|Official Full Name||proteinase 3|
|Background||PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.|
|Synonyms||MBN; MBT; NP4; P29; PR3; ACPA; AGP7; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; NP-4; EC 188.8.131.52; EC 3.4.21|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PRTN3 involved in several pathways and played different roles in them. We selected most pathways PRTN3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRTN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|C-MYB transcription factor network||TRIM28; COL1A2; PPID; MYB; CREBBP; CBX4; PIAS3; ADA; CLTA; MYOD1|
|Common Pathway of Fibrin Clot Formation||F13A1A.1; PROCA; SERPINE2; PROCR; CFHL2; SERPINA1L; CFHL1; CFHL4; PRTN3; CD177|
|Formation of Fibrin Clot (Clotting Cascade)||CFHL4; F13A1A.1; PROCR; F9A; CFHL2; CD177; F13A1B; F3A; LOC100514666; CFHL3|
|Hemostasis||TRPC3; TRPC7; CD9B; DOCK10; PDE10A; MERTK; SLC16A1; GRB14; KIF18A; S100A10A|
PRTN3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PRTN3 itself. We selected most functions PRTN3 had, and list some proteins which have the same functions with PRTN3. You can find most of the proteins on our site.
|enzyme binding||NOS1; TRAF2; RPS2; ZNHIT6; SNX12; CCND1; HIST1H2AD; Ar; HDAC3; RCOR3|
|serine-type endopeptidase activity||PRSS45; LOC100686744; PREPL; LONP1; GM5077; FURINB; PRSS12; C1RL; F11; KLK14|
|serine-type peptidase activity||GZMK; GZMC; HTRA1; TMPRSS2; DPP9; MCPT2; KLK1B11; ZFYVE9; PRSS52; PLG|
PRTN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRTN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRTN3.
SMAD3; A2M; P/V/C