pdgfb
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  • Official Full Name
  • platelet-derived growth factor beta polypeptide
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
  • Synonyms
  • PDGFB; platelet-derived growth factor beta polypeptide; SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2; platelet-derived growth factor subunit B; becaplermin; PDGF, B chain; PDGF subunit B; proto-oncogene c-Sis; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor, beta polypeptide (oncogene SIS); platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Cat.#:PDGFB-377HTag:His & Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB Protein, His & Avi-tagged, Unconjugated
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Cat.#:PDGFB-515HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFB Protein, His-tagged
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Cat.#:PDGFB-516MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein, His-tagged
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Cat.#:PDGFB-924CTag:His
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFB Protein (Ser82-Thr190), His-tagged
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Cat.#:PDGFB-977RTag:His
Source (Host):YeastSpecies:Rhesus
Product nameRecombinant Rhesus PDGFB Protein (Ser82-Thr190), His-tagged
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Cat.#:PDGFB-4402MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:PDGFB-4385CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFB Protein
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Cat.#:PDGFB-4383BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine PDGFB Protein
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Cat.#:PDGFB-4406CTag:
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken PDGFB Protein
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Cat.#:PDGFB-4403FTag:
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline PDGFB Protein
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Cat.#:PDGFB-4410ETag:
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine PDGFB Protein
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Cat.#:PDGFA&PDGFB-17HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGF-AB
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Cat.#:PDGFB-146HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-1610HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-168HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human PDGFB Protein, Biotinylated
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Cat.#:PDGFB-171HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFSF18 protein, His/S-tagged
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Cat.#:PDGFB-20HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-30560THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-312HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB protein, Animal-Free
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Cat.#:PDGFB-31597THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Human PDGFA
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Cat.#:PDGFB-471HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor-BB
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Cat.#:PDGFB-524HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-528HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-529HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB
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Cat.#:PDGFB-58HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB, His-tagged
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Cat.#:PDGFB-59HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human PDGFBB
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Cat.#:PDGFB-12568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFB Protein
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Cat.#:Pdgfb-172MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-55MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb
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Cat.#:Pdgfb-638MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfb protein, His & GST-tagged
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Cat.#:Pdgfa&Pdgfb-216RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa&Pdgfb
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Cat.#:Pdgfb-173RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His/S-tagged
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Cat.#:Pdgfb-639RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfb protein, His & GST-tagged
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Cat.#:PDGFB-209CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PDGFB, Fc-tagged
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Cat.#:PDGFB-5843CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFB
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Cat.#:PDGFB-035ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFB (82-190aa)
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Cat.#:PDGFB-661HTag:N/A
Source (Host):S. cerevisiaeSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Beta Polypeptide
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Cat.#:PDGFB-1321HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFB cell lysate
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Cat.#:PDGFB-125HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB Protein
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Cat.#:PDGFB-4346HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human PDGFB protein
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Cat.#:PDGFBB-141HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-derived Growth Factor-BB (rDNA derived) Reference standard
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Cat.#:PDGFB-P055HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFB therapeutic protein
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Involved Pathway

PDGFB involved in several pathways and played different roles in them. We selected most pathways PDGFB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NFATC1; DDIT3; TGFB1A; NFKB2; LRRK2; MEF2CB; ARR3B; MAP2K6; IL1A; CACNB3A
Ras signaling pathway
KSR2; PLD1; VEGFC; RASAL3; PLA2G4A; FLT4; GNG13; PTPN11; KSR1; Pdgfa&Pdgfb
Rap signaling pathway
LPAR4; PLCB2; VAV2; RASGRP3; F2RL3; FGF10; NGF; CALM4; FIGF; CALM2
Cytokine-cytokine receptor interaction
LEPB; TNFRSF10C; IFNE; IFNA1; IL1R2; TNFSF13; LTBR; BMPR1A; IL2RGB; PDGFC
Phospholipase D signaling pathway
PLCB2; GRM1; GAB2; PDGFD; RAF1; PIP5K1B; GRM3; AGPAT4; FCER1G; AVPR1A
PIK-Akt signaling pathway
IFNA2; GH2; COL4A1; GH1; LPAR2; CCND2; IKBKB; ITGA9; SOS1; GNG2
Focal adhesion
ITGA5; COL5A2A; PDPK1B; MYL12.1; COL6A5; RAC1B; RAPGEF1B; RAPGEF1; MAPK3; MYLPFB
Gap junction
PRKACAA; TUBA3B; HRASB; Pdgfa&Pdgfb; ADCY1B; GRB2B; PRKCBA; TUBB5; ADCY2B; TUBB2B
Regulation of actin cytoskeleton
ITGA6; ARHGEF7A; DIAPH3; FGFR3; CDC42L2; ITGA4; CYFIP1; FGF8A; FGF10; ARHGAP35
HTLV-I infection
CDC20; FZD2; PDGFRB; MAP3K1; PCNA; SLC25A31; CCND2; HLA-E; WNT2B; FZD6
Pathways in cancer
PTGER1; PIK3R5; GNB4; STK4; APPL1; WNT11; PLEKHG5; ARHGEF1; EGLN2; GNAS
MicroRNAs in cancer
MAP2K2; IGF2BP1; FOXP1; BCL2; PDGFRA; CCND1; CDC25B; ABCB1A; MAPK1; PDGFB
Renal cell carcinoma
MAPK1; PTPN11; AHA-1; AKT2; VHL; RAF1; RAPGEF1; SOS1; AKT1; GAB1
Glioma
TGFA; BRAF; PIK3R3; MAP2K1; RB1; PRKCA; KRAS; NRAS; PIK3R2; PIK3CA
Prostate cancer
PIK3CG; PIK3R2; FGFR2; RAF1; Pdgfa&Pdgfb; ACTL6B; FGFR1; TCF7L2; NFKBIA; CREB3L1
Melanoma
FGF9; FGFR1; FGF1; BAD; FGF17; MAP2K1; PTEN; PDGFA; PDGFB; IGF1
Choline metabolism in cancer
MAP2K2; GRB2; HRAS; PDGFRB; PIK3R5; MAPK1; DGKE; WASF3; KRAS; DGKZ

Protein Function

PDGFB has several biochemical functions, for example, chemoattractant activity, collagen binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFB itself. We selected most functions PDGFB had, and list some proteins which have the same functions with PDGFB. You can find most of the proteins on our site.
Function
Related Protein
Function chemoattractant activity
Related Protein MIF; CCL3; BMP4; SAA3; FGF7; FIGF; CCL16; HMGB2; VEGFB; PDGFB
Function collagen binding
Related Protein PCOLCE; DCN; DDR1; SPARC; LACRT; MTAP1A; CD44; TGFBI; NID1; Itga10&Itgb1
Function growth factor activity
Related Protein OSM; CD320; WISP3; AREG; BMP16; GDF3; NENF; NTF4; FGF20A; KITLG
Function identical protein binding
Related Protein TTR; RUVBL2; ATL3; G6PDX; CLDNG; DYNLRB1; BAG2; KDM6A; CLDN3; SOD1
Function platelet-derived growth factor binding
Related Protein COL2A1; PDGFRA; Pdgfa&Pdgfb; COL1A2; PDGFB; COL1A1; COL3A1; COL5A1; PDGFA; COL6A1
Function platelet-derived growth factor receptor binding
Related Protein ITGB3; PDGFD; FIGF; LYN; VEGFA; PDGFRB; PDGFC; PTPRJ; Pdgfa&Pdgfb; PDGFB
Function protein binding
Related Protein Anks6; PRPF31; SDC4; FAM86C; HSPA9; ADAM1B; COA5; TNIK; CYCS; BNIP1
Function protein heterodimerization activity
Related Protein SEPHS1; RXRA; ATP4A; NFKB1; CEBPE; CASP8; GCLC; MAFG; TAF6; GCLM
Function protein homodimerization activity
Related Protein MECOM; MZF1; SYT10; G6PD; SRR; ABCG2; SLC4A1; ODZ4; ATPIF1A; NUDT16
Function superoxide-generating NADPH oxidase activator activity
Related Protein NOXA1; PDGFB; AGT; NCF4; NOXO1

Interacting Protein

PDGFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFB here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFB.
PDGFRB; PDGFRA

PDGFB Related Articles

Borkham-Kamphorst, E; Alexi, P; et al. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 457:307-313(2015).
Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).