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  • Official Full Name
  • leukemia inhibitory factor
  • Background
  • LIF (Leukocyte inhibitory factor) is produced by various fibroblast cell lines, antigen-stimulated alloreactive T-lymphocytes, mitogen-activated spleen cells, and Krebs and Ehrlich ascites cells. It is also produced by monocytes after cell activation. This factor inhibits the random and directed migration of polymorphonuclear (PMN) leukocytes. LIF also induces specific granule secretion by PMNs and potentiates many responses mediated by the chemotactic compound fMLP (formyl-methionyl-leucyl-phenylalanine). It activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes.
  • Synonyms
  • LIF; leukemia inhibitory factor; CDF; cholinergic differentiation factor; DIA; differentiation inhibitory activity; differentiation inducing factor; hepatocyte stimulating factor III; HILDA; human interleukin in DA cells; D factor; melanoma-derived LPL inhibitor; differentiation-inducing factor; hepatocyte-stimulating factor III; differentiation-stimulating factor; MLPLI
Cat.#:LIF-2031HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF Protein, His-tagged
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Cat.#:LIF-420HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF Protein, His-Avi-tagged, Biotinylated
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Cat.#:LIF-527HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF Protein, MYC/DDK-tagged
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Cat.#:LIF-4404CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken LIF Protein
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Cat.#:LIF-378HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human leukemia Inhibitory Factor
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Cat.#:Lif-379RTag:GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Leukemia Inhibitory Factor, GST-tagged
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Cat.#:LIF-134HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LIF protein, His-tagged
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Cat.#:LIF-167HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIF Protein, Biotinylated
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Cat.#:LIF-217HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF, StrepII-tagged
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Cat.#:LIF-22HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Leukemia Inhibitory Factor
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Cat.#:LIF-328HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF
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Cat.#:LIF-406HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF, Fc tagged
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Cat.#:LIF-419HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF, His tagged
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Cat.#:LIF-514HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIF
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Cat.#:LIF-634HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human LIF, His-tagged, Biotinylated
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Cat.#:LIF-635HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human LIF, Fc-tagged, Biotinylated
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Cat.#:LIF-8868HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human LIF, His-tagged
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Cat.#:Lif-10MTag:N/A
Source (Host):Hordeum vulgareSpecies:Mouse
Product nameRecombinant mouse LIF
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Cat.#:Lif-23MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Leukemia Inhibitory Factor
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Cat.#:Lif-31MTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Mouse
Product nameRecombinant Mouse Lif, His-tagged
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Cat.#:Lif-521MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lif
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Cat.#:Lif-556MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lif
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Cat.#:Lif-679MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lif protein, His-tagged
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Cat.#:Lif-719MTag:His
Source (Host):Human cellsSpecies:Mouse
Product nameRecombinant Mouse Lif, His-tagged, Biotinylated
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Cat.#:Lif-720MTag:Fc
Source (Host):Human cellsSpecies:Mouse
Product nameRecombinant Mouse Lif, Fc-tagged, Biotinylated
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Cat.#:Lif-756MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lif, Fc tagged
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Cat.#:Lif-757MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lif, His tagged
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Cat.#:Lif-8869MTag:
Source (Host):Hordeum vulgareSpecies:Mouse
Product nameRecombinant Mouse LIF,His-tagged
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Cat.#:LIF-677DTag:His/T7
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog LIF protein, His & T7-tagged
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Cat.#:LIF-472HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIF, His-GST
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Cat.#:LIF-1071HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIF cell lysate
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Cat.#:LIF-1729MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LIF cell lysate
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Cat.#:LIF-4343HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human LIF protein
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Cat.#:LIF-129HTag:
Source (Host):Species:Human
Product nameHuman Leukaemia Inhibitory Factor(rDNA derived) Reference standard
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Involved Pathway

LIF involved in several pathways and played different roles in them. We selected most pathways LIF participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF25; CXCR5; CNTF; CCL5; IFNA12; CXCL6; KIT; IL4; TSLP; TNFRSF4
Signaling pathways regulating pluripotency of stem cells
BMPR1B; FZD8; LIF; HNF1A; FZD9; KLF4; ID4; RAF1; GSK3B; Fzd4
Jak-STAT signaling pathway
IL12B; IFNAR2; IFNGR1; SOCS3; IFNA3; IFNA8; CNTFR; LEP; SOCS9; PIAS1
TNF signaling pathway
PIK3CA; TRAF3; IL18R1; CCL2; MAPK11; RELA; SELE; VEGFC; MAPK3; IL1B

Protein Function

LIF has several biochemical functions, for example, cytokine activity, growth factor activity, leukemia inhibitory factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIF itself. We selected most functions LIF had, and list some proteins which have the same functions with LIF. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein CSF2; GPI; TNFSF9; IL33; IL36A; BMP15; GDF6B; FAM3D; GDF7; IL17A/F3
Function growth factor activity
Related Protein IL4; FGF18B; BMP1; MDKA; TGFB1; HDGF; NTF7; FGF13; FGF9; ANGPTL3
Function leukemia inhibitory factor receptor binding
Related Protein LIF; CTF1; Ctf2
Function receptor binding
Related Protein LTB; TNFSF13; JAK2; TIGIT; FGF20A; ABCA1; LYN; FRK; SCYL2; CADM2A
Function transcription factor activity, RNA polymerase II transcription factor recruiting
Related Protein LIF; NCOA3

Interacting Protein

LIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIF here. Most of them are supplied by our site. Hope this information will be useful for your research of LIF.
IL6ST; LIFR

LIF Related Articles

Levy, YA; Mausner-Fainberg, K; et al. Dysregulated production of leukemia inhibitory factor in immune cells of relapsing remitting multiple sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY 278:85-89(2015).
Leung, SJ; Rice, PS; et al. In Vivo Molecular Mapping of the Tumor Microenvironment in an Azoxymethane-Treated Mouse Model of Colon Carcinogenesis. LASERS IN SURGERY AND MEDICINE 47:40-49(2015).

LIF Related Gene Family

IL