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PDGFB

  • Official Full Name

    platelet-derived growth factor beta polypeptide

  • Overview

    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
  • Synonyms

    PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog);

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canine
  • Chicken
  • Cynomolgus
  • Equine
  • Feline
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human
  • Mammalian Cell
  • Mammalian cells
  • P. pastoris
  • S.cerevisiae
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • SUMO
  • N/A
  • N
  • mFc
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDGFB-524H Active Recombinant Human PDGFB HEK293 N/A
Human PDGFB-312H Active Recombinant Human PDGFB protein, Animal-Free E.coli N/A
Human PDGFB-035E Active Recombinant Human PDGFB (82-190aa) E.coli N/A
Human PDGFA&PDGFB-17H Active Recombinant Human PDGF-AB E.coli N/A
Human PDGFB-146H Active Recombinant Human PDGFB HEK293 N/A
Human PDGFB-529H Active Recombinant Human PDGFB E.coli N/A
Human PDGFB-168H Active Recombinant Human PDGFB Protein, Biotinylated Mammalian cells N/A Ser82-Thr190
Human PDGFB-347HG Active GMP Recombinant Human PDGFB protein, His-tagged HEK293 His DNA sequence encoding Human PDGF-BB(GenBank: CAA45383.1) was expressed with His tag at the C-terminal.
Human PDGFB-20H Recombinant Human Platelet-Derived Growth Factor-BB E.coli N/A
Human PDGFB-58H Recombinant Human PDGFB, His-tagged E.coli His
Human PDGFB-661H Recombinant Human Platelet-Derived Growth Factor Beta Polypeptide Human N/A
Human PDGFB-59H Recombinant Human PDGFBB S.cerevisiae N/A
Human PDGFB-30560TH Recombinant Human PDGFB N/A
Human PDGFB-1610H Recombinant Human PDGFB, His-tagged E.coli His 1-241aa
Human PDGFB-528H Recombinant Human PDGFB protein E.coli N/A 110
Human PDGFB-471H Recombinant Human Platelet-Derived Growth Factor-BB Yeast N/A
Human PDGFB-31597TH Recombinant Human Human PDGFA E.coli N/A
Human PDGFB-171H Recombinant Human TNFSF18 protein, His/S-tagged E.coli His/S
Human PDGFB-1321HCL Recombinant Human PDGFB cell lysate N/A
Human PDGFB-1174H Recombinant Human PDGFB Protein, His-tagged HEK293F N-His Ser82-Thr190
Human PDGFB-4346HG GMP Recombinant Human PDGFB protein E.coli N/A 110
Human PDGFB-095H Active Recombinant Human PDGFB Protein E. coli
Human PDGFB-P055H Recombinant Human PDGFB therapeutic protein Yeast N/A 109 Aa
Human PDGFB-523H Recombinant Human PDGFB Protein 241
Human PDGFB-14H Active Recombinant Human PDGFB Protein, Pre-aliquoted E.coli Ser82-Thr190
Human PDGFB-3325H Recombinant Human PDGFB protein, His-SUMO-tagged E.coli His-SUMO 82-190aa
Human PDGFB-301367H Recombinant Human PDGFB protein, GST-tagged E.coli GST Asn36-Thr190
Human PDGFB-3161H Recombinant Human PDGFB Protein (Ser82-Thr190), His tagged E.coli His Ser82-Thr190
Human PDGFB-2571H Recombinant Human PDGFB Protein, His-tagged E.coli N-His Glu21-Ala241
Human PDGFB-3326H Recombinant Human PDGFB protein, His-tagged E.coli His 82-190aa
Human PDGFB-45H Active Recombinant Human PDGFB Protein E.coli
Human PDGFBB-141H Recombinant Human Platelet-derived Growth Factor-BB (rDNA derived) Reference standard E.coli N/A
Human PDGFB-153P Active Recombinant Human PDGFBB Protein (218 aa) P. pastoris 218
Human PDGFB-33H Recombinant Human PDGFB Protein E.coli
Human PDGFB-377H Active Recombinant Human PDGFB protein, His-Avi-tagged E.coli His-Avi Ser 82 - Thr 190
Human PDGFB-125HG Active GMP Recombinant Human PDGFB Protein E.coli N/A
Human PDGFB-16HG Active Recombinant Human PDGFB Protein (Ser82-Thr190), GMP Grade, Animal-Free E.coli Ser82-Thr190
Human PDGFB-224H Active Recombinant Human PDGFB Protein E.coli
Human PDGFB-4470H-B Recombinant Human PDGFB Protein Pre-coupled Magnetic Beads HEK293
Human PDGFB-515H Active Recombinant Human PDGFB Protein, His-tagged Yeast His Ser82-Thr190
Human PDGFB-149H Active Recombinant Human PDGFB Protein E.coli Ser82-Thr190
Human PDGFB-060P Active Recombinant Human PDGFBB Protein (109 aa) E.coli 109
Human PDGFB-4470H Recombinant Human PDGFB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDGFB-4838H Recombinant Human PDGFB Protein (Glu21-Ala241), C-His tagged E.coli C-His Glu21-Ala241
Human PDGFB-4839H Recombinant Human PDGFB Protein (Ser82-Thr190) E.coli Tag Free Ser82-Thr190
Human PDGFB-4840H Recombinant Human PDGFB Protein (Ser82-Ser192), N-His tagged E.coli N-His Ser82-Ser192
Mouse Pdgfb-55M Recombinant Mouse Pdgfb protein E.coli N/A 109
Mouse Pdgfb-638M Recombinant Mouse Pdgfb protein, His & GST-tagged E.coli His/GST Glu21~Ala241 (Accession # P31240)
Mouse PDGFB-12568M Recombinant Mouse PDGFB Protein Mammalian Cell His
Mouse Pdgfb-172M Recombinant Mouse Pdgfb protein, His/S-tagged E.coli His/S
Mouse PDGFB-6595M-B Recombinant Mouse PDGFB Protein Pre-coupled Magnetic Beads HEK293
Mouse PDGFB-4402M Recombinant Mouse PDGFB Protein Yeast N/A 109aa
Mouse Pdgfb-4757M Active Recombinant Mouse Pdgfb Protein E. coli
Mouse PDGFB-6595M Recombinant Mouse PDGFB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDGFB-516M Active Recombinant Mouse PDGFB protein, His-tagged Yeast His Ser82-Thr190
Mouse PDGFB-225M Active Recombinant Mouse PDGFB Protein E.coli
Mouse Pdgfb-316P Active Recombinant Mouse Pdgfbb Protein (110 aa) E.coli 110
Rat Pdgfa&Pdgfb-216R Active Recombinant Rat Pdgfa&Pdgfb E.coli N/A
Rat Pdgfb-639R Recombinant Rat Pdgfb protein, His & GST-tagged E.coli His/GST Cys5~Lys225 (Accession # Q05028)
Rat Pdgfb-173R Recombinant Rat Pdgfb protein, His/S-tagged E.coli His/S
Rat Pdgfb-1931R Recombinant Rat Pdgfb Protein, His&GST-tagged E.coli N-His&GST Cys13-Ala241
Rat Pdgfb-975R Recombinant Rat Pdgfb protein E.coli N/A 109
Rat Pdgfb-315P Active Recombinant Rat Pdgfbb Protein (110 aa) E.coli 110
Rabbit PDGFB-99R Recombinant Rabbit PDGFB Protein Yeast
Bovine PDGFB-4383B Recombinant Bovine PDGFB Protein Yeast N/A 109aa
Canine PDGFB-924C Recombinant Canine PDGFB Protein (Ser82-Thr190), His-tagged Yeast His Ser82-Thr190
Canine PDGFB-4385C Recombinant Canine PDGFB Protein Yeast N/A 109aa
Cynomolgus PDGFB-209C Active Recombinant Cynomolgus PDGFB protein(Ser82-Thr190), mFc-tagged HEK293 N-mFc Ser82-Thr190
Equine PDGFB-4410E Recombinant Equine PDGFB Protein Yeast N/A 109aa
Feline PDGFB-4403F Recombinant Feline PDGFB Protein Yeast N/A 105aa
Rhesus PDGFB-977R Recombinant Rhesus PDGFB Protein (Ser82-Thr190), His-tagged Yeast His Ser82-Thr190
Pig PDGFB-1175P Recombinant Pig PDGFB Protein, His-tagged E.coli N-His RAGCLSLRVGVGPSASAALDGPPLPTLTEFPLPP+Gly84-Arg199+GNHSSRVC
Chicken PDGFB-5843C Recombinant Chicken PDGFB Mammalian Cell His
Chicken PDGFB-4406C Recombinant Chicken PDGFB Protein Yeast N/A 109aa
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDGFB Related Articles

What is PDGFB protein?

PDGFB (platelet derived growth factor subunit B) gene is a protein coding gene which situated on the long arm of chromosome 22 at locus 22q13. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. The PDGFB protein is consisted of 241 amino acids and its molecular mass is approximately 27.3 kDa.

What is the function of PDGFB protein?

PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells.

PDGFB Related Signaling Pathway

By binding to its receptor PDGFR, PDGFB activates downstream signaling pathways, including PI3K/Akt, MAPK/ERK and other pathways, thereby promoting biological processes such as cell proliferation, differentiation and migration. At the same time, PDGFB can activate NF-κB signaling pathway, TGF-β signaling pathway and inhibit Wnt/β-catenin signaling pathway, so as to regulate the biological behavior of cells.

PDGFB Related Diseases

Mutations in this gene are associated with meningioma, gastrointestinal stromal tumors(GISTs), osteosarcoma and other tumors. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. PDGFB is involved in nervous system development and repair, and is associated with neurological diseases such as white matter disease and multiple sclerosis.

PDGFB-9.jpg

Fig1. Possible mechanism of PDGFB pathogenesis in Ankylosing spondylitis (AS).

Bioapplications of PDGFB

As a therapeutic target, PDGFB can assist in the development of inhibitor drugs for related diseases. Several applications of PDGFB have been studied or are undergoing clinical trials.

High Purity

High Bioactivity

PDGFB-2.jpg

Fig2. Activity Data. (PDGFB-4346HG)

Case study 1: Weixin Meng, 2018

Thoracic aortic dissection (TAD) is a serious condition requiring urgent treatment to avoid catastrophic consequences. The inflammatory response is involved in the occurrence and development of TAD. This study aimed to determine whether expression of PDGF-B (a subunit of PDGF-BB) was increased in TAD patients. Full-thickness ascending aorta wall specimens from TAD patients (n = 15) and control patients (n = 10) were examined for expression of PDGF-B and its receptor (PDGFRB) and in terms of morphology, inflammation, and fibrosis. An increase in elastic fragments in the aorta wall might be responsible for inducing the activation and migration of macrophages to injured sites, leading to elevated expression of PDGF-B.

PDGFB-3.jpg

Fig1. Expression of platelet-derived growth factor B (PDGF-B) in ascending aorta wall.

PDGFB-4.jpg

Fig2. Expression levels of PDGF-B protein were significantly elevated in the outer DM in thoracic aortic dissection (TAD) patients compared with control aorta wall, as indicated by Western blot.

Case study 2: Zhicheng Zhang, 2024

Colon adenocarcinoma (COAD) is the most common malignancy of the digestive tract, which is characterized by a dismal prognosis. No effective treatment has been established presently, thus there is an urgent need to understand the mechanisms driving COAD progression. By constructing stable cell lines (KLF7 overexpression and knockdown) and using a series of cellular and molecular experiments, this study found that KLF7 is overexpressed in COAD tissues. Mechanistically, these findings reveal that KLF7 can specifically bind to the promoter region of PDGFB (TGGGTGGAG), thus promoting the transcription of PDGFB and increasing its secretion. And secreted PDGFB facilitates the progression of COAD by activating MAPK/ERK, PI3K/AKT, and JAK/STAT3 signaling pathways through PDGFRβ.

PDGFB-5.jpg

Fig3. Effects of PDGFB in KLF7 transient knockdown or control LoVo cells were determined by migration.

PDGFB-6.jpg

Fig4. KLF7 promotes COAD progression by activating the MAPK/ERK, PI3K/AKT, and JAK/STAT3 signaling pathways through PDGFB.

PDGFB-7.jpg

Fig1. Schematic model illustrating KLF7 promoting COAD progression. KLF7 is overexpressed in COAD and can bind to the promoter region of PDGFB to promote its secretion. (Zhicheng Zhang, 2024)

PDGFB-8.jpg

Fig2. Schematic illustration of the potential mechanism of gastric cancer with liver metastasis (GCLM). (Chuanfu Ren, 2023)

PDGFB involved in several pathways and played different roles in them. We selected most pathways PDGFB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFasl;FGF1B;CACNG6A;TNFRSF1A;FGF6B;MAP3K13;PTPN7;RAC2;PPP5C
Ras signaling pathwayNF1;PGF;INS1;FGF8;PAK6;PDGFRB;MAPK10;PIK3R3;PLA2G4D
Rap signaling pathwayINS1;FGF4;FGF22;LPAR2;GNAI1;PDGFC;LAT;ITGAM;CALM2
Cytokine-cytokine receptor interactionCCL15;CXCR4A;PF4V1;PF4;CCL11;OSMR;GHRA;CCL16;TNFB
Phospholipase D signaling pathwayGRM1;SHC1;PLCB4;PDGFRB;PLCB1;CYTH4;PDGFA;PLD1;GRB2
PIK-Akt signaling pathwayPDGFD;IL7R;ITGA3;FGF8;ITGA10;RXRA;YWHAZ;GNG11;PIK3CD
Focal adhesionITGB1A;SHC3;PIK3R5;VTNB;PTK6;PIK3R2;ACTN1;MYL2B;COL5A1
Gap junctionGNA11A;TUBA8L4;MAP3K2;TUBA1L2;HRASB;MAP2K2;TUBA3C;PLCB4;PLCB1
Regulation of actin cytoskeletonMYLK4;FGF13B;WASLB;FGF20B;FGFR1A;FGFR3;ROCK2A;PIK3R3;ITGA9
HTLV-I infectionWNT11;LCK;DVL2;IL1R1;BAX;TBPL2;ATF3;SRF;CD3D
Pathways in cancerEGLN1;GNG2;FGF10;TRAF1;NCOA4;PPARD;TRAF2;ITGAV;FGF8
MicroRNAs in cancerTNN;CCND2;PLCG2;DNMT3A;IRS2;WNT3A;IRS1;SIRT1;ABCC1
Renal cell carcinomaRAPGEF1;MAP2K2;PIK3CD;MAPK3;PIK3R5;RAC1;EP300;MAPK1;MAP2K1
GliomaARAF;PDGFB;CALM4;CALM1;SHC1;PRKCA;MAP2K2;CAMK2A;PDGFRA
Prostate cancerFOXA1;PDGFA;PIK3CD;BRAF;PDPK1;TCF7L2;BAD;SMARCA4;SPINK1
MelanomaAKT2;BRAF;PDGFRA;Fgf15;MAPK3;PIK3CG;TRP53;NRAS;FGF18
Choline metabolism in cancerLYPLA1;RPS6KB1;PDGFC;PDGFD;MAP2K1;DGKB;TAE1;RPS6KB2;PRKCA

PDGFB has several biochemical functions, for example, chemoattractant activity, collagen binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFB itself. We selected most functions PDGFB had, and list some proteins which have the same functions with PDGFB. You can find most of the proteins on our site.

Function Related Protein
chemoattractant activityCXCL12A;HMGB2;VEGFC;LGALS3;SAA4;SAA3;MIF;HMGB1;CCL16
collagen bindingANTXR1;CTSK;ADAM9;PAK1;SRGN;ACHE;CD44;SMAD4;GP5
growth factor activityVEGFAB;IL5;FIGF;GPI;Il2;FGF18;AREG;VEGFA;MANF
identical protein bindingPRDX1;CLDN17;ECI1;LCP1;DDX58;VIM;SERPINA1E;FAM108A1;CLDND
platelet-derived growth factor bindingCOL1A2;COL4A1;COL5A1;PDGFRA;COL3A1;PDGFRB;Pdgfa&Pdgfb;COL1A1;COL2A1
platelet-derived growth factor receptor bindingFIGF;PTPRJ;PDGFRB;PDGFA;PDGFD;PDGFB;PTEN;PDGFAA;ITGA5
protein bindingMAPK11;TRIM55;ASCC1;MBD4;CDX4;CHUK;DNM1;FAM50B;TUBB2B
protein heterodimerization activityCEBPG;HIST1H3C;TLR1;TAS1R1;CUL3;SYT16;MEF2C;PIK3R1;BNIP3
protein homodimerization activityBOK;NR0B2;NAGA;PLCB1;UGT1A4;USH2A;BMP2B;BOKA;ABP1
superoxide-generating NADPH oxidase activator activityNOXA1;PDGFB;AGT;NCF4;NOXO1

PDGFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFB.

PDGFRB; PDGFRA

Borkham-Kamphorst, E; Alexi, P; et al. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457:307-313(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).
  • Q&As
  • Reviews

Q&As (7)

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In what capacity does PDGFB contribute to the intricate processes of angiogenesis and vascular remodeling? 07/26/2021

By potently stimulating the migratory and proliferative capabilities of smooth muscle cells and pericytes, PDGFB plays a pivotal role in regulating angiogenesis and orchestrating vascular remodeling events, thereby ensuring proper tissue perfusion and function.

How does PDGFB intricately contribute to the development and advancement of certain malignancies? 02/08/2020

PDGFB signaling assumes a critical role in fueling tumor growth, angiogenesis, and metastasis. PDGFB, acting through its activation of PDGFRβ, elicits a pro-tumorigenic cascade that promotes tumor cell proliferation, survival, migration, and invasion, while concurrently fueling tumor vascularization and distant metastatic spread.

In what ways is PDGFB implicated in the pathogenesis and progression of fibrotic disorders? 12/16/2018

PDGFB emerges as a significant contributor to the pathogenesis of fibrotic diseases by prompting fibroblast activation and proliferation. These dysregulated processes lead to excessive extracellular matrix deposition and subsequent tissue scarring. Furthermore, PDGFB exacerbates fibrosis through induction of myofibroblast differentiation.

What novel therapeutic avenues are being explored targeting the PDGFB/PDGFRβ signaling axis for interventional strategies? 06/28/2018

Promisingly, preclinical and clinical studies have investigated diverse approaches targeting the PDGFB/PDGFRβ signaling axis for therapeutic intervention in fibrotic disorders and certain neoplastic conditions. Inhibitors directed against PDGFB or PDGFRβ have exhibited considerable potential, effectively blocking downstream signaling cascades activated by PDGFB, thereby hampering cell proliferation and angiogenesis.

How does PDGFB actively participate in the intricate mechanisms governing wound healing and tissue regeneration? 10/22/2017

PDGFB, released by platelets and macrophages at inflammatory sites, acts as a key modulator in recruiting and activating fibroblasts. This activation not only promotes collagen synthesis but also initiates tissue remodeling, thus expediting the wound healing cascade and tissue integrity restoration.

What therapeutic strategies target PDGFB for disease treatment? 07/21/2017

Several therapeutic strategies aim to target PDGFB for disease treatment. Inhibitors of PDGFB, such as tyrosine kinase inhibitors, have been developed and used in clinical settings. These inhibitors can selectively block the activation of PDGF receptors and inhibit downstream signaling pathways, thereby suppressing excessive cell proliferation and migration. Additionally, approaches targeting PDGFB expression, such as gene therapy or RNA interference, hold promise as potential treatments for diseases associated with PDGFB dysregulation.

How does PDGFB orchestrate cellular proliferation and growth in diverse tissues and organs? 03/07/2016

PDGFB orchestrates cellular proliferative responses and drives growth by virtue of its ability to activate PDGFRβ, which in turn triggers downstream signaling cascades facilitating DNA synthesis and regulating critical cell cycle checkpoints.

Customer Reviews (3)

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Reviews
12/27/2018

    The seal of the reagent tubes is excellent, preventing evaporation and leakage.

    05/08/2018

      With its unique design and construction, the experimental reagent provides me with a fresh experimental experience.

      03/21/2016

        The stability of this reagent is exceptional, ensuring the reliability of the experiment.

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