pdgfb
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  • Official Full Name
  • platelet-derived growth factor beta polypeptide
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
  • Synonyms
  • PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Cat.#:PDGFB-377HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB Protein, His & Avi-tagged, Unconjugated
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Cat.#:PDGFB-515HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFB Protein, His-tagged
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Cat.#:PDGFB-516MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein, His-tagged
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Cat.#:PDGFB-924CTag:His
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFB Protein (Ser82-Thr190), His-tagged
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Cat.#:PDGFB-977RTag:His
Source (Host):YeastSpecies:Rhesus
Product nameRecombinant Rhesus PDGFB Protein (Ser82-Thr190), His-tagged
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Cat.#:PDGFB-4402MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:PDGFB-4385CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFB Protein
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Cat.#:PDGFB-4383BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine PDGFB Protein
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Cat.#:PDGFB-4406CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken PDGFB Protein
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Cat.#:PDGFB-4403FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline PDGFB Protein
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Cat.#:PDGFB-4410ETag:
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine PDGFB Protein
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Cat.#:PDGFA&PDGFB-17HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGF-AB
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Cat.#:PDGFB-146HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-1610HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-168HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human PDGFB Protein, Biotinylated
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Cat.#:PDGFB-171HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF18 protein, His/S-tagged
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Cat.#:PDGFB-20HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-30560THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-312HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB protein, Animal-Free
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Cat.#:PDGFB-31597THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Human PDGFA
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Cat.#:PDGFB-471HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-524HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-528HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-529HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human PDGFBB
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Cat.#:PDGFB-12568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:Pdgfb-172MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-55MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb
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Cat.#:Pdgfb-638MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His & GST-tagged
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Cat.#:Pdgfa&Pdgfb-216RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa&Pdgfb
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Cat.#:Pdgfb-173RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-639RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His & GST-tagged
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Cat.#:PDGFB-209CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PDGFB, Fc-tagged
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Cat.#:PDGFB-5843CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFB
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Cat.#:PDGFB-035ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB (82-190aa)
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Cat.#:PDGFB-661HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Beta Polypeptide
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Cat.#:PDGFB-1321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB cell lysate
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Cat.#:PDGFB-125HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB Protein
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Cat.#:PDGFB-4346HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB protein
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Cat.#:PDGFBB-141HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-derived Growth Factor-BB (rDNA derived) Reference standard
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Cat.#:PDGFB-P055HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFB therapeutic protein
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Involved Pathway

PDGFB involved in several pathways and played different roles in them. We selected most pathways PDGFB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K6; GNG12A; MAP2K4B; FGF18; AKT3A; RASGRF2B; PPP3R1; HSPA1L; GADD45G; STK4
Ras signaling pathway
PLA2G10; FGF16; RAF1; RELA; RASGRF2; PDGFB; MET; PIK3R3; FLT1; RASSF1
Rap signaling pathway
RAF1; RAPGEF5; ANGPT2; FGF12; PRKD2; FGF10; GNAI3; FARP2; CALML5; AKT2
Cytokine-cytokine receptor interaction
TNFRSF10B; KITLGA; CCR1L1; GM-CSF; IL15RA; TNFRSF14; IL20RA; INHBE; PDGFRB; IL2RG
Phospholipase D signaling pathway
GRM7; Adcy4; PDGFRB; PDGFB; FYN; PDGFRA; GRM4; GNA12; GAB1; PLCG1
PIK-Akt signaling pathway
NOS3; IL2RA; Ifna11; GRB2; ANGPT1; IFNA12; NR4A1; NRAS; LPAR6; PIK3R5
Focal adhesion
Pdgfa&Pdgfb; MAPK10; PIK3CB; PIK3CG; FN1A; Itga10&Itgb1; FN1; PDGFA; PDGFAA; RAF1A
Gap junction
CSNK1DB; TUBB; PRKACB; TUBB2; Adcy4; PRKACG; HTR2C; TUBA3C; SOS1; HTR2CL1
Regulation of actin cytoskeleton
FN1; PIP5K1A; ITGA1; ARPC4L; FGF8A; MLCK2; RDX; MYL12.2; ITGB3B; ARPC5A
HTLV-I infection
ITGAL; FZD9; BUB1B; FZD8; VDAC1; STAT5A; WNT16; VDAC2; TBPL1; PPP3CB
Pathways in cancer
IKBKB; FGF17; WNT2; CTNNA3; AKT1; KRAS; MET; WNT1; PTCH1; NFKBIA
MicroRNAs in cancer
TGFB2; STAT3; MMP16; APC; CDC25B; BAK1; PLCG2; RECK; PIM1; THBS1
Renal cell carcinoma
PAK6; RAP1A; PAK2; PIK3R3; RBX1; PDGFB; MAPK3; ARAF; HRAS; RAPGEF1
Glioma
CAMK2D; SHC1; PIK3R5; CAMK2B; MAP2K2; KRAS; CALM1; PDGFB; MDM2; PDGFA
Prostate cancer
PIK3R2; CPN1; IGF1R; PDGFRA; SOS1; PDPK1; PIK3CG; SPINK1; PDGFB; PDGFRB
Melanoma
FGFR1; FGF22; FGF20; FGF14; FGF10; FGF3; PIK3CB; CDH1; FGF17; RB1
Choline metabolism in cancer
GRB2; PIK3R1; SOS1; PDGFRB; TSC2; PIK3CG; PDGFB; EIF4EBP1; PLA2G4C; DGKZ

Protein Function

PDGFB has several biochemical functions, for example, chemoattractant activity, collagen binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFB itself. We selected most functions PDGFB had, and list some proteins which have the same functions with PDGFB. You can find most of the proteins on our site.
Function
Related Protein
Function chemoattractant activity
Related Protein CCL5; CXCL12; PDGFB; VHL; BMP4; VEGFC; HMGB1; VEGFB; FGF10; LGALS3
Function collagen binding
Related Protein CTSK; CCBE1; CHADL; COMP; SMAD4; PAK1; SMAD7; CTSS; VWF; SERPINH1B
Function growth factor activity
Related Protein JAG2; HBEGF; INHBAB; FGF2; TGFB1A; MDK; Pdgfa&Pdgfb; FGF18A; GDF15; IL34
Function identical protein binding
Related Protein KCNJ2; MUL1A; VPS41; SUN2; IFIT3; RBM10; TNPO3; PHYKPL; C1S; DYNLT1A
Function platelet-derived growth factor binding
Related Protein COL6A1; PDGFA; PDGFB; PDGFRB; COL5A1; COL1A2; COL4A1; Pdgfa&Pdgfb; PDGFRA; COL2A1
Function platelet-derived growth factor receptor binding
Related Protein PDGFB; ITGA5; TYMP; LYN; IL1R1; PDGFRB; FIGF; PDGFC; PDGFD; VEGFA
Function protein binding
Related Protein DOT1L; PARP2; APLP2; MAP3K7; CCDC50; FAM21C; CLIC3; VPS54; GPRIN2; PPP2R3C
Function protein heterodimerization activity
Related Protein NR4A2; PDSS2; SYT10; USF1; HIST1H4K; CENPW; TAF6; NEFH; TOP2B; SRY
Function protein homodimerization activity
Related Protein BHLHB9; VPS25; AADAT; CORO1A; CADM2A; RPE; AMICA1; PVRL2L; HIF1AN; ADSSL1
Function superoxide-generating NADPH oxidase activator activity
Related Protein NCF4; PDGFB; AGT; NOXA1; NOXO1

Interacting Protein

PDGFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFB.
PDGFRB; PDGFRA

PDGFB Related Articles

Borkham-Kamphorst, E; Alexi, P; et al. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457:307-313(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).