Tnfrsf10b
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Official Full Name
tumor necrosis factor receptor superfamily, member 10b
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Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] -
Synonyms
TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Cynomolgus
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus monkey
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Avi
- His
- C
- Fc
- hFc
- mFc
- Fc|His
- hIgG1
- hIgG4
- His|Avi
- His|GST
- HlgG1 Fc
- human|IgG1|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- Tnfrsf10b Related Articles
- Tnfrsf10b Related Gene Family
- Tnfrsf10b Related Research Area
- Tnfrsf10b Related Signal Pathway
Tnfrsf10b involved in several pathways and played different roles in them. We selected most pathways Tnfrsf10b participated on our site, such as Cytokine-cytokine receptor interaction, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf10b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CXCR6;CXCL12A;IFNK;CXCR5;LEPR;IL3RA;IL17RA;EDA2R;BMP7 |
p signaling pathway | CCND3;RRM2;CCNE1;GADD45B;Casp3;CYCSB;SHISA5;CCND2;BAI1 |
Apoptosis | FASLG;TRAF2;CASP8L1;CASP3A;CAPN1;DIABLO;MYD88;DNM1L;PIK3CG |
Natural killer cell mediated cytotoxicity | HLA-E;SH2D1B;KIR2DL1;RAET1L;GZMB;PRKCA;ARAF;RAET1E;NCR2 |
Measles | MX1;EIF2AK4;IL1B;IRF3;PIK3R5;TNFRSF10A;DDX58;CD3E; CD3D;MAVS |
Influenza A | PYCARD;TYK2;MAPK1;HSPA2;KPNA1;BMA1;IFNA14;CASP1;HLA-DRB1 |
Tnfrsf10b has several biochemical functions, for example, TRAIL binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf10b itself. We selected most functions Tnfrsf10b had, and list some proteins which have the same functions with Tnfrsf10b. You can find most of the proteins on our site.
Function | Related Protein |
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TRAIL binding | Tnfrsf22;TNFRSF10B;TNFRSF10C;TNFRSF10A;TNFRSF10D |
protein binding | SPTLC1;OAZ2;LAT;COPG;FRMD4B;KPNA6;WHSC1L1;ANKS4B;DOK4 |
receptor activity | NRXN1;CADM2A;CADM3;CADM1;GABRA5;STRA6;ANTXRL;F2RL1.2;CUL5 |
tumor necrosis factor-activated receptor activity | CD27;TNFRSFA;TNFRSF25;TNFRSF10C;TNFRSF1A;TNFRSF9;EDA2R;TNFRSF10D;RELT |
Tnfrsf10b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf10b here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf10b.
TNFSF10
- Q&As
- Reviews
Q&As (5)
Ask a questionActivation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.
TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.
TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.
TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.
Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.
Customer Reviews (3)
Write a reviewThe combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.
The manufacturer's commitment to providing excellent technical support is highly valuable.
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