tnfrsf1a
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 1A
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta;
Cat.#:TNFRSF1A-152HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A, Fc Chimera
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Cat.#:TNFRSF1A-1577HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A
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Cat.#:TNFRSF1A-1690HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF1A, Fc&His-tagged
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Cat.#:TNFRSF1A-248HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human TNFRSF1A protein
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Cat.#:TNFRSF1A-30481THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A, Fc-tagged
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Cat.#:TNFRSF1A-31571THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1A, His-tagged
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Cat.#:TNFRSF1A-3189HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A, His tagged
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Cat.#:TNFRSF1A-3190HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A Protein, His & Avi-tagged, Biotinylated
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Cat.#:TNFRSF1A-3251HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A, Fc-His tagged
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Cat.#:TNFRSF1A-4172HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Type 1, His Tag
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Cat.#:TNFRSF1A-46HTag:HIgG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF1A protein, hIgG-His-tagged
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Cat.#:TNFRSF1A-592HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1A
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Cat.#:TNFRSF1A-65HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNF-R1, Fc-tagged
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Cat.#:TNFRSF1A-660HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human tumor necrosis factor receptor superfamily, member 1A, His-tagged
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Cat.#:TNFRSF1A-7048HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1A protein, His & GST-tagged
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Cat.#:TNFRSF1A-707HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF1A, Fc-tagged, Biotinylated
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Cat.#:TNFRSF1A-7162HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A, His-tagged
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Cat.#:Tnfrsf1a-1780MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Tnfrsf1a
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Cat.#:Tnfrsf1a-2029MTag:
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf1a protein
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Cat.#:Tnfrsf1a-3306MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf1a, His tagged
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Cat.#:Tnfrsf1a-634MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf1a, Fc tagged
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Cat.#:Tnfrsf1a-7049MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf1a protein, His-tagged
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Cat.#:TNFRSF1A-413RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tnfrsf1a, His tagged
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Cat.#:TNFRSF1A-6197RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFRSF1A Protein
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Cat.#:Tnfrsf1a-7050RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfrsf1a protein, His-tagged
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Cat.#:Tnfrsf1a-7051RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tnfrsf1a protein, His-tagged
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Cat.#:Tnfrsf1a-7449RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Tnfrsf1a, Fc tagged
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Cat.#:TNFRSF1A-2478CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFRSF1A
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Cat.#:TNFRSF1A-12401ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TNFRSF1A
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Cat.#:TNFRSF1A-1908HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF1A, Fc-His
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Cat.#:TNFRSF1A-2390HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF1A cell lysate
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Cat.#:TNFRSF1A-1693MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFRSF1A cell lysate
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Cat.#:TNFRSF1A-1084RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat TNFRSF1A cell lysate
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Cat.#:TNFR-P002HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human TNFRSF1A, Fc-tagged therapeutic protein
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Cat.#:TNFRSF1A-P013HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF1A, Fc-tagged therapeutic protein
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Cat.#:TNFRSF1A-P017HTag:
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF1A therapeutic protein
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Cat.#:TNFRSF1A-P018HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF1A therapeutic protein
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Involved Pathway

TNFRSF1A involved in several pathways and played different roles in them. We selected most pathways TNFRSF1A participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TRAF2; RASGRF2B; CACNG1A; PAK2A; ARR3A; FASLG; NLK1; MAP2K4; RPS6KA4; PLA2G4C
Cytokine-cytokine receptor interaction
CCL13; TNFSF18; TNFRSF19; TNFRSF18; KDR; TNFSF4; Flt3l; IL25; CCL7; AMH
NF-kappa B signaling pathway
CD40; SYK; TRADD; TNFSF13B; NFKBIA; LTA; TRAF2; NFKB1; TNF; CXCL2
Sphingolipid signaling pathway
LASS1; NFKB1; ABCC1; PRKCZ; GNAI3; MAPK10; SPTLC2; OPRD1; ASAH2; LASS4
Apoptosis
BIRC2; SPNA2; RIPK1; RNF8; CAPN1B; FASLG; GZMC; CLSPN; FADD; IRAK4
Osteoclast differentiation
IKBKB; FCGR1A; CYBA; RAC1; PIK3R5; LCK; LILRA2; FOS; TRAF2; TGFB1
TNF signaling pathway
MAP2K6; MLKL; LTA; VEGFC; SOCS3; RPS6KA5; FADD; IL1B; TRADD; CXCL2
Adipocytokine signaling pathway
NFKBIAB; RXRA; PRKAG2A; PRKAG3B; IRS2; CD36; TRAF2; PTPN11B; ACSL5; PRKAG3
Insulin resistance
G6PCA.2; INSRA; PPP1R3CB; PRKAG3B; TNFRSF1A; G6PCA.1; PPP1CAA; PPP1CAB; MAPK8B; CD36
Non-alcoholic fatty liver disease (NAFLD)
FAS; PIK3R3; ITCH; NDUFS4; CYCS; PRKAG3; ADIPOR1; BID; INS; NDUFA7
Alzheimers disease
PSEN1; PPP3CA; Casp3; CALM3; NDUFA9; UQCRC2; APOE; NDUFS2; NDUFS1; CDK5R1
Amyotrophic lateral sclerosis (ALS)
TP53; GRIN2B; NEFM; CCS; TRP53; MAPK14; TNF; PPP3R1; CASP1; MAPK13
Chagas disease (American trypanosomiasis)
CXCL8; CD247; C1QB; IFNB1; MAPK9; PPP2R2A; CD3E; PPP2R2D; GNAI3; PPP2R1A
Toxoplasmosis
PIK3CA; LAMC2; LAMB4; HLA-DOA; IL12B; LAMB2; BIRC7; HLA-DRB1; TGFB3; ITGA6
Tuberculosis
ATP6V0A4; IL12B; CYCS; IFNA12; ATP6V0B; LBP; FCER1G; Cd209g; TLR9; NFYC
Hepatitis C
IFN-a; NFKB1; NFKBIA; IRF9; OAS1A; DDX58; EIF2AK3; PDPK1; TRP53; RNASEL
Influenza A
IFNA13; HNRNPUL1; CASP1; NXF3; IL33; TNFRSF10D; NXT2; TNFSF10; ACTB; ACTG1
HTLV-I infection
PCNA; ZFP36; CD3E; SMAD4; TGFBR2; HLA-C; WNT2B; HLA-DPA1; MYBL2; IL15RA
Herpes simplex infection
OAS1; MAPK10; STAT1A; SRSF2A; THOC4; NFKBIB; HNRNPK; PER1A; C3; SRSF9

Protein Function

TNFRSF1A has several biochemical functions, for example, protein binding, tumor necrosis factor binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1A itself. We selected most functions TNFRSF1A had, and list some proteins which have the same functions with TNFRSF1A. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein RBMY1B; CTCF; Ntng2; GATAD2A; APBA2; DNMT3L; ABI2; CNTF; ANXA9; USP17L2
Function tumor necrosis factor binding
Related Protein Tnfrsf26; A2M; TNFRSF1A
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF8; EDA2R; TNFRSF11B; RELT; Tnfrsf26; TNFRSFA; TNFRSF21; TNFRSF10B; TNFRSF10C; TNFRSF19

Interacting Protein

TNFRSF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1A.
TRADD; TNF

TNFRSF1A Related Articles

Cantarini, L; Lopalco, G; et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. AUTOIMMUNITY REVIEWS 14:90-97(2015).
Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).

TNFRSF1A Related Gene Family

TNF Cytokines