Recombinant Full Length Human VWF Protein, C-His-tagged

• Cat.No.: VWF-12HFL
• Product Overview: Purified recombinant protein of Human von Willebrand factor (VWF), Ala23-End, with C-terminal His tag, secretory expressed in HEK293 cells.

Specification

• Description: This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.
• Source: HEK293
• Species: Human
• Tag: His
• Form: PBS, pH 7.4, 10% glycerol.
• Molecular Mass: 308.3 kDa
• AA Sequence: A DNA sequence from TrueORF clone, RC218497, encoding the region(Ala23-End) of VWF.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, ECM-receptor interaction, Focal adhesion

Gene Information

• Gene Name: VWF von Willebrand factor [ Homo sapiens (human) ]
• Official Symbol: VWF
• Synonyms: VWD; F8VWF
• Gene ID: 7450
• mRNA Refseq: NM_000552.5
• Protein Refseq: NP_000543.3
• MIM: 613160
• UniProt ID: P04275