Active Recombinant Human Platelet-derived Growth Factor AA

• Cat.No.: PDGFA-375H
• Product Overview: Recombinant human Xeno-free PDGFaa is expressed inhuman 293 cellsas a mixture of pro-dimers, pro-mature and mature dimers with an apparent molecular mass of 35 to 45 kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. The cytokine is produced in a human cell expression system with serum free, chemically defined media.
• Activity: 200 to 1000 ng/mL ED50.
• Purity: >95%.
• Endotoxin: Endotoxin-free.
• Purity Confirmation: The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
• Activity Assay: The specific activity was determined by the dose-dependent stimulation of the proliferation of 3T3 cells.
• Pathways: Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Prostate cancer; Regulation of actin cytoskeleton; Hemostasis

Gene Information

• Gene Name: PDGFA platelet-derived growth factor alpha polypeptide [ Homo sapiens ]
• Synonyms: platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGFA; platelet-derived growth factor alpha; PDGF A-chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; PDGF1; PDGF subunit A; Platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide
• Gene ID: 5154
• mRNA Refseq: NM_002607
• Protein Refseq: NP_002598
• MIM: 173430
• UniProt ID: P04085
• Chromosome Location: 7p22
• Function: cell surface binding; collagen binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; contributes_to platelet-derived growth factor receptor binding; platelet-derived growth factor receptor binding; protein heterodimerization activity; protein homodimerization activity