pf4
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  • Official Full Name
  • platelet factor 4
  • Background
  • This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]
  • Synonyms
  • PF4; platelet factor 4; PF-4; CXCL4; SCYB4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4
Cat.#:PF4-194HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet Factor 4
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Cat.#:PF4-150HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PF4 Protein, His-tagged
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Cat.#:PF4-1654HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PF4, GST-tagged
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Cat.#:PF4-52HTag:N/A
Source (Host):Human PlateletsSpecies:Human
Product nameHuman Platelet Factor 4
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Cat.#:PF4-590HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human platelet factor 4, His-tagged
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Cat.#:PF4-87HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PF4, None tagged
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Cat.#:Pf4-151MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pf4 Protein, His-tagged
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Cat.#:Pf4-152MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Platelet Factor 4
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Cat.#:Pf4-159MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pf4 Protein, His-tagged
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Cat.#:Pf4-611MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pf4
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Cat.#:Pf4-153RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pf4 Protein, His-tagged
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Cat.#:Pf4-154RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pf4 Protein, His/GST-tagged
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Cat.#:PF4-4388RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PF4 Protein
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Cat.#:PF4-253HTag:
Source (Host):Species:Human
Product nameNative Human Platelet Factor 4
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Cat.#:PF4-3283HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PF4 293 Cell Lysate
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Cat.#:PF4-71HTag:
Source (Host):Species:Human
Product nameHuman Platelet Factor 4(Purified) Reference standard
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Involved Pathway

PF4 involved in several pathways and played different roles in them. We selected most pathways PF4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
Fasl; CCR9A; CXCL1; IFNA17; IL15; Ifna11; PLEKHO2; KITLG; IFNPHI3; CXCL12A
Chemokine signaling pathway
SRC; PRKACG; GNG12; SHC1; GM13306; CCL3L3; STAT5B; RAP1A; RAP1B; PTK2B

Protein Function

PF4 has several biochemical functions, for example, CXCR3 chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PF4 itself. We selected most functions PF4 had, and list some proteins which have the same functions with PF4. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR3 chemokine receptor binding
Related Protein CXCL11; PF4; CXCL9; CXCL13; CXCL11.8; CXCL10
Function chemokine activity
Related Protein CCL35.2; CCL34B.1; CCL26; CCL17; CCL7; CCL4; CCL1; CXCL14; CCL19; CCL15
Function heparin binding
Related Protein VEGFAA; APOA5; PDCD5; PF4V1; RSPO3; FMOD; SLIT3; LIPI; AAMP; MSTN

Interacting Protein

PF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PF4.
PLEK; a41_vaccw

PF4 Related Articles

Luna, E; Agrawal, P; et al. Evaluation of Immunostimulatory Potential of Branded and US-Generic Enoxaparins in an In Vitro Human Immune System Model. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:211-222(2015).
Matsuo, T; Motohashi, S; et al. Production of Anti-platelet Factor 4/Heparin Complex Antibodies After Cardiovascular Surgery. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 21:177-180(2015).