Recombinant Human NTRK1, Fc-tagged
Cat.No. : | NTRK1-31619TH |
Product Overview : | Recombinant fragment corresponding to amino acids 33-405 of Human TrkA fused to the Fc region of human IgG1 expressed in modified human 293 cells. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. |
Conjugation : | Fc |
Tissue specificity : | Isoform TrkA-II is primarily expressed in neuronal cells; isoform TrkA-I is found in non-neuronal tissues. |
Form : | Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
Storage : | Shipped at 4°C. After reconstitution store at -20oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | Theoretical sequence:AAPCPDACCPHGSSGLRCTRDGALDSLHH LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIV KSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQG LSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKL QCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRC QVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLAN VTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLH TAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIF TEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF GQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSE IPKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCRV SNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYT QKSLSLSPGK |
Sequence Similarities : | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 protein kinase domain. |
Gene Name : | NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ] |
Official Symbol : | NTRK1 |
Synonyms : | NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA; |
Gene ID : | 4914 |
mRNA Refseq : | NM_001007792 |
Protein Refseq : | NP_001007793 |
MIM : | 191315 |
Uniprot ID : | P04629 |
Chromosome Location : | 1q21-q22 |
Pathway : | ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Endocytosis, organism-specific biosystem; |
Function : | ATP binding; neurotrophin binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
NTRK1-01H | Active Recombinant Human NTRK1 Protein (34-407), Animal free | +Inquiry |
Ntrk1-4522M | Recombinant Mouse Ntrk1 Protein, Myc/DDK-tagged | +Inquiry |
Ntrk1-45R | Active Recombinant Rat Ntrk1 protein(Met1-Pro418), His-tagged | +Inquiry |
NTRK1-415M | Active Recombinant Mouse NTRK1 protein(Met1-Gly420), His-tagged | +Inquiry |
NTRK1-1322C | Acitve Recombinant Canine NTRK1 protein(Pro285-Lys410), hFc-tagged | +Inquiry |
◆ Lysates | ||
NTRK1-963CCL | Recombinant Canine NTRK1 cell lysate | +Inquiry |
NTRK1-1068RCL | Recombinant Rat NTRK1 cell lysate | +Inquiry |
NTRK1-2147HCL | Recombinant Human NTRK1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1627 | TrkA Functional Assay Kit | +Inquiry |
Kit-1546 | U2OS TrkA Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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