Recombinant Full Length Human NTRK1 Protein, C-Flag-tagged

• Cat.No.: NTRK1-1505HFL
• Product Overview: Recombinant Full Length Human NTRK1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 86.7 kDa
• AA Sequence: MLRGGRRGQLGWHSWAAGPGSLLAW LILASAGAAPCPDACCPHGSSGLRC TRDGALDSLHHLPGAENLTE LYIENQQHLQHLELRDLRGLGELRN LTIVKSGLRFVAPDAFHFTPRLSRL NLSFNALESLSWKTVQGLSL QELVLSGNPLHCSCALRWLQRWEEE GLGGVPEQKLQCHGQGPLAHMPNAS CGVPTLKVQVPNASVDVGDD VLLRCQVEGRGLEQAGWILTELEQS ATVMKSGGLPSLGLTLANVTSDLNR KNLTCWAENDVGRAEVSVQV NVSFPASVQLHTAVEMHHWCIPFSV DGQPAPSLRWLFNGSVLNETSFIFT EFLEPAANETVRHGCLRLNQ PTHVNNGNYTLLAANPFGQASASIM AAFMDNPFEFNPEDPIPDTNSTSGD PVEKKDETPFGVSVAVGLAV FACLFLSTLLLVLNKCGRRNKFGIN RPAVLAPEDGLAMSLHFMTLGGSSL SPTEGKGSGLQGHIIENPQY FSDACVHHIKRRDIVLKWELGEGAF GKVFLAECHNLLPEQDKMLVAVKAL KEASESARQDFQREAELLTM LQHQHIVRFFGVCTEGRPLLMVFEY MRHGDLNRFLRSHGPDAKLLAGGED VAPGPLGLGQLLAVASQVAA GMVYLAGLHFVHRDLATRNCLVGQG LVVKIGDFGMSRDIYSTDYYRVGGR TMLPIRWMPPESILYRKFTT ESDVWSFGVVLWEIFTYGKQPWYQL SNTEAIDCITQGRELERPRACPPEV YAIMRGCWQREPQQRHSIKD
  VHARLQALAQAPPVYLDVLGTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer

Gene Information

• Gene Name: NTRK1 neurotrophic receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: NTRK1
• Synonyms: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
• Gene ID: 4914
• mRNA Refseq: NM_001012331.2
• Protein Refseq: NP_001012331.1
• MIM: 191315
• UniProt ID: P04629