vwf
Share
  • Official Full Name
  • von Willebrand factor
  • Background
  • The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrands disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
  • Synonyms
  • VWF; von Willebrand factor; VWD; F8VWF; coagulation factor VIII VWF;
Cat.#:VWF-2643MTag:His|Myc
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse VWF Protein (1498-1665 aa), His-Myc-tagged
+Inquiry
Cat.#:VWF-126HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Von Willebrand Factor
+Inquiry
Cat.#:VWF-2712HTag:Met|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human VWF protein, Met/His-tagged
+Inquiry
Cat.#:VWF-2713HTag:DDK
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human VWF, DDK-tagged
+Inquiry
Cat.#:VWF-2714HTag:DDK
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human VWF, DDK-tagged
+Inquiry
Cat.#:VWF-894HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human VWF, His tagged
+Inquiry
Cat.#:Vwf-1432MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Vwf protein, His-tagged
+Inquiry
Cat.#:VWF-18420MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse VWF Protein
+Inquiry
Cat.#:Vwf-7788RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Vwf protein, His-tagged
+Inquiry
Cat.#:Vwf-7789RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Vwf protein, His-tagged
+Inquiry
Cat.#:VWF-5183RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey VWF Protein, His-tagged
+Inquiry
Cat.#:VWF-4940DTag:His
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog VWF protein, His-tagged
+Inquiry
Cat.#:VWF-8353ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish VWF
+Inquiry
Cat.#:VWF-4903PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig VWF protein, His-tagged
+Inquiry
Cat.#:VWF-17HTag:N/A
Source (Host):Species:Human
Product nameNative Human von Willebrand Factor, Factor VIII Free
+Inquiry
Cat.#:VWF-369HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Von Willebrand Factor
+Inquiry
Cat.#:VWF-001HCLTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human VWF cell lysate
+Inquiry
Cat.#:VWF-30HTag:N/A
Source (Host):Species:Human
Product nameVWF Factor Reference standard
+Inquiry

Involved Pathway

vWF involved in several pathways and played different roles in them. We selected most pathways vWF participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with vWF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
MTOR; TCL1B4; COL4A1; CREB3L3; FGF22; PPP2R5A; IKBKB; THBS1; COL6A6; NOS3
Focal adhesion
LAMA5; LAMA3; LAMB4; ITGB3B; RAPGEF1; PPP1CA; IGF1RB; COL6A6; RAC1B; COL5A1
ECM-receptor interaction
SV2C; COL1A1; ITGB7; TNC; ITGA6; TNW; IBSP; Npnt; ITGA9; ITGA11A
Complement and coagulation cascades
F12; F9; C7; C4BPA; F8; SERPIND1; PLAT; SERPINC1; Serpina1c; VWF
Platelet activation
F2RL3; ROCK1; ROCK2; LYN; PTGS1; GUCY1B3; LCP2; P2RY1; BTK; ARHGEF1

Protein Function

vWF has several biochemical functions, for example, chaperone binding, collagen binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by vWF itself. We selected most functions vWF had, and list some proteins which have the same functions with vWF. You can find most of the proteins on our site.
Function
Related Protein
Function chaperone binding
Related Protein SDF2L1; TIMM44; AHSA2; CDKN1B; TRP53; UBL4A; DNAJB4; SYVN1; TG; PFDN4
Function collagen binding
Related Protein ITGA2; CTSL1; VWF; MTAP1A; ACHE; CD44; SERPINH1B; COMP; DDR2; ABI3BP
Function glycoprotein binding
Related Protein CSNK1D; AZGP1; FBXO6; LDLR; CDH1; TGFB1; SHB; BBC3; ITGB2; TFR2
Function identical protein binding
Related Protein SH3GL2; PRC1; USP4; IAPP; SIAH1; TRP53; HOMER1; TYROBP; PACSIN2; LRRK1
Function immunoglobulin binding
Related Protein cgr2b; HRG; VWF
Function integrin binding
Related Protein ICAM3; CYR61; WISP1A; CD226; ITGA6; S1PR2; ADAM15; TIMP2; TGFBI; WISP2
Function protease binding
Related Protein BDKRB2; BRCA2; LCN2; TYSND1; FLOT2; THAP5; NFRKB; SERPINF2; TIMP2A; CAST
Function protein N-terminus binding
Related Protein RND2; NCOA3; RBPJ; PDLIM5; SMARCC1; PEX5; ERCC5; SNCA; PDCD10; NIPBL
Function protein binding
Related Protein SMCP; TOMM70A; CALM3; PDXP; FBXO27; MAGEE1; H2-KE2; LIMK2; RXFP1; CDC42EP5
Function protein homodimerization activity
Related Protein ALDH5A1; TPD52L1; TGFB1; CCBL2; HLCS; TERFA; DGAT2; ABCD3; MASP1; WWTR1

Interacting Protein

vWF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with vWF here. Most of them are supplied by our site. Hope this information will be useful for your research of vWF.
GP1BA; ADAMTS13

vWF Related Articles

Timm, A; Hillarp, A; et al. Comparison of automated von Willebrand factor activity assays. THROMBOSIS RESEARCH 135:684-691(2015).
Tomlinson, RE; Silva, MJ; et al. HIF-1 alpha regulates bone formation after osteogenic mechanical loading. BONE 73:98-104(2015).