mica
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  • Official Full Name
  • MHC class I polypeptide-related sequence A
  • Background
  • MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, ??T cells and CD8+??T cells. Recognition of MICA and MICB by
  • Synonyms
  • MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087
Cat.#:MICA-1232HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA Protein, Fc-tagged
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Cat.#:MICA-1235HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA Protein, MYC/DDK-tagged
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Cat.#:MICA-1280HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MICA Protein, His-tagged
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Cat.#:MICA-5319HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MICA Protein, GST-tagged
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Cat.#:MICA-30099THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MICA
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Cat.#:MICA-3970HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA, His tagged
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Cat.#:MICA-705HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MICA, Fc Chimera
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Cat.#:MICA-07HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MHC class I polypeptide-related sequence A
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Cat.#:MICA-1941HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MICA cell lysate
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Involved Pathway

MICA involved in several pathways and played different roles in them. We selected most pathways MICA participated on our site, such as Adaptive Immune System, Allograft Rejection, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MICA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
ASB2; KIFAP3; CREB1; CLEC2B; IGHM; KLB; LILRA1; AMICA1; DYNC1LI2; NCR3LG1
Allograft Rejection
TNF; IL12A; HLA-DQB1; HLA-DQA2; IL12B; H2-Q10; HLA-DRB5; HLA-DRA; HLA-E; HLA-DRB4
Immune System
MX2; TIRAP; KIF3C; HERC5; EIF4G2; IFIT12; CLEC4D; CD300LD; IFI16; TAX1BP1
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
KLRF1; LILRB2; SIGLEC11; SIGLEC10; SLAMF6; CD300LB; CD300LG; SIGLEC8; PVRL2L; CD300A
Natural killer cell mediated cytotoxicity
TNFSF10; LAT; KIR2DL3; NRAS; Raet1c; PIK3CG; RAET1L; TNFRSF10A; HCST; IFNA10

Protein Function

MICA has several biochemical functions, for example, NOT beta-2-microglobulin binding, natural killer cell lectin-like receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICA itself. We selected most functions MICA had, and list some proteins which have the same functions with MICA. You can find most of the proteins on our site.
Function
Related Protein
Function NOT beta-2-microglobulin binding
Related Protein MICA
Function natural killer cell lectin-like receptor binding
Related Protein RAET1E; RAET1D; ULBP2; CLEC2H; Raet1a; MICB; H60a; ULBP1; ULBP3; MICA
Function protein binding
Related Protein LYAR; ZMAT4; SLC25A23; KIF27; IRF5; MCM7; PDXP; DROSHA; TMED10; RAB1

Interacting Protein

MICA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICA here. Most of them are supplied by our site. Hope this information will be useful for your research of MICA.
KLRK1; LGALS3; POT1

MICA Related Articles

Fujita, H; Hatanaka, Y; et al. Immunohistochemical Validation and Expression Profiling of NKG2D Ligands in a Wide Spectrum of Human Epithelial Neoplasms. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 63:217-227(2015).
Flaxa, J; Rosner, A; et al. Methodological and clinical aspects of alloimmunization after granulocyte transfusion in patients undergoing allogeneic stem cell transplantation. TISSUE ANTIGENS 85:93-103(2015).