prtn3
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  • Official Full Name
  • proteinase 3
  • Background
  • PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
  • Synonyms
  • MBN; MBT; NP4; P29; PR3; ACPA; AGP7; PR-3; CANCA; C-ANCA; myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen; proteinase 3; NP-4; EC 3.4.21.76; EC 3.4.21
Cat.#:PRTN3-1996HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRTN3 Protein, His-tagged
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Cat.#:PRTN3-31105THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRTN3
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Cat.#:PRTN3-45HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRTN3 protein, His-tagged
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Cat.#:PRTN3-13534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRTN3 Protein
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Cat.#:Prtn3-6958MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prtn3 protein, His-tagged
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Cat.#:Prtn3-6959RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prtn3 protein, His-tagged
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Cat.#:PRTN3-242HTag:
Source (Host):Human Azurophil GranulesSpecies:Human
Product nameNative Human Proteinase 3
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Cat.#:PRTN3-243HTag:
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameNative Human Proteinase 3
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Cat.#:PRTN3-2797HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRTN3 293 Cell Lysate
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Involved Pathway

PRTN3 involved in several pathways and played different roles in them. We selected most pathways PRTN3 participated on our site, such as C-MYB transcription factor network, Common Pathway of Fibrin Clot Formation, Formation of Fibrin Clot (Clotting Cascade), which may be useful for your reference. Also, other proteins which involved in the same pathway with PRTN3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
C-MYB transcription factor network
CREBBP; TRIM28; GATA1; SMARCA2; CSF1R; MYF6; PTCRA; PRTN3; PIAS3; ADORA2B
Common Pathway of Fibrin Clot Formation
F13A1B; CFHL2; SERPINE2; CFHL1; CFHL3; LOC100514666; F13A1A.1; PRTN3; CD177; SERPINA1L
Formation of Fibrin Clot (Clotting Cascade)
F3A; CD177; CFHL4; CFHL2; LOC100514666; F9A; CFHL3; PRTN3; F13A1B; CFHL1
Hemostasis
OSTN; BRPF3; HRG; F3A; CBX5; PLEK; GAS6; DOCK7; PDPN; LOC100514666

Protein Function

PRTN3 has several biochemical functions, for example, enzyme binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRTN3 itself. We selected most functions PRTN3 had, and list some proteins which have the same functions with PRTN3. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein HDAC2; RFC5; HIST1H2AK; APP; CPSF1; RPA2; HMOX1; CBS; CYP2C19; ERN1
Function serine-type endopeptidase activity
Related Protein CELA3B; PCSK9; TPSAB1; KLK7; PRSS45; KLK5; LOC780933; TPP2; KLK12; PRSS3
Function serine-type peptidase activity
Related Protein PRSS59.2; DPP8; ZFYVE9; PRSS48; KLK1B1; PRSS41; ELA3L; PRSS21; ELA2; PRSS16

Interacting Protein

PRTN3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRTN3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRTN3.
SMAD3; A2M; P/V/C

PRTN3 Related Articles

Alberici, F; Martorana, D; et al. Genetics of ANCA-associated vasculitides: HLA and beyond. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:S90-S97(2014).
Lyons, PA; Rayner, TF; et al. Genetically Distinct Subsets within ANCA-Associated Vasculitis. NEW ENGLAND JOURNAL OF MEDICINE 367:214-223(2012).