| Description : |
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Bio-activity : |
Fully biologically active determined by its ability to inhibit NGF-beta dependent proliferation of TF-1 cells. ED50 is ≤ 242.2 ng/mL, corresponding to a specific activity of 4.13 × 10^3 units/mg. |
| Molecular Mass : |
41 kDa |
| Protein Length : |
34-407 |
| AA Sequence : |
APCPDACCPHGSSGLRCTRDGALDS LHHLPGAENLTELYIENQQHLQHLE LRDLRGLGELRNLTIVKSGLRFVAP DAFHFTPRLSRLNLSFNALESLSWK TVQGLSLQELVLSGNPLHCSCALRW LQRWEEEGLGGVPEQKLQCHGQGPL AHMPNASCGVPTLKVQVPNASVDVG DDVLLRCQVEGRGLEQAGWILTELE QSATVMKSGGLPSLGLTLANVTSDL NRKNVTCWAENDVGRAEVSVQVNVS FPASVQLHTAVEMHHWCIPFSVDGQ PAPSLRWLFNGSVLNETSFIFTEFL EPAANETVRHGCLRLNQPTHVNNGN YTLLAANPFGQASASIMAAFMDNPF EFNPEDPIPVSFSPVDTNSTSGDP |
| Endotoxin : |
<= 0.005 Eu/μg |
| Purity : |
>= 95% HPLC |
| Applications : |
MS, HPLC, SDS-PAGE, Functional Studies |
| Notes : |
This product is an active protein and may elicit a biological response in vivo, handle with caution. |
| Storage : |
Store at Room Temperature. |
| Storage Buffer : |
0.727% Dibasic monohydrogen potassium phosphate, 0.248% Monobasic dihydrogen potassium phosphate, 10.26% Trehalose, pH: 7.40 |
| Reconstitution : |
Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product. Store lyophilized form at room temperature. Reconstitute in phosphate buffered saline, aliquot and store at -80 centigrade for 12 months or 4 centigrade for 1 week. Avoid repeated freeze-thaw. |
| Shipping : |
Shipped at Room Temperature. |
