s100a12
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  • Official Full Name
  • S100 calcium binding protein A12
  • Background
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
  • Synonyms
  • S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; Calcitermin; Calcium binding protein in amniotic fluid; Calcium-binding protein in amniotic fluid 1; Calgranulin C; Calgranulin related protein; Calgranulin-C; EN RAGE; EN-RAGE; Extracellular newly identified RAGE binding protein; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; Protein S100 A12; S100 calcium-binding protein A12; S10AC_HUMAN; OTTHUMP00000015332; S100 calcium-binding protein A12 (calgranulin C)
Cat.#:S100A12-2002HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100A12 Protein, His-tagged
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Cat.#:S100A12-3096HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100 Calcium Binding Protein A12
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Cat.#:S100A12-204HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human S100A12, Fc-tagged, C13&N15 Labeled
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Cat.#:S100A12-215HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human S100A12, Fc-tagged
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Cat.#:S100A12-2483HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100A12, GST-tagged
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Cat.#:S100A12-30229THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100A12, His-tagged
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Cat.#:S100A12-3721HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S100A12, His-tagged
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Cat.#:S100A12-1480RTag:His/T7
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit S100A12 protein, His & T7-tagged
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Cat.#:S100A12-1478CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle S100A12 protein, His-tagged
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Cat.#:S100A12-1479PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig S100A12 protein, His & T7-tagged
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Cat.#:S100A12-2094HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human S100A12 293 Cell Lysate
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Involved Pathway

S100A12 involved in several pathways and played different roles in them. We selected most pathways S100A12 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
UBE2V1; PELI2; S100B; TIRAP; S100A12; CHUK; DUSP3B; TICAM1; SAA1; SIGIRR
Advanced glycosylation endproduct receptor signaling
ALCAMB; APPB; SAA1; APPA; DDOST; AGER; S100B; S100A12; LGALS3
Cytosolic sensors of pathogen-associated DNA
MB21D1; POLR3GLA; AGER; TRIM56; APPB; S100B; NLRP4C; CRCP; IFI16; RIPK3
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
AGER; S100B; SAA1; S100A12; APPA; APPB; DHX9; ALCAMB; CHST13
Immune System
FBXO27; WASF3; ARIH2; UBR2; KLRB1A; BTR02; CD226; FCN3; ASB2; IL1RN
Innate Immune System
DEFA3; RCA2.1; PANX1; TAX1BP1; SIGIRR; CTSLL; CLEC4A; HBL3; BFB; CLEC4D
MyD88 cascade initiated on plasma membrane
S100B; TLR10; DHX9; PELI3; CHST13; PELI1; TNIP2; PELI2; AGER; DUSP3B
MyD88 dependent cascade initiated on endosome
ALCAMB; DHX9; S100A12; CHST13; S100B

Protein Function

S100A12 has several biochemical functions, for example, RAGE receptor binding, calcium ion binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A12 itself. We selected most functions S100A12 had, and list some proteins which have the same functions with S100A12. You can find most of the proteins on our site.
Function
Related Protein
Function RAGE receptor binding
Related Protein HMGB2; S100A8; S100A13; S100B; S100A7; S100A9; S100A4; FPR1; S100A12; HMGB1
Function calcium ion binding
Related Protein PITPNM2; EFHC2; SLIT3; NELL2; OC90; MATN3; SLC25A25; LTBP2; PROCA; VWCE
Function copper ion binding
Related Protein F5; PAM; MOXD1; ATOX1; LOXL1; CP; LOXL2; DBH; LOXL2A; ATP7A
Function protein binding
Related Protein PSMA5; PTTG1IP; C6; TMBIM6; GFI1; SEMG2; TAF15; NSFL1C; DACT2; DERL2
Function zinc ion binding
Related Protein PAPPA2; ZZEF1; TRAIP; TRIM6; ATRX; TRAF1; CXXC1A; ZNF385B; ABLIM2; TRIM35-1

Interacting Protein

S100A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A12.
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S100A12 Related Articles

Zhan, YC; Zhang, F; et al. Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis. INFLAMMATION 38:290-297(2015).
Ahmed, U; Thornalley, PJ; et al. Possible role of methylglyoxal and glyoxalase in arthritis. BIOCHEMICAL SOCIETY TRANSACTIONS 42:538-542(2014).