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Official Full Name tumor necrosis factor receptor superfamily, member 1A
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Synonyms TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • His
    • Avi
    • GST
    • HIgG
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Tnfrsf1a-141M Recombinant Mouse Tnfrsf1a Protein E.coli
    Human TNFR-P002H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein CHO Fc
    Human TNFRSF1A-152H Recombinant Human TNFRSF1A, Fc Chimera HEK293 Fc
    Human TNFRSF1A-1577H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A Sf9 Insect Cell N/A
    Human TNFRSF1A-1690H Recombinant Human TNFRSF1A, Fc&His-tagged NS0 Fc/His
    Human TNFRSF1A-1908H Recombinant Human TNFRSF1A, Fc-His NSO Fc
    Human TNFRSF1A-2390HCL Recombinant Human TNFRSF1A cell lysate Human Cell N/A
    Human TNFRSF1A-248H Recombinant Human TNFRSF1A protein E.coli N/A
    Human TNFRSF1A-30481TH Recombinant Human TNFRSF1A, Fc-tagged HEK293 Fc
    Human TNFRSF1A-31571TH Recombinant Human TNFRSF1A, His-tagged E.coli His
    Human TNFRSF1A-3189H Recombinant Human TNFRSF1A, His tagged Human Cell His
    Human TNFRSF1A-3190H Recombinant Human TNFRSF1A Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNFRSF1A-3251H Recombinant Human TNFRSF1A, Fc-His tagged Human Cell Fc/His
    Human TNFRSF1A-4172H Recombinant Human Tumor Necrosis Factor Receptor Type 1, His Tag Human His
    Human TNFRSF1A-46H Recombinant Human TNFRSF1A protein, hIgG-His-tagged Insect Cell His/HIgG
    Human TNFRSF1A-592H Recombinant Human TNFRSF1A E.coli N/A
    Human TNFRSF1A-65H Recombinant Human TNF-R1, Fc-tagged HEK293 Fc
    Human TNFRSF1A-660H Recombinant Human tumor necrosis factor receptor superfamily, member 1A, His-tagged E.coli His
    Human TNFRSF1A-7048H Recombinant Human TNFRSF1A protein, His & GST-tagged E.coli His/GST
    Human TNFRSF1A-707H Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF1A-7162H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A, His-tagged E.coli His
    Human TNFRSF1A-P013H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein Fc
    Human TNFRSF1A-P017H Recombinant Human TNFRSF1A therapeutic protein N/A
    Human TNFRSF1A-P018H Recombinant Human TNFRSF1A therapeutic protein E.coli N/A
    Mouse TNFRSF1A-1693MCL Recombinant Mouse TNFRSF1A cell lysate Human Cell N/A
    Mouse Tnfrsf1a-1780M Recombinant Mouse Tnfrsf1a NSO N/A
    Mouse Tnfrsf1a-2029M Recombinant Mouse Tnfrsf1a protein E.coli N/A
    Mouse Tnfrsf1a-3306M Recombinant Mouse Tnfrsf1a, His tagged Human Cell His
    Mouse Tnfrsf1a-634M Recombinant Mouse Tnfrsf1a, Fc tagged Human Cell Fc
    Mouse Tnfrsf1a-7049M Recombinant Mouse Tnfrsf1a protein, His-tagged E.coli His
    Rat TNFRSF1A-1084RCL Recombinant Rat TNFRSF1A cell lysate Human Cell N/A
    Rat TNFRSF1A-413R Recombinant Rat Tnfrsf1a, His tagged Human Cell His
    Rat TNFRSF1A-6197R Recombinant Rat TNFRSF1A Protein Mammalian Cell His
    Rat Tnfrsf1a-7050R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His
    Rat Tnfrsf1a-7051R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His
    Rat Tnfrsf1a-7449R Recombinant Rat Tnfrsf1a, Fc tagged Human Cell Fc
    Chicken TNFRSF1A-2478C Recombinant Chicken TNFRSF1A Mammalian Cell His
    Zebrafish TNFRSF1A-12401Z Recombinant Zebrafish TNFRSF1A Mammalian Cell His

    TNFRSF1A involved in several pathways and played different roles in them. We selected most pathways TNFRSF1A participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF1B; RASGRF2; MAP3K13; CACNG7; PPM1BB; CASP3A; MAP3K1; MAP2K2B; PRKACBB; TGFB3
    Cytokine-cytokine receptor interaction CXCL5; IL10RA; BMPR1AA; KDRL; IFNPHI3; ACVR1B; TNFRSF10C; CCL19B; IL5RA; IL1R2
    NF-kappa B signaling pathway TNFSF14; UBE2I; TNFRSF11A; TNFSF13B; CXCL2; CCL21; BIRC2; ATM; NFKB1; RELA
    Sphingolipid signaling pathway PPP2R5B; PLCB1; LASS5; LASS4; PPP2CA; PPP2R1B; NOS3; ASAH1; PRKCZ; PPP2R5C
    Osteoclast differentiation CYBB; FOSB; FYN; PPP3CB; NOX3; SIRPB1; MAPK11; NCF4; PIK3CA; IL1A
    TNF signaling pathway MAP3K14; MAPK13; ATF4; FOS; LIF; IKBKB; TRADD; MLKL; NFKB1; MMP3
    Adipocytokine signaling pathway ADIPOR2; ACSL4A; IKBKG; RXRG; RELA; ACSBG2; MTOR; PRKAB2; PRKAG1; AKT2
    Insulin resistance RELA; PYGB; MGEA5; PTENB; MAPK8; STAT3; G6PC; PPARAB; PPP2R4; NFKBIA
    Non-alcoholic fatty liver disease (NAFLD) NDUFB11; NR1H3; NDUFB8; IL6; PPARA; NDUFA11; MAPK10; MAP3K11; PRKAB1; COX6B2
    Alzheimers disease COX8C; LRP1; GSK3B; NDUFV3; NDUFA10; NDUFC2; APOE; HSD17B10; CAPN1; APBB1
    Amyotrophic lateral sclerosis (ALS) CAT; BAX; CASP1; GRIA2; TRP53; APAF1; MAPK14; GRIN2A; TOMM40; GRIN2B
    Chagas disease (American trypanosomiasis) ACE; CD247; NFKB1; NFKBIA; MAPK8; MAPK11; SMAD2; NOS2; PPP2R1B; IRAK1
    Toxoplasmosis MAP3K7; TRAF6; MAPK12; HLA-DRB1; TLR2; PDPK1; TGFB1; Toxoplasma Gondii Microneme Protein MIC3; HLA-DOB; HLA-DRB4
    Tuberculosis CALM3; LBP; TNF; STAT1; IFNA5; TRAF6; IL12A; MRC1; CASP9; CLEC4E
    Hepatitis C STAT2; RIPK1; IRF3; IFNA16; EIF2AK2; IKBKB; PIK3CB; PPP2R1B; Ifna11; SOCS3
    HTLV-I infection POLD4; WNT2; MSX1; DVL3; MYB; VAC14; WNT8B; PPP3R2; PIK3R3; XIAP
    Herpes simplex infection ARNTL1B; HLA-G; HLA-DQA2; IKBKG; TLR2; TAB2; CD74; HLA-DQA1; PER1A; UBE2R2

    TNFRSF1A has several biochemical functions, for example, protein binding, tumor necrosis factor binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1A itself. We selected most functions TNFRSF1A had, and list some proteins which have the same functions with TNFRSF1A. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TSSK3; CP110; PSMB7; NME3; KRAS; ACTA1; ZFAND5; LARP4B; CA1; PARP4
    tumor necrosis factor binding A2M; Tnfrsf26; TNFRSF1A
    tumor necrosis factor-activated receptor activity TNFRSF18; TNFRSF8; TNFRSF19; HDR; TNFRSF14; TNFRSF1B; TNFRSF11A; TNFRSF10C; TNFRSFA; NRADD

    TNFRSF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1A.


    Cantarini, L; Lopalco, G; et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. AUTOIMMUNITY REVIEWS 14:90-97(2015).
    Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).

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