Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human NTRK1, Fc-tagged

Cat.No. : NTRK1-31619TH
Product Overview : Recombinant fragment corresponding to amino acids 33-405 of Human TrkA fused to the Fc region of human IgG1 expressed in modified human 293 cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Conjugation : Fc
Tissue specificity : Isoform TrkA-II is primarily expressed in neuronal cells; isoform TrkA-I is found in non-neuronal tissues.
Form : Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
Storage : Shipped at 4°C. After reconstitution store at -20oC. Avoid freeze / thaw cycles.
Sequences of amino acids : Theoretical sequence:AAPCPDACCPHGSSGLRCTRDGALDSLHH LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIV KSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQG LSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKL QCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRC QVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLAN VTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLH TAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIF TEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF GQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSE IPKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCRV SNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKN QVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYT QKSLSLSPGK
Sequence Similarities : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 2 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 protein kinase domain.
Gene Name : NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [ Homo sapiens ]
Official Symbol : NTRK1
Synonyms : NTRK1; neurotrophic tyrosine kinase, receptor, type 1; high affinity nerve growth factor receptor; MTC; TRK; TRKA;
Gene ID : 4914
mRNA Refseq : NM_001007792
Protein Refseq : NP_001007793
MIM : 191315
Uniprot ID : P04629
Chromosome Location : 1q21-q22
Pathway : ARMS-mediated activation, organism-specific biosystem; Activation of TRKA receptors, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Endocytosis, organism-specific biosystem;
Function : ATP binding; neurotrophin binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All NTRK1 Products

Required fields are marked with *

My Review for All NTRK1 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends