S100A12
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Official Full Name
S100 calcium binding protein A12
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Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. -
Synonyms
S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; Calcitermin; Calcium binding protein in amniotic fluid; Calcium-binding protein in amniotic fluid 1; Calgranulin C; Calgranulin related protein; Calgranulin-C; EN RAGE; EN-RAGE; Extracellular newly identified RAGE binding protein; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; Protein S100 A12; S100 calcium-binding protein A12; S10AC_HUMAN; OTTHUMP00000015332; S100 calcium-binding protein A12 (calgranulin C);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Pig
- Rabbit
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- C
- Myc
- DDK
- Fc
- Flag
- GST
- His
- His (Fc)
- Avi
- His(C
- ter)
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- S100A12 Related Articles
- S100A12 Related Research Area
S100A12 involved in several pathways and played different roles in them. We selected most pathways S100A12 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | CREB1B;JUN;PELI2;MAP3K8;IRAK3;S100A12;DUSP3B;DUSP3;CREB1 |
| Advanced glycosylation endproduct receptor signaling | APPA;LGALS3;SAA1;AGER;DDOST;S100B;S100A12;APPB;ALCAMB |
| Cytosolic sensors of pathogen-associated DNA | IFI16;MB21D1;POLR3F;POLR3C;NLRP4B;POLR3GLA;LRRFIP1;S100A12;NLRP4C |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | APPA;SAA1;ALCAMB;AGER;S100B;APPB;S100A12;DHX9;CHST13 |
| Immune System | SEC23A;TNFRSF13C;LILRB5;CTSK;AP1M2;DDX41;WSB1;TREML2;LRRC41 |
| Innate Immune System | RCA2.1;BAIAP2;HBL3;Txn1;BTR22;ALCAMB;DDX41;SIRPB1;BTR12 |
| MyD88 cascade initiated on plasma membrane | ALCAMB;CHST13;AGER;TNIP2;PELI1;PELI2;DHX9;S100A12;TLR10 |
| MyD88 dependent cascade initiated on endosome | CHST13;S100A12;DHX9;ALCAMB;S100B |
S100A12 has several biochemical functions, for example, RAGE receptor binding, calcium ion binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A12 itself. We selected most functions S100A12 had, and list some proteins which have the same functions with S100A12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RAGE receptor binding | S100A12;S100A4;S100B;S100A9;S100A13;FPR1;HMGB2;S100A7;S100P |
| calcium ion binding | ACTN4;VSNL1;BNIP2;Amy1;JAG2B;CAPN3A;PCDH1GB9;CDH12A;NECAB3 |
| copper ion binding | SOD1;HEPHL1A;COMMD1;COX17;SLC11A2;HIST2H3A;MT3;LOX;PRND |
| protein binding | SLC26A6;S100A7;USP28;ALDOB;HNF1B;MRE11A;VPS4A;MEGF6;NKD1 |
| zinc ion binding | DTX4;TRIM61;ZFP385C;PGLYRP4;TCEA2;KDM1B;ZKSCAN5;NR2F1;FHL3B |
S100A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A12.
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- Q&As
- Reviews
Q&As (7)
Ask a questionS100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.
S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.
S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.
S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.
Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.
S100A12 influences calcium signaling in immune cells, affecting their activation and function.
S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.
Customer Reviews (3)
Write a reviewPrecise protein quantification, fundamental for data accuracy in our experiments.
Timely antibody validation, a valuable asset for our laboratory.
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