mif
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  • Official Full Name
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor)
  • Background
  • MIF is a proinflammatory cytokine involved in many inflammatory reactions and disorders. MIF (macrophage migration inhibitory factor) was one of the first cytokines to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity. MIF is involved in both autoimmune disorders and tumorigenesis.
  • Synonyms
  • MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor); GIF; GLIF; MMIF; Macrophage migration inhibitory factor; EC=5.3.2.1; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; EC=5.3.3.12; Phenylpyruvate tautomerase; OTTHUMP00000198465
Cat.#:MIF-1355HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MIF Protein, MYC/DDK-tagged
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Cat.#:MIF-1358HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF Protein
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Cat.#:MIF-5336HTag:
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MIF Protein
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Cat.#:MIF-5337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MIF Protein, GST-tagged
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Cat.#:MIF-1359MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse MIF Protein, His-tagged
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Cat.#:MIF-09HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF
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Cat.#:MIF-162HTag:Met
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, Met-tagged
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Cat.#:MIF-198HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF protein
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Cat.#:MIF-23HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, His-tagged C-Terminus
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Cat.#:MIF-24HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, His-tagged N-Terminus
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Cat.#:MIF-277HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MIF
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Cat.#:MIF-30234THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, His-tagged
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Cat.#:MIF-3816HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MIF, His tagged
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Cat.#:MIF-4742HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Macrophage Migration Inhibitory Factor
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Cat.#:MIF-650HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, His-tagged
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Cat.#:MIF-736HTag:His
Source (Host):Hi-5 Insect cellsSpecies:Human
Product nameRecombinant Human MIF Protein, His-tagged
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Cat.#:MIF-81HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MIF, His-tagged
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Cat.#:Mif-4001MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mif, His tagged
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Cat.#:Mif-5189MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mif, None tagged
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Cat.#:Mif-648MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mif
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Cat.#:Mif-675MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mif protein, His-tagged
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Cat.#:Mif-71MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mif, His-tagged
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Cat.#:MIF-3683RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MIF Protein
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Cat.#:Mif-676RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mif protein, His-tagged
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Cat.#:MIF-694CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MIF Protein, His-tagged
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Cat.#:MIF-2772RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MIF Protein, His-tagged
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Cat.#:MIF-3847ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MIF
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Cat.#:MIF-1917HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MIF cell lysate
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Cat.#:MIF-1884MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MIF cell lysate
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Involved Pathway

MIF involved in several pathways and played different roles in them. We selected most pathways MIF participated on our site, such as Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MIF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tyrosine metabolism
IL4I1; AOX4; MAOA; MAOB; HPDA; FAHD1; GSTZ1; ALDH3A1; DBH; HPDB
Phenylalanine metabolism
ALDH1A3; KEG1; HPDB; TAT; MAOB; AOC3; AOC2; IL4I1; ALDH3A1; GOT2

Protein Function

MIF has several biochemical functions, for example, chemoattractant activity, cytokine activity, cytokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MIF itself. We selected most functions MIF had, and list some proteins which have the same functions with MIF. You can find most of the proteins on our site.
Function
Related Protein
Function chemoattractant activity
Related Protein CCL3; FGF10; HMGB1; VEGFC; FIGF; CXCL12A; CCL15; SAA4; SCG2; FGF8
Function cytokine activity
Related Protein GDF10B; TNF; CMTM5; BMP8A; IFNA6; FLT3LG; IL4; IFNA5; IFNPHI3; GPI1
Function cytokine receptor binding
Related Protein IL17A/F2; IFNA12; IFNA14; IFNA21; Ifna11; IFNA8; IL17A/F3; IFNW1; IL15; IL17F
Function dopachrome isomerase activity
Related Protein DCT; MIF; DDT
Function phenylpyruvate tautomerase activity
Related Protein MIF
Function protein binding
Related Protein PYYA; YARS2; HMGA2; TUBA1C; SEMA3E; KLF11; ZC3HAV1; WFDC9; CPSF2; SMARCAL1
Function receptor binding
Related Protein MPV17L; HSPA1B; VTCN1; POMC; CADM3; DECR2; HAMP; ADM; GIPC1; CD200

Interacting Protein

MIF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MIF here. Most of them are supplied by our site. Hope this information will be useful for your research of MIF.
COPS5; BCL2L11; CFLAR; FIBP; BCL2L11; BCL2L11; EIF1B; EPB41; MPG; HLA-B; VHL; ILK; IKBKE; DSTYK

MIF Related Articles

Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
Zis, O; Zhang, S; et al. Hypoxia Signaling Regulates Macrophage Migration Inhibitory Factor (MIF) Expression in Stroke. MOLECULAR NEUROBIOLOGY 51:155-167(2015).