mstn
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  • Official Full Name
  • myostatin
  • Background
  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth.
  • Synonyms
  • MSTN; myostatin; GDF8; Growth/differentiation factor 8; GDF-8; OTTHUMP00000163498; growth differentiation factor 8
Cat.#:MSTN-2089HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSTN Protein, MYC/DDK-tagged
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Cat.#:MSTN-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myostatin
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Cat.#:Mstn-355MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Myostatin
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Cat.#:MSTN-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSTN protein
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Cat.#:MSTN-119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSTN, His-tagged
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Cat.#:MSTN-120HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human myostatin Propepetide
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Cat.#:MSTN-121HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MSTN, GST-tagged
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Cat.#:MSTN-122HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MSTN, GST-tagged
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Cat.#:MSTN-124HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSTN
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Cat.#:MSTN-125HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSTN
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Cat.#:MSTN-136HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human MSTN, His-tagged
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Cat.#:MSTN-137HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human MSTN Active, His-tagged
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Cat.#:MSTN-1563HTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant human MSTN, Active, His-tagged
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Cat.#:MSTN-15HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MSTN protein
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Cat.#:MSTN-462HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human MSTN protein, His-tagged
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Cat.#:Mstn-911HTag:N/A
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human Mstn
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Cat.#:Mstn-1753MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mstn protein, His-tagged
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Cat.#:Mstn-490MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mstn, Fc tagged
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Cat.#:Mstn-649MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Mstn Protein, Fc Chimera
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Cat.#:Mstn-910MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Mstn Protein, His-tagged
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Cat.#:Mstn-912MTag:N/A
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Mstn
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Cat.#:Mstn-1754RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mstn protein, His-tagged
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Cat.#:MSTN-3798RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MSTN Protein
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Cat.#:Mstn-913RTag:N/A
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Mstn
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Cat.#:MSTN-711CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MSTN Protein, His-tagged
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Cat.#:MSTN-2880RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MSTN Protein, His-tagged
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Cat.#:MSTN-1104CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MSTN
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Cat.#:MSTN-1752CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle MSTN protein, His-tagged
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Cat.#:MSTN-1754PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig MSTN protein, His-tagged
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Cat.#:MSTN-507HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSTN, His-tagged
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Cat.#:MSTN-2229MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MSTN cell lysate
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Cat.#:Mstn-121HGTag:N/A
Source (Host):NS0Species:Human
Product nameGMP Recombinant Human MSTN Protein
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Involved Pathway

Mstn involved in several pathways and played different roles in them. We selected most pathways Mstn participated on our site, such as Hypertrophy Model, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mstn were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hypertrophy Model
IFRD1; HBEGFB; JUND; ZEB1B; CYR61; ANKRD1; WDR1; MSTNB; DUSP14; MSTN

Protein Function

Mstn has several biochemical functions, for example, cytokine activity, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mstn itself. We selected most functions Mstn had, and list some proteins which have the same functions with Mstn. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein IL17A; CD40LG; IFNG1-1; HMGB1B; IL31; GDF9; CCL20A.3; IL6; Gm13290; FAM3D
Function growth factor activity
Related Protein FGF18A; EGF; FGF12A; CLCF1; FGF18; FGF12B; OSM; IGF2B; FGF10; FGF13A
Function heparin binding
Related Protein SLIT2; C6orf25; MDK; WISP3; RSPO2; FSTL1; CXCL13; RSPO1; CCDC80; GM4980
Function identical protein binding
Related Protein PYDC3; MVK; BLOC1S6; NOL3; CCDC109A; IL12B; TLE1; CBY1; RIPK3; STK10
Function protein binding
Related Protein KIAA0101; SH3GLB1; RARS; ZFYVE28; ESR2; RPL14; CNST; TCEB1; GATA5; PRPS2
Function receptor binding
Related Protein ACOX2; NRG4; HRG; SCP2; HLA-B; SLC39A1; FZD1; CADM2; MSN; MAP7
Function transforming growth factor beta receptor binding
Related Protein SPAW; INHBAA; INHBA; USP15; GDF5; TGFB2; FKBP1A; BMP7; LFT1; TGFBRAP1

Interacting Protein

Mstn has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mstn here. Most of them are supplied by our site. Hope this information will be useful for your research of Mstn.
FURIN; BMP1; WFIKKN1; ACVR2B

Mstn Related Articles

Tang, L; Liu, CT; et al. A prepared anti-MSTN polyclonal antibody reverses insulin resistance of diet-induced obese rats via regulation of PI3K/Akt/mTOR&FoxO1 signal pathways. BIOTECHNOLOGY LETTERS 36:2417-2423(2014).
Bialek, P; Parkington, J; et al. A myostatin and activin decoy receptor enhances bone formation in mice. BONE 60:162-171(2014).