MIF
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Official Full Name
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
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Overview
MIF is a proinflammatory cytokine involved in many inflammatory reactions and disorders. MIF (macrophage migration inhibitory factor) was one of the first cytokines to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity. MIF is involved in both autoimmune disorders and tumorigenesis. -
Synonyms
MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor); GIF; GLIF; MMIF; Macrophage migration inhibitory factor; EC=5.3.2.1; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; EC=5.3.3.12; Phenylpyruvate tautomerase; OTTHUMP00000198465;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- GMP Proteins
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- E.coll
- HEK293
- HEK293T
- Hi-5 Insect Cell
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- Met
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MIF Related Articles
- MIF Related Research Area
MIF involved in several pathways and played different roles in them. We selected most pathways MIF participated on our site, such as Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | HPDA;TYRP1;PNMT;GOT1;DCT;ADH2-1;AOX3L1;AOX3;GSTZ1 |
| Phenylalanine metabolism | GM4952;GOT2A;HPD;TAT;IL4I1;GOT2;GOT2B;MAOB;PAH |
MIF has several biochemical functions, for example, chemoattractant activity, cytokine activity, cytokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MIF itself. We selected most functions MIF had, and list some proteins which have the same functions with MIF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemoattractant activity | SAA2;SAA3;CCL16;CCL15;CXCL12;FGF7;SAA4;PDGFB;HMGB1 |
| cytokine activity | IFNA1;BMP5;LIF;RNF207B;LEFTY2;FAM3B;CCL4;IL8L2;IL36RN |
| cytokine receptor binding | IL17B;IFNW1;IL15L;IFN-a;IFNA5;IL17A/F3;IL15;IL17A;IFNA12 |
| dopachrome isomerase activity | MIF;DDT;DCT |
| phenylpyruvate tautomerase activity | |
| protein binding | RHOJ;TPD52;BCL2L13;ESYT2;C4orf19;RBFOX2;ALDOB;CLIC2;ATP1B1 |
| receptor binding | AGXT;Ar;AGRP2;PTK6B;IL29;FGF18B;MTSS1;MCHR1;DAO |
MIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MIF here. Most of them are supplied by our site. Hope this information will be useful for your research of MIF.
COPS5; BCL2L11; CFLAR; FIBP; BCL2L11; BCL2L11; EIF1B; EPB41; MPG; HLA-B; VHL; ILK; IKBKE; DSTYK
- Q&As
- Reviews
Q&As (5)
Ask a questionMIF can promote inflammation and immune responses, contributing to autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.
MIF is involved in the regulation of neuroinflammation and has implications in neurodegenerative diseases like Alzheimer's.
MIF is implicated in conditions like autoimmune diseases, sepsis, and cancer.
Yes, targeting MIF with drugs or antibodies is being explored as a potential treatment for autoimmune diseases.
MIF is also studied in the context of cardiovascular diseases, neuroinflammation, and wound healing.
Customer Reviews (3)
Write a reviewThe cost-effectiveness of the MIF protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.
the manufacturer's commitment to delivering the MIF protein in a timely manner is greatly appreciated.
the excellent technical support provided by the manufacturer is of immense value to me.
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