM; PRR13; AHSG; MICA

LGALS3 Related Articles

Nio-Kobayashi, J; Boswell, L; et al. The Loss of Luteal Progesterone Production in Women Is Associated With a Galectin Switch via alpha 2,6-Sialylation of Glycoconjugates. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:4616-4624(2014).
Ma, J; Yao, YL; et al. MiR-152 functions as a tumor suppressor in glioblastoma stem cells by targeting Kruppel-like factor 4. CANCER LETTERS 355:85-95(2014).