Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Rabbit PDGFB Protein

Cat.No. : PDGFB-99R
Product Overview : The Rabbit PDGF-BB recombinant protein without tag was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
  • Specification
  • Gene Information
  • Related Products
Description : PDGF is one of the numerous growth factors that regulate cell growth and division. It plays a significant role in angiogenesis. Platelet-derived growth factor is a dimeric glycoprotein composed of two A (-AA) or two B (-BB) chains or a combination of the two (-AB). Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also produced by numerous cells including smooth muscle cells, activated macrophages, and endothelial cells.
Source : Yeast
Species : Rabbit
Molecular Mass : 12.2 kDa
AA Sequence : SLGSPTAAAEPAVIAECKTRTEVFE ISRRLIDRTNANFLVWPPCVEVQRC SGCCNNRHVQCRPTQVQLRPVQVRK IEIVRKKPTFKKATVTLEDHLACKC ETVAGVRPA(109)
Applications : The Rabbit PDGF-BB endotoxin-free recombinant protein can be used in cell culture, as an PDGF-BB ELISA Standard, and as a Western Blot Control.
Gene Name : PDGFB platelet derived growth factor subunit B [ Oryctolagus cuniculus (rabbit) ]
Official Symbol : PDGFB
Synonyms : PDGFB; platelet derived growth factor subunit B; platelet-derived growth factor subunit B; platelet-derived growth factor beta polypeptide
Gene ID : 100358772
mRNA Refseq : XM_07342088
Protein Refseq : XP_017197577

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
In what capacity does PDGFB contribute to the intricate processes of angiogenesis and vascular remodeling? 07/26/2021

By potently stimulating the migratory and proliferative capabilities of smooth muscle cells and pericytes, PDGFB plays a pivotal role in regulating angiogenesis and orchestrating vascular remodeling events, thereby ensuring proper tissue perfusion and function.

How does PDGFB intricately contribute to the development and advancement of certain malignancies? 02/08/2020

PDGFB signaling assumes a critical role in fueling tumor growth, angiogenesis, and metastasis. PDGFB, acting through its activation of PDGFRβ, elicits a pro-tumorigenic cascade that promotes tumor cell proliferation, survival, migration, and invasion, while concurrently fueling tumor vascularization and distant metastatic spread.

In what ways is PDGFB implicated in the pathogenesis and progression of fibrotic disorders? 12/16/2018

PDGFB emerges as a significant contributor to the pathogenesis of fibrotic diseases by prompting fibroblast activation and proliferation. These dysregulated processes lead to excessive extracellular matrix deposition and subsequent tissue scarring. Furthermore, PDGFB exacerbates fibrosis through induction of myofibroblast differentiation.

What novel therapeutic avenues are being explored targeting the PDGFB/PDGFRβ signaling axis for interventional strategies? 06/28/2018

Promisingly, preclinical and clinical studies have investigated diverse approaches targeting the PDGFB/PDGFRβ signaling axis for therapeutic intervention in fibrotic disorders and certain neoplastic conditions. Inhibitors directed against PDGFB or PDGFRβ have exhibited considerable potential, effectively blocking downstream signaling cascades activated by PDGFB, thereby hampering cell proliferation and angiogenesis.

How does PDGFB actively participate in the intricate mechanisms governing wound healing and tissue regeneration? 10/22/2017

PDGFB, released by platelets and macrophages at inflammatory sites, acts as a key modulator in recruiting and activating fibroblasts. This activation not only promotes collagen synthesis but also initiates tissue remodeling, thus expediting the wound healing cascade and tissue integrity restoration.

What therapeutic strategies target PDGFB for disease treatment? 07/21/2017

Several therapeutic strategies aim to target PDGFB for disease treatment. Inhibitors of PDGFB, such as tyrosine kinase inhibitors, have been developed and used in clinical settings. These inhibitors can selectively block the activation of PDGF receptors and inhibit downstream signaling pathways, thereby suppressing excessive cell proliferation and migration. Additionally, approaches targeting PDGFB expression, such as gene therapy or RNA interference, hold promise as potential treatments for diseases associated with PDGFB dysregulation.

How does PDGFB orchestrate cellular proliferation and growth in diverse tissues and organs? 03/07/2016

PDGFB orchestrates cellular proliferative responses and drives growth by virtue of its ability to activate PDGFRβ, which in turn triggers downstream signaling cascades facilitating DNA synthesis and regulating critical cell cycle checkpoints.

Customer Reviews (3)

Write a review
Reviews
12/27/2018

    The seal of the reagent tubes is excellent, preventing evaporation and leakage.

    05/08/2018

      With its unique design and construction, the experimental reagent provides me with a fresh experimental experience.

      03/21/2016

        The stability of this reagent is exceptional, ensuring the reliability of the experiment.

        Ask a Question for All PDGFB Products

        Required fields are marked with *

        My Review for All PDGFB Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends