Recombinant Rabbit PDGFB Protein
Cat.No. : | PDGFB-99R |
Product Overview : | The Rabbit PDGF-BB recombinant protein without tag was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
- Specification
- Gene Information
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Description : | PDGF is one of the numerous growth factors that regulate cell growth and division. It plays a significant role in angiogenesis. Platelet-derived growth factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by numerous cells including smooth muscle cells, activated macrophages, and endothelial cells. |
Source : | Yeast |
Species : | Rabbit |
Molecular Mass : | 12.2 kDa |
AA Sequence : | SLGSPTAAAEPAVIAECKTRTEVFE ISRRLIDRTNANFLVWPPCVEVQRC SGCCNNRHVQCRPTQVQLRPVQVRK IEIVRKKPTFKKATVTLEDHLACKC ETVAGVRPA(109) |
Applications : | The Rabbit PDGF-BB endotoxin-free recombinant protein can be used in cell culture, as an PDGF-BB ELISA Standard, and as a Western Blot Control. |
Gene Name : | PDGFB platelet derived growth factor subunit B [ Oryctolagus cuniculus (rabbit) ] |
Official Symbol : | PDGFB |
Synonyms : | PDGFB; platelet derived growth factor subunit B; platelet-derived growth factor subunit B; platelet-derived growth factor beta polypeptide |
Gene ID : | 100358772 |
mRNA Refseq : | XM_07342088 |
Protein Refseq : | XP_017197577 |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionBy potently stimulating the migratory and proliferative capabilities of smooth muscle cells and pericytes, PDGFB plays a pivotal role in regulating angiogenesis and orchestrating vascular remodeling events, thereby ensuring proper tissue perfusion and function.
PDGFB signaling assumes a critical role in fueling tumor growth, angiogenesis, and metastasis. PDGFB, acting through its activation of PDGFRβ, elicits a pro-tumorigenic cascade that promotes tumor cell proliferation, survival, migration, and invasion, while concurrently fueling tumor vascularization and distant metastatic spread.
PDGFB emerges as a significant contributor to the pathogenesis of fibrotic diseases by prompting fibroblast activation and proliferation. These dysregulated processes lead to excessive extracellular matrix deposition and subsequent tissue scarring. Furthermore, PDGFB exacerbates fibrosis through induction of myofibroblast differentiation.
Promisingly, preclinical and clinical studies have investigated diverse approaches targeting the PDGFB/PDGFRβ signaling axis for therapeutic intervention in fibrotic disorders and certain neoplastic conditions. Inhibitors directed against PDGFB or PDGFRβ have exhibited considerable potential, effectively blocking downstream signaling cascades activated by PDGFB, thereby hampering cell proliferation and angiogenesis.
PDGFB, released by platelets and macrophages at inflammatory sites, acts as a key modulator in recruiting and activating fibroblasts. This activation not only promotes collagen synthesis but also initiates tissue remodeling, thus expediting the wound healing cascade and tissue integrity restoration.
Several therapeutic strategies aim to target PDGFB for disease treatment. Inhibitors of PDGFB, such as tyrosine kinase inhibitors, have been developed and used in clinical settings. These inhibitors can selectively block the activation of PDGF receptors and inhibit downstream signaling pathways, thereby suppressing excessive cell proliferation and migration. Additionally, approaches targeting PDGFB expression, such as gene therapy or RNA interference, hold promise as potential treatments for diseases associated with PDGFB dysregulation.
PDGFB orchestrates cellular proliferative responses and drives growth by virtue of its ability to activate PDGFRβ, which in turn triggers downstream signaling cascades facilitating DNA synthesis and regulating critical cell cycle checkpoints.
Customer Reviews (3)
Write a reviewThe seal of the reagent tubes is excellent, preventing evaporation and leakage.
With its unique design and construction, the experimental reagent provides me with a fresh experimental experience.
The stability of this reagent is exceptional, ensuring the reliability of the experiment.
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