Recombinant Rabbit NTRK1 Protein, His-tagged, Alexa Fluor 488 conjugated
Cat.No. : | NTRK1-509RAF488 |
Product Overview : | Alexa Fluor 488 conjugated recombinant Rabbit NTRK1 (XP_008262512.1) (Ala33-Glu414) was expressed with a polyhistidine tag at the C-terminus. |
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Description : | TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been ass centigradeiated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the n centigradeiceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma. |
Source : | HEK293 |
Species : | Rabbit |
Tag : | His |
Form : | Lyophilized |
Molecular Mass : | 43.4 kDa |
Protein length : | Ala33-Glu414, 393 |
N-terminal Sequence Analysis : | Ala 33 |
Endotoxin : | < 1.0 EU/ μg protein as determined by the LAL method. |
Purity : | > 95 % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Storage : | Samples are stable for up to twelve months from date of receipt at -70 centigrade. Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents. |
Gene Name : | NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Oryctolagus cuniculus ] |
Official Symbol : | NTRK1 |
Synonyms : | NTRK1; neurotrophic tyrosine kinase, receptor, type 1; |
Gene ID : | 100354292 |
Products Types
◆ Recombinant Protein | ||
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NTRK1-01H | Active Recombinant Human NTRK1 Protein (34-407), Animal free | +Inquiry |
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◆ Lysates | ||
NTRK1-1068RCL | Recombinant Rat NTRK1 cell lysate | +Inquiry |
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NTRK1-2147HCL | Recombinant Human NTRK1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1546 | U2OS TrkA Bioassay Kit | +Inquiry |
Kit-1627 | TrkA Functional Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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