pdgfa
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  • Official Full Name
  • platelet-derived growth factor alpha polypeptide
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene
  • Synonyms
  • PDGFA; platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGF A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor subunit A; PDGF subunit A; Platelet-derived growth factor A chain; PDGF-1; OTTHUMP00000199955; OTTHUMP00000199956; platelet-derived growth factor alpha isoform 2 preproprotein
Cat.#:PDGFA-1608HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein, GST-tagged
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Cat.#:PDGFA-514MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFA Protein, His-tagged
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Cat.#:PDGFA-563HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFA Protein (Ser87-Thr211), His-tagged
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Cat.#:PDGFA-923CTag:His
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFA Protein (Ser87-Arg196), His-tagged
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Cat.#:PDGFA-940RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat PDGFA Protein (Ser87-Arg196), His-tagged
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Cat.#:PDGFA&PDGFB-17HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGF-AB
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Cat.#:PDGFA-047HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human PDGFA Protein
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Cat.#:PDGFA-121HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-1609HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA, GST-tagged
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Cat.#:PDGFA-174HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein, His/S-tagged
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Cat.#:PDGFA-375HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Platelet-derived Growth Factor AA
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Cat.#:PDGFA-523HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-54HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA, His-tagged
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Cat.#:PDGFA-56HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFAA
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Cat.#:PDGFA-57HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein
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Cat.#:Pdgfa-048MTag:
Source (Host):HEK293 cellsSpecies:Mouse
Product nameRecombinant Mouse Pdgfa Protein
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Cat.#:PDGFA-12567MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFA Protein
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Cat.#:Pdgfa-175MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa protein, His/S-tagged
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Cat.#:Pdgfa-298MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Platelet Derived Growth Factor AA
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Cat.#:Pdgfa-304MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa
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Cat.#:Pdgfa-564MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa protein, His-tagged
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Cat.#:Pdgfa&Pdgfb-216RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa&Pdgfb
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Cat.#:Pdgfa-176RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein, His/S-tagged
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Cat.#:Pdgfa-215RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa
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Cat.#:Pdgfa-2732RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein, His & T7-tagged
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Cat.#:PDGFA-4337RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDGFA Protein
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Cat.#:PDGFA-1044CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine PDGFA Protein, Fc-tagged
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Cat.#:PDGFA-5879CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFA
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Cat.#:PDGFA-101HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-3337HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFA 293 Cell Lysate
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Involved Pathway

Pdgfa involved in several pathways and played different roles in them. We selected most pathways Pdgfa participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pdgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
LRRK2; TGFBR2; RPS6KA6; FGF13A; PPP3CCB; IL1B; MECOM; CACNG6A; DUSP8A; TP53
Ras signaling pathway
PRKACB; LOC608458; PLCG1; AKT1; ARF6; PLA2G2F; PAK1; GNB4; FGF7; PIK3R2
Rap signaling pathway
HGF; RAC2; CALM3; LPAR3; FGFR4; LAT; FIGF; ANGPT1; NGF; ACTB
Cytokine-cytokine receptor interaction
Kitl; OSTN; IL6ST; IFNE; CCR6A; INHBC; IFNA5; FLT1; GH1; CRFB2
Phospholipase D signaling pathway
PLCB1; RALGDS; AGPAT4; RALB; PIK3R3; PIK3CB; PTGFR; RAF1; AVPR1B; GAB2
PIK-Akt signaling pathway
MTCP1; G6PC2; Il2; NOS3; COL6A6; PPP2CB; BCL2; STK11; NGFR; RPS6KB2
Focal adhesion
RHOA; VAV2; ITGB8; COL5A2A; PDGFC; ITGA10; FIGF; ELK1; ZYX; IGF1RB
Gap junction
PRKACA; HTR2CL1; TUBA7L; CDK1; MAP2K2; RAF1B; PDGFRA; TUBA4L; PRKACB; MAPK3
Regulation of actin cytoskeleton
FGF1B; HRAS; FGF7; GNA12; ITGB6; MSN; FN1A; TMSB4Y; ACTN2B; MYL7
HTLV-I infection
WNT10B; IL6; PPP3R2; MAP3K3; Pdgfa&Pdgfb; LTBR; POLD2; NFATC1; CRTC1; CD3E; CD3D
Pathways in cancer
RUNX1; RAF1; MSH3; TGFA; GNA11; BIRC5; RALGDS; CCNA1; ITGA2B; RBX1
Transcriptional misregulation in cancer
IL6; CD14; MLLT3; IL3; REL; HOXA11; ETV1; WHSC1; SS18; TGFBR2
MicroRNAs in cancer
DNMT3A; PDGFRB; EFNA3; SPRY2; RDX; BAK1; APC2; TRP53; SHC4; ABCC1
Glioma
HRAS; RB1; CALM4; MAP2K1; Pdgfa&Pdgfb; MAP2K2; KRAS; PIK3CD; ARAF; PIK3R5
Prostate cancer
CCND1; PIK3R5; CCNE1; NKX3; FOXO1; PIK3CG; KRAS; SMARCD1; PDGFRB; FGFR2
Melanoma
FGF17; PIK3R1; PIK3CG; PDGFA; RB1; PIK3CD; MITF; MDM2; BAD; FGF14
Choline metabolism in cancer
PIK3R5; DGKD; GPCPD1; WAS; RAC1; TSC1; CHKA; SLC22A3; SLC22A2; RAF1

Protein Function

Pdgfa has several biochemical functions, for example, collagen binding, growth factor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pdgfa itself. We selected most functions Pdgfa had, and list some proteins which have the same functions with Pdgfa. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein SPARC; PDGFB; ITGA2; HSD17B12; DDR2; TGFBI; SERPINH1; DCN; SRGN; ITGA10
Function growth factor activity
Related Protein INHBAA; BTC; INHBAB; KLK1B4; JAG1; IL6; GRN; FGF8A; IL8L2; PDGFB
Function platelet-derived growth factor binding
Related Protein COL5A1; COL2A1; PDGFRA; COL3A1; COL4A1; COL1A2; PDGFRB; PDGFA; COL6A1; PDGFB
Function platelet-derived growth factor receptor binding
Related Protein IL1R1; LYN; TYMP; PDGFRA; FIGF; VEGFA; PTPRJ; PTEN; PDGFA; PDGFAA
Function protein binding
Related Protein IFIT1; BLOC1S3; NUP153; PKN1; LIMD2; TPRKB; C9orf100; ACAP1; CCP110; COG2
Function protein heterodimerization activity
Related Protein H2-Q10; KCNN1; HIST1H2AF; NEUROD2; RBP4; TAF12; Itgam&Itgb2; CREB3L3; ZHX2; ALG2
Function protein homodimerization activity
Related Protein NOS2; RRAGA; DMRTC1C2; MIXL1; PEX11A; CBLN1; RPE; GRHPR; TMEM192; NR2F2

Interacting Protein

Pdgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pdgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of Pdgfa.
PDGFRA; PDGFRB; PDGFB

Pdgfa Related Articles

Miro, L; Perez-Bosque, A; et al. Vasopressin regulation of epithelial colonic proliferation and permeability is mediated by pericryptal platelet-derived growth factor A. EXPERIMENTAL PHYSIOLOGY 99:1325-1334(2014).
Miller, JD; Benjamin, JT; et al. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 298:L637-L645(2010).