nrg1
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  • Official Full Name
  • neuregulin 1
  • Background
  • The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). [provided by RefSeq, May 2009]
  • Synonyms
  • NRG1; neuregulin 1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; pro-neuregulin-1, membrane-bound isoform; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; neuregulin 1 type IV beta 3; neuregulin 1 type IV beta 1a; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator);
Cat.#:NRG1-23MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Nrg1 Protein, His-tagged
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Cat.#:NRG1-029HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Neuregulin 1
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Cat.#:NRG1-2675HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Neuregulin 1
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Cat.#:NRG1-06HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1 protein
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Cat.#:NRG1-10HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1, Fc tagged
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Cat.#:NRG1-16HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1
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Cat.#:NRG1-183HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1
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Cat.#:NRG1-239HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 Protein, Fc-tagged
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Cat.#:NRG1-240HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 Protein, His-tagged
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Cat.#:NRG1-27577THTag:His
Source (Host):Species:Human
Product nameRecombinant Human NRG1, His-tagged
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Cat.#:NRG1-325HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 Protein, Fc-tagged
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Cat.#:NRG1-678HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1
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Cat.#:NRG1-679HTag:His
Source (Host):Baculovirus Sf21 Insect CellsSpecies:Human
Product nameRecombinant Human NRG1 Protein, His-tagged
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Cat.#:NRG1-709HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1 Protein, His-tagged
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Cat.#:NRG1-710HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NRG1 Protein, His-tagged
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Cat.#:NRG1-7320HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1, Fc tagged
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Cat.#:NRG1-7321HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1, None tagged
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Cat.#:Nrg1-1755MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nrg1 protein, His & GST-tagged
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Cat.#:Nrg1-1892RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nrg1 protein, His-tagged
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Cat.#:NRG1-1049CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1 Protein, His-tagged
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Cat.#:NRG1-1050CTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1 Protein
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Cat.#:NRG1-154CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1, Fc tagged
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Cat.#:NRG1-171CTag:FC/His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1, His tagged
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Cat.#:NRG1-172CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1, Fc tagged
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Cat.#:NRG1-178CTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1
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Cat.#:NRG1-5693CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NRG1
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Cat.#:NRG1-4015ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NRG1
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Cat.#:NRG1-1280HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Neuregulin 1, HQ-tagged
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Cat.#:NRG1-1591HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 cell lysate
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Cat.#:NRG1-1592HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 cell lysate
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Cat.#:NRG1-1599HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 cell lysate
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Cat.#:NRG1-1675HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NRG1 cell lysate
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Cat.#:NRG1-001CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1 cell lysate
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Cat.#:NRG1-836CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NRG1 cell lysate
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Cat.#:NRG1-139HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human NRG1 Protein
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Involved Pathway

NRG1 involved in several pathways and played different roles in them. We selected most pathways NRG1 participated on our site, such as ErbB signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PRKCA; PAK6B; CAMK2B; BRAF; PAK1; MAP2K1; RPS6KB1; CAMK2D; AREGB; SHC1

Protein Function

NRG1 has several biochemical functions, for example, ErbB-2 class receptor binding, ErbB-3 class receptor binding, chemorepellent activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NRG1 itself. We selected most functions NRG1 had, and list some proteins which have the same functions with NRG1. You can find most of the proteins on our site.
Function
Related Protein
Function ErbB-2 class receptor binding
Related Protein MUC4; NRG1; CDK5
Function ErbB-3 class receptor binding
Related Protein NRG1; ERBB2; PIK3R1; CDK5
Function chemorepellent activity
Related Protein SEMA3H; UBE4A; SEMA3AB; SEMA6DL; EPHA7; SEMA3GB; SEMA3BL; SEMA6C; SEMA4C; NRG3
Function cytokine activity
Related Protein IFNA14; IFNPHI3; CCL6; WNT1; TGFB1A; CLCF1; Ifnz; Il1f9; Gm13290; Il23a; Il12b
Function growth factor activity
Related Protein IGF2B; FGF20; PSPN; FGF2; GDNFA; FGF16; BMP4; HBEGF; FGF18B; NENF
Function protein binding
Related Protein ARPC3; KRTAP4-2; MPP7; RAB5C; HM13; RBMS1; RIN3; CREB5; ROR1; DGKZ
Function protein tyrosine kinase activator activity
Related Protein NRG1; ABI1; GAS6; ERCC6; ABI3A; ERBB3; Cd24a; ABI1A; ABI1B; PAK2
Function receptor binding
Related Protein SMARCD3; HLA-G; HLA-F; ABL1; HAO1; NTF7; IFNL3; LGI1; UTS2; PCSK1N
Function receptor tyrosine kinase binding
Related Protein ARHGEF16; PLCG1; TP53; NRG1; NCK1; GAS6; ANXA5; FLT3LG; ANGPT2A; LRP4
Function transcription cofactor activity
Related Protein TFB2M; RFXANK; ZFP667; WDR75; TMF1; ZNF865; NFE2L1; MXD1; SLC26A3; MED13
Function transmembrane receptor protein tyrosine kinase activator activity
Related Protein NRG3; NRG1; EGF; GREM1; ANGPT4; EFNA5

Interacting Protein

NRG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NRG1.
EGFR; dnaE; q7cgr6_yerpe; CDC5L

NRG1 Related Articles

McCormick, ME; Collins, C; et al. Platelet Endothelial Cell Adhesion Molecule-1 Mediates Endothelial-Cardiomyocyte Communication and Regulates Cardiac Function. JOURNAL OF THE AMERICAN HEART ASSOCIATION 4:-(2015).
Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).