ntrk1
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  • Official Full Name
  • neurotrophic tyrosine kinase, receptor, type 1
  • Background
  • This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
  • Synonyms
  • NTRK1; neurotrophic tyrosine kinase, receptor, type 1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
Cat.#:NTRK1-2030HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1 Protein, Fc/His-tagged
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Cat.#:NTRK1-509RTag:His
Source (Host):HEK293Species:Rabbit
Product nameRecombinant Rabbit NTRK1 Protein, His-tagged
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Cat.#:NTRK1-108HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1, Fc Chimera
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Cat.#:NTRK1-448HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NTRK1, GST-tagged, Active
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Cat.#:Ntrk1-589RTag:Fc
Source (Host):NS0Species:Rat
Product nameRecombinant Rat TrkA, FC Chimera
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Cat.#:NTRK1-155HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1, Fc-His tagged
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Cat.#:NTRK1-156HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1, His tagged
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Cat.#:NTRK1-166HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human NTRK1, Fc Chimera
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Cat.#:NTRK1-296HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1 Protein, DDK/His-tagged
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Cat.#:NTRK1-297HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1 Protein, DDK/His-tagged
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Cat.#:NTRK1-31618THTag:
Source (Host):Species:Human
Product nameRecombinant Human NTRK1
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Cat.#:NTRK1-31619THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human NTRK1, Fc-tagged
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Cat.#:NTRK1-717HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NTRK1, GST-His
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Cat.#:NTRK1-86HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human NTRK1 protein, Flag-tagged, Biotinylated
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Cat.#:NTRK1-973HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NTRK1, His tagged
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Cat.#:NTRK1-977HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1, His tagged
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Cat.#:NTRK1-415MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ntrk1, His tagged
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Cat.#:NTRK1-476MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ntrk1, Fc tagged
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Cat.#:NTRK1-4102RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NTRK1 Protein
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Cat.#:Ntrk1-44RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ntrk1, Fc tagged
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Cat.#:Ntrk1-45RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ntrk1, His tagged
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Cat.#:NTRK1-295CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NTRK1, His tagged
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Cat.#:NTRK1-296CTag:FC/His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NTRK1, Fc tagged
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Cat.#:NTRK1-6930CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NTRK1
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Cat.#:NTRK1-8470ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NTRK1
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Cat.#:NTRK1-495HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human NTRK1, Fc-tagged
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Cat.#:NTRK1-2147HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NTRK1 cell lysate
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Cat.#:NTRK1-1086MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse NTRK1 cell lysate
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Cat.#:NTRK1-1068RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat NTRK1 cell lysate
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Cat.#:NTRK1-963CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine NTRK1 cell lysate
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Cat.#:Kit-1546Tag:
Source (Host):Species:
Product nameU2OS TrkA Bioassay Kit
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Cat.#:Kit-1627Tag:
Source (Host):Species:
Product nameTrkA Functional Assay Kit
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Involved Pathway

NTRK1 involved in several pathways and played different roles in them. We selected most pathways NTRK1 participated on our site, such as MAPK signaling pathway, Endocytosis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NTRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
SRF; RELA; FGF6; PDGFA; CACNB1; MAP3K4; RPS6KA3A; C11orf52; MAP3K2; PRKCA
Endocytosis
RNF103-CHMP3; GRK5; MVB12B; IGF1R; HSPA8; VPS37B; GIT2B; ACAP2; IL2RA; AP2M1B
Apoptosis
PRKAR2AA; HRK; YWHAQ; AKT2; Gzmg; NFKB1; CDKN2A; GAS2; MYD88; IRF1B
Neurotrophin signaling pathway
RPS6KA1; BRAF; BAX; GAB1; MAP2K2; CALM3; NGFR; MAPKAPK2; MAP3K5; NGFRAP1
Inflammatory mediator regulation of TRP channels
PLCG2; MAPK9; PIK3CG; PIK3R5; CYP2C55; PLCB1; ACCN5; PLA2G4A; ASIC4; CYP2C38
Pathways in cancer
WNT6; GNB4; PRKACG; WNT11; GRB2; PRKACB; BRAF; F2RL3; RAC1; FZD2
Transcriptional misregulation in cancer
IGF1; PLAU; SPINT1; CCNT2; PML; TRP53; SIX4; FOXO1; RARA; RUNX1T1
Thyroid cancer
MAP2K1; BRAF; TPM3; CCND1; TCF7; PPARG; RXRB; CDH1; RET; RXRA
Central carbon metabolism in cancer
HRAS; SLC16A3; SLC2A2; LDHA; FLT3; PTEN; KRAS; AKT2; SIRT6; G6PD

Protein Function

NTRK1 has several biochemical functions, for example, ATP binding, ephrin receptor binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NTRK1 itself. We selected most functions NTRK1 had, and list some proteins which have the same functions with NTRK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMOK2B; Ckmm; MYH9; ROS1; PRKCDA; RARS; ATP6V1BA; DDR2; RTCB; GSS
Function ephrin receptor binding
Related Protein EPHA4; Anks1; EFNA1B; EFNB2; ANKS1B; EFNA1A; SIPA1L1; EFNB3; EFNA4; EFNA3
Function kinase binding
Related Protein MOB4; BTG1; RB1; CEBPA; PARK2; ATF5; MIDN; JAKMIP2; HAP1; WWC1
Function nerve growth factor binding
Related Protein PCSK6; NGFRB; NTRK1; NGFR; FURIN; SORT1
Function NOT nerve growth factor binding
Related Protein NTRK1
Function nerve growth factor receptor activity
Related Protein NTRK1; SORT1
Function neurotrophin binding
Related Protein NGFR; NTRK2; NTRK1; NTRK3
Function neurotrophin p75 receptor binding
Related Protein NRADD; NTF3; NTRK1; ZFP110
Function protein binding
Related Protein BAG3; NAA16; CCT5; MAGED1; GSK3A; DMKN; IFNA4; LRSAM1; CEBPA; MS4A12
Function protein homodimerization activity
Related Protein TARBP2; CRYAB; PYGL; NR6A1; TOP2A; DAPK3; FLT3; CEBPA; CD247; IRAK1
Function transmembrane receptor protein tyrosine kinase activity
Related Protein FGFR1B; DDR1; EPHA4B; ALK; EPHA2; NTRK3A; KIT; ERBB4; IGF1RB; TRIM27

Interacting Protein

NTRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NTRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NTRK1.
NGF; NGF; Pirb; PLCG1; PIK3R1; SHC1; SORT1; PTPRC; PTPN1

NTRK1 Related Articles

Pajtler, KW; Mahlow, E; et al. Neuroblastoma in dialog with its stroma: NTRK1 is a regulator of cellular cross-talk with Schwann cells. ONCOTARGET 5:11180-11192(2014).
Youssef, G; Gillett, C; et al. Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: A potential novel prognostic marker for breast cancer. MODERN PATHOLOGY 27:361-374(2014).