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tumor necrosis factor receptor superfamily, member 1A
Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Synonyms
TNFRSF1A;tumor necrosis factor receptor superfamily, member 1A;FPF;MS5;p55;p60;TBP1;TNF-R;TNFAR;TNFR1;p55-R;CD120a;TNFR55;TNFR60;TNF-R-I;TNF-R55;TNFR1-d2;tumor necrosis factor receptor superfamily member 1A;TNF-R1;TNF-RI;TNFR-I;tumor necrosis factor-alpha receptor;tumor necrosis factor receptor type 1;tumor necrosis factor binding protein 1;tumor necrosis factor receptor 1A isoform beta
TNFRSF1A involved in several pathways and played different roles in them. We selected most pathways TNFRSF1A participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein Function
TNFRSF1A has several biochemical functions, for example, protein binding,tumor necrosis factor binding,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1A itself. We selected most functions TNFRSF1A had, and list some proteins which have the same functions with TNFRSF1A. You can find most of the proteins on our site.
Function
Related Protein
Interacting Protein
TNFRSF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1A.
Cantarini, L; Lopalco, G; et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. AUTOIMMUNITY REVIEWS 14:90-97(2015).
Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
