tnfrsf10b
Share
  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 10b
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);
Cat.#:TNFRSF10B-599HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B Protein, His-Avi-tagged, Biotinylated
+Inquiry
Cat.#:TNFRSF10B-1999HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B Protein, MYC/DDK-tagged
+Inquiry
Cat.#:TNFRSF10B-2350HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B, His tagged
+Inquiry
Cat.#:TNFRSF10B-27023THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B, Fc-tagged
+Inquiry
Cat.#:TNFRSF10B-28127THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF10B, Fc-tagged
+Inquiry
Cat.#:TNFRSF10B-28129THTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B, Fc-tagged
+Inquiry
Cat.#:TNFRSF10B-28130THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF10B, Fc-tagged
+Inquiry
Cat.#:TNFRSF10B-309HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B Protein, His-tagged
+Inquiry
Cat.#:TNFRSF10B-310HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B Protein, Fc/His-tagged
+Inquiry
Cat.#:TNFRSF10B-311HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10B Protein
+Inquiry
Cat.#:TNFRSF10B-518HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10B
+Inquiry
Cat.#:TNFRSF10B-51HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRAIL-R2, Fc Chimera
+Inquiry
Cat.#:TNFRSF10B-56HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled
+Inquiry
Cat.#:TNFRSF10B-598HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF10B, Fc-tagged, Biotinylated
+Inquiry
Cat.#:TNFRSF10B-7761HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF10B protein, His & GST-tagged
+Inquiry
Cat.#:TNFRSF10B-884HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B, Fc-His tagged
+Inquiry
Cat.#:Tnfrsf10b-3292MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf10b, His tagged
+Inquiry
Cat.#:Tnfrsf10b-3321MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf10b, Fc-His tagged
+Inquiry
Cat.#:Tnfrsf10b-7762MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf10b protein, His-tagged
+Inquiry
Cat.#:Tnfrsf10b-7763MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf10b protein, His-tagged
+Inquiry
Cat.#:TNFRSF10B-1637RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF10B Protein
+Inquiry
Cat.#:TNFRSF10B-1638RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF10B Protein, hIgG1-tagged
+Inquiry
Cat.#:TNFRSF10B-1639RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF10B Protein, hIgG4-tagged
+Inquiry
Cat.#:TNFRSF10B-5691CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFRSF10B
+Inquiry
Cat.#:TNFRSF10B-460HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B, Fc Chimera
+Inquiry
Cat.#:Tnfrsf10b-178MTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf10b
+Inquiry
Cat.#:TNFRSF10B-2829HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF10B cell lysate
+Inquiry
Cat.#:TNFRSF10B-2397MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse TNFRSF10B cell lysate
+Inquiry
Cat.#:CSC-P0185Tag:
Source (Host):Species:
Product nameAnti-Human DR5 MAb Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0186Tag:
Source (Host):Species:
Product nameAnti-Human DR5 F(ab) Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0187Tag:
Source (Host):Species:
Product nameAnti-Human DR5 scFv Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0380Tag:
Source (Host):Species:
Product nameAnti-Human DR5 MAb Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0381Tag:
Source (Host):Species:
Product nameAnti-Human DR5 F(ab) Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0382Tag:
Source (Host):Species:
Product nameAnti-Human DR5 scFv Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0392Tag:
Source (Host):Species:
Product nameAnti-Human TRAIL-R2 MAb Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0393Tag:
Source (Host):Species:
Product nameAnti-Human TRAIL-R2 F(ab) Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0394Tag:
Source (Host):Species:
Product nameAnti-Human TRAIL-R2 scFv Stable Cell Line-CHO
+Inquiry

Involved Pathway

Tnfrsf10b involved in several pathways and played different roles in them. We selected most pathways Tnfrsf10b participated on our site, such as Cytokine-cytokine receptor interaction, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf10b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNA3; TGFBR1; TNFSF18; IFNA16; CXCL16; CCL4; IL13RA1; IL6R; IRX1; CXCR2
p signaling pathway
BIDA; PPM1DA; CASP3B; CYCSB; SIAH1; TSC2; IGFBP3; SIAH1A; CCNG1; ATM
Apoptosis
CFLAR; RIPK1L; STK24; HIST1H1B; NFKBIAA; BIRC2; PRKAR1A; BADB; FADD; DIABLOA
Natural killer cell mediated cytotoxicity
LCP2; MAP2K1; PTK2B; ZAP70; PIK3CB; IFNA4; HRAS; ICAM1; IFNA6; Raet1a
Measles
MYD88; TNFRSF10D; OAS1B; PIK3R1; CD3G; TP53; IL2RG; NFKBIA; RCHY1; IFNA16
Influenza A
PIK3CG; PRSS2; TLR7; ADAR; HLA-DQA2; IVNS1ABP; PABPN1L; PRKCB; STAT2; BLA

Protein Function

Tnfrsf10b has several biochemical functions, for example, TRAIL binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf10b itself. We selected most functions Tnfrsf10b had, and list some proteins which have the same functions with Tnfrsf10b. You can find most of the proteins on our site.
Function
Related Protein
Function TRAIL binding
Related Protein TNFRSF10C; TNFRSF10A; TNFRSF10B; TNFRSF10D; Tnfrsf22
Function protein binding
Related Protein HRAS; SPOPL; MMP9; C12orf68; PDCD1; KRT2; PSMA4; TMEM123; NAA50; RBP5
Function receptor activity
Related Protein DARC; TNFRSF17; IL18RAP; ADIPOR1B; SEC63; RPA1; TLR1; SMAGP; TNFRSF11B; RNF139
Function tumor necrosis factor-activated receptor activity
Related Protein NRADD; TNFRSF25; TNFRSF8; FAS; TNFRSF14; TNFRSF10D; RELT; NGFRB; TNFRSF1B; TNFRSF19

Interacting Protein

Tnfrsf10b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf10b here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf10b.
TNFSF10

Tnfrsf10b Related Articles

Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).
Seirafian, S; Prod'homme, V; et al. Human cytomegalovirus suppresses Fas expression and function. JOURNAL OF GENERAL VIROLOGY 95:933-939(2014).

Tnfrsf10b Related Gene Family

TNF