pdgfb
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  • Official Full Name
  • platelet-derived growth factor beta polypeptide
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
  • Synonyms
  • PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Cat.#:PDGFB-4402MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:PDGFB-4385CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFB Protein
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Cat.#:PDGFB-4383BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine PDGFB Protein
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Cat.#:PDGFB-4406CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken PDGFB Protein
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Cat.#:PDGFB-4403FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline PDGFB Protein
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Cat.#:PDGFB-4410ETag:
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine PDGFB Protein
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Cat.#:PDGFA&PDGFB-17HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGF-AB
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Cat.#:PDGFB-146HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-1610HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-168HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human PDGFB Protein, Biotinylated
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Cat.#:PDGFB-171HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF18 protein, His/S-tagged
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Cat.#:PDGFB-20HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-30560THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-312HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB protein, Animal-Free
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Cat.#:PDGFB-31597THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Human PDGFA
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Cat.#:PDGFB-471HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-524HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-528HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-529HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human PDGFBB
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Cat.#:PDGFB-12568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:Pdgfb-172MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-55MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb
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Cat.#:Pdgfb-638MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His & GST-tagged
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Cat.#:Pdgfa&Pdgfb-216RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa&Pdgfb
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Cat.#:Pdgfb-173RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-639RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His & GST-tagged
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Cat.#:PDGFB-209CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PDGFB, Fc-tagged
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Cat.#:PDGFB-5843CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFB
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Cat.#:PDGFB-035ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB (82-190aa)
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Cat.#:PDGFB-661HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Beta Polypeptide
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Cat.#:PDGFB-1321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB cell lysate
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Cat.#:PDGFB-125HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB Protein
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Cat.#:PDGFB-4346HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB protein
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Cat.#:PDGFBB-141HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-derived Growth Factor-BB (rDNA derived) Reference standard
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Cat.#:PDGFB-P055HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFB therapeutic protein
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Cat.#:CSC-TP048Tag:
Source (Host):CHOSpecies:Human
Product nameHuman PDGFB Stable Cell Line-CHO
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Cat.#:CSC-TP079Tag:
Source (Host):YeastSpecies:Human
Product nameHuman PDGFB Stable Cell Line-Yeast
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Cat.#:CSC-P1028Tag:
Source (Host):Species:Human
Product nameAnti-Human PDGFB MAb Stable Cell Line-CHO
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Cat.#:CSC-P1029Tag:
Source (Host):Species:Human
Product nameAnti-Human PDGFB F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P1030Tag:
Source (Host):Species:Human
Product nameAnti-Human PDGFB scFv Stable Cell Line-CHO
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Involved Pathway

PDGFB involved in several pathways and played different roles in them. We selected most pathways PDGFB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FASLG; GNG12A; RELB; NFATC1; ZAK; FGF11A; SRFA; NTRK1; RPS6KA5; CACNA2D2
Ras signaling pathway
KLK1B4; GNB3; MAPK9; TEK; ANGPT2; PIK3R2; PIK3R1; KRAS; INS1; FGF5
Rap signaling pathway
PLCB4; PARD6A; MAGI1; MAPK13; INS2; TEK; GNAQ; VASP; IGF1R; PDGFRB
Cytokine-cytokine receptor interaction
IL25; TNFRSF9; Ccl9; GM2506; TNF; TNFB; Ifna15; IL28RA; IL5; IL28A
Phospholipase D signaling pathway
DGKD; INS1; GRM3; PIK3CB; Pdgfa&Pdgfb; AGTR1A; PDGFRA; RALGDS; PIK3R3; PDGFRB
PIK-Akt signaling pathway
FGF17; EIF4E2; VEGFA; TSC1; IFNA12; ITGA8; YWHAE; PGF; G6PC3; ITGA3
Focal adhesion
MAPK1; CAV1; PAK2B; VEGFB; CDC42L2; RAP1AA; CAV3; VASPA; COL1A1B; RAC1
Gap junction
DRD2A; ADRB3A; LPAR1; EGFRA; HTR2CL1; TUBAL3; KRAS; Adcy4; PRKACBA; PLCB1
Regulation of actin cytoskeleton
MYL2; FGD1; MYL1; FGF22; PAK7; RHOA; Itgam&Itgb2; GSNA; VCLA; FGD3
HTLV-I infection
ATF1; PPP3CB; RANBP3; PIK3CA; PTTG1; NFATC1; MAP2K4; ZFP36; POLE4; MAP3K3
Pathways in cancer
WNT2; FLT3; DAPK2; GNG10; FGF18; PLCB3; LAMA5; MITF; MAP2K1; FGF4
MicroRNAs in cancer
TNN; TRP63; NFKB1; IRS2; RECK; ABCB1A; MTOR; PLAU; SOCS1; PIM1
Renal cell carcinoma
PAK6; VEGFA; SOS1; CDC42; SLC2A1; EPAS1; HGF; MAP2K2; EGLN2; RAP1B
Glioma
AKT1; CCND1; PDGFA; MTOR; PDGFRA; PIK3R2; CAMK2G; CAMK2A; MAPK3; GRB2
Prostate cancer
MAPK1; SPINK1; TRP53; PIK3R2; CCNE1; RELA; RAF1; TGFA; RB1; MAP4K1
Melanoma
RB1; Pdgfa&Pdgfb; IGF1; FGF12; FGFR1; FGF22; FGF5; HGF; PIK3CD; CCND1
Choline metabolism in cancer
KRAS; PDPK1; PIP5K1C; PIP5K1B; DGKQ; DGKA; PRKCB; PLCG1; WASL; CHKA

Protein Function

PDGFB has several biochemical functions, for example, chemoattractant activity, collagen binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFB itself. We selected most functions PDGFB had, and list some proteins which have the same functions with PDGFB. You can find most of the proteins on our site.
Function
Related Protein
Function chemoattractant activity
Related Protein VEGFA; VEGFB; HGF; CXCL12B; CCL3; SAA4; CXCL12A; CCL15; VEGFC; FGF8
Function collagen binding
Related Protein NID2; PCOLCE; LRRC15; VWF; CTSK; MRC2; SRGN; ABI3BP; USH2A; Pdgfa&Pdgfb
Function growth factor activity
Related Protein BTC; LEP; VEGFA; GDNFA; BMP7B; MSTNA; FGF1B; NDR1; FBRS; FGF18B
Function identical protein binding
Related Protein CCDC155; MAPK1IP1; PLN; EIF2AK3; PPP5C; KHDRBS1; PLK4; CUBN; NIF3L1; CBLL1
Function platelet-derived growth factor binding
Related Protein COL6A1; COL4A1; COL3A1; COL1A1; PDGFRA; Pdgfa&Pdgfb; COL1A2; COL2A1; PDGFRB; PDGFA
Function platelet-derived growth factor receptor binding
Related Protein PDGFD; PDGFC; PTEN; PDGFAB; PDGFRA; FIGF; TYMP; VEGFA; LYN; ITGA5
Function protein binding
Related Protein DAPK2; DOK4; NPM1; AQP5; EPHA2; AAGAB; PLEKHG6; C14orf93; SF1; C12orf68
Function protein heterodimerization activity
Related Protein TCF3B; GABPA; HIST1H2BF; HIST1H47; SNX2; ATF3; PANX1; DR1; RARA; SMC2
Function protein homodimerization activity
Related Protein BHLHA15; HEXB; ANXA1; APOBEC3G; CSF1; TYW5; MFF; CRTAM; ZBTB4; MSH2
Function superoxide-generating NADPH oxidase activator activity
Related Protein NOXA1; NCF4; PDGFB; AGT; NOXO1

Interacting Protein

PDGFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFB.
PDGFRB; PDGFRA

PDGFB Related Articles

Borkham-Kamphorst, E; Alexi, P; et al. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457:307-313(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).