mica
Share
  • Official Full Name
  • MHC class I polypeptide-related sequence A
  • Background
  • MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, ??T cells and CD8+??T cells. Recognition of MICA and MICB by
  • Synonyms
  • MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087
Cat.#:MICA-5319HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MICA Protein, GST-tagged
+Inquiry
Cat.#:MICA-1232HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA Protein, Fc-tagged
+Inquiry
Cat.#:MICA-1235HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA Protein, MYC/DDK-tagged
+Inquiry
Cat.#:MICA-1280HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MICA Protein, His-tagged
+Inquiry
Cat.#:MICA-30099THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MICA
+Inquiry
Cat.#:MICA-3970HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA, His tagged
+Inquiry
Cat.#:MICA-705HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MICA, Fc Chimera
+Inquiry
Cat.#:MICA-07HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MHC class I polypeptide-related sequence A
+Inquiry
Cat.#:MICA-1941HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA cell lysate
+Inquiry

Involved Pathway

MICA involved in several pathways and played different roles in them. We selected most pathways MICA participated on our site, such as Adaptive Immune System, Allograft Rejection, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MICA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
AKR1C1; NRG3; ASB3; FBXO3; PAG1; ITK; CYBB; SLAMF6; PTBP3; RASGRP2
Allograft Rejection
FAS; HLA-DMA; H2-AB1; HLA-DMB; FASLG; HLA-DRB5; HLA-DRB3; HLA-DQA2; H2-AA; Fasl
Immune System
DEFB103A; TREML4; CRP; LILRA2; KIFAP3; PIK3AP1; ERAP1; CTSH; FCN3; NCKIPSD
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
KIR2DS2; MICA; KLRB1A; CD200R3; CD300C; KLRF1; CD300LG; CD226; SH2D1B; CD200R1
Natural killer cell mediated cytotoxicity
LCP2; FCGR3B; LAT; IFNA8; MAP2K1; Ifna11; CD247; HRAS; VAV3; RAF1

Protein Function

MICA has several biochemical functions, for example, NOT beta-2-microglobulin binding, natural killer cell lectin-like receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICA itself. We selected most functions MICA had, and list some proteins which have the same functions with MICA. You can find most of the proteins on our site.
Function
Related Protein
Function NOT beta-2-microglobulin binding
Related Protein MICA
Function natural killer cell lectin-like receptor binding
Related Protein ULBP1; HLA-E; RAET1L; ULBP2; MICB; RAET1D; ULBP3; CLEC2G; Mill2; RAET1E
Function protein binding
Related Protein RAB25; IRF4; CDON; CCBE1; ZRSR2; HOXC4; GNS; ATG7; BRCC3; TBC1D2

Interacting Protein

MICA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICA here. Most of them are supplied by our site. Hope this information will be useful for your research of MICA.
KLRK1; LGALS3; POT1

MICA Related Articles

Fujita, H; Hatanaka, Y; et al. Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 63:217-227(2015).
Flaxa, J; Rosner, A; et al. Methodological and clinical aspects of alloimmunization after granulocyte transfusion in patients undergoing allogeneic stem cell transplantation. TISSUE ANTIGENS 85:93-103(2015).