ARG1 Protein


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Official Full Name arginase 1
Background Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Synonyms ARG1; arginase 1; arginase-1; arginase, liver; type I arginase; liver-type arginase;
    • Species :
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Rat Liver
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • His-SUMO
    • MYC/DDK
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ARG1-2489H Recombinant Human Arginase, Liver, His-tagged E.coli His
    Human ARG1-28658TH Recombinant Human ARG1, His-tagged E.coli His
    Human ARG1-3913H Recombinant Human ARG1 protein, His-tagged HEK293 His
    Human ARG1-594H Recombinant Human Arginase, Liver E.coli N/A
    Human ARG1-756H Recombinant Human ARG1 protein, GST-tagged Wheat Germ GST
    Human ARG1-9810H Recombinant Human ARG1, His-tagged E.coli His
    Mouse Arg1-1132M Recombinant Mouse Arg1 Protein, His-tagged Yeast His
    Mouse Arg1-1523M Recombinant Mouse Arg1 protein, His-tagged E.coli His
    Rat Arg1-1524R Recombinant Rat Arg1 protein, His-tagged E.coli His
    Rat Arg1-3622R Recombinant Rat Arg1, His-tagged E.Coli or Yeast His
    Zebrafish ARG1-4221Z Recombinant Zebrafish ARG1 Mammalian Cell His
    Human ARG1-1869HCL Recombinant Human ARG1 cell lysate Human Cell N/A
    Human ARG1-012H Recombinant Human ARG1 Protein, His-tagged HEK293 His
    Rabbit ARG1-243R Recombinant Rabbit ARG1 Protein, His-tagged E.coli N-His
    Human ARG1-2546H Recombinant Human ARG1 protein, GST-tagged E.coli GST
    Mouse Arg1-4538M Recombinant Mouse Arg1 protein, His-SUMO-tagged E.coli His-SUMO
    Human ARG1-2582H Recombinant Human ARG1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ARG1-2961H Recombinant Human ARG1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ARG1-296H Recombinant Human ARG1 Protein, His/MYC-tagged HEK293 His/Myc
    Mouse Arg1-639M Recombinant Mouse Arg1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat Arg1-150R Native Rat Arginase Rat Liver N/A
    Rat Arg1-8044R Native Rat Liver Arginase Rat Liver N/A

    ARG1 involved in several pathways and played different roles in them. We selected most pathways ARG1 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine biosynthesis GLUD1B; NOS2B; GOT2B; NOS2A; GPT; OTC; GLULB; ACY1; ASL; GPT2L
    Arginine and proline metabolism OAT; AZIN2; ALDH1B1; LAP3; SAT2B; SAT1A.2; CKMT1A; NOS2B; DAO.3; ODC1
    Metabolic pathways ALG6; PFKM; PIP5K1A; CYP4A10; GPIB; NME2B.1; ASL; LSM1; QRSL1; SAT1A.2
    Biosynthesis of amino acids ASL; TAT; PYCRL; PFKP; ALDOAA; ASL2; ARG2; PKLR; THA1; PRPS1B
    Amoebiasis RAB5C; IL1R2; PTK2; PLCB4; PRKCB; PIK3CG; IL12A; GNA14; CXCL1; TLR2

    ARG1 has several biochemical functions, for example, arginase activity, manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARG1 itself. We selected most functions ARG1 had, and list some proteins which have the same functions with ARG1. You can find most of the proteins on our site.

    Function Related Protein
    arginase activity ARG1; ARG2
    manganese ion binding PAPOLA; WRN; SOD2; PRIMPOL; GALNT1; PPM1AB; HMGCL; GALNT2; PPM1A; PEPD

    ARG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARG1.

    abh; bec; ESR1; FLOT1; USP53; ATG101; ALDH4A1; midostaurin; GABARAP; MYC; GABARAPL2

    Wang, JH; Zhao, DM; et al. Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype. JOURNAL OF MOLECULAR NEUROSCIENCE 55:880-890(2015).
    Bieren, JEV; Volpe, B; et al. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I. JOURNAL OF IMMUNOLOGY 194:1154-1163(2015).

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