ARG1
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Official Full Name
arginase 1 -
Overview
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
ARG1;arginase 1;arginase-1;arginase, liver;type I arginase;liver-type arginase
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Rabbit
- Vigna radiata var. radiata (Mung bean) (Phaseolus aureus)
- HEK293
- E.coli
- Rat Liver
- Yeast
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- His
- Non
- GST
- Flag
- DDK
- Myc
- Avi
- Fc
- SUMO
Involved Pathway
ARG1 involved in several pathways and played different roles in them. We selected most pathways ARG1 participated on our site, such as Arginine biosynthesis,Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALG1,PNLIP,HMGCLL1,CYP4F18,PKM,AGPAT4,RRM2B,BPGM,PYCRL,COX8C |
| Amoebiasis | VCL,LAMA3,COL5A1,ACTN2,COL4A4,CSF2,FN1,LAMC3,SERPINB13,ITGB2 |
| Arginine biosynthesis | GPT2L,NOS3,GOT2B,ybaS,GOT2A,CPS1,NOS2,GLULC,GLULA,GOT2 |
| Biosynthesis of amino acids | PSPH,GPT2,NAGS,TKTL2,CS,GOT2A,ALDH18A1,PGK1,PCXB,ASS1 |
| Arginine and proline metabolism | CNDP2,CKMT2B,CARNS1,GOT2B,CKMA,SAT2B,ALDH3A2A,SAT2,AMD1,NOS1 |
Protein Function
ARG1 has several biochemical functions, for example, arginase activity,manganese ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARG1 itself. We selected most functions ARG1 had, and list some proteins which have the same functions with ARG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arginase activity | ARG2 |
| manganese ion binding | PPM1N,PPEF1,NUDT7,B4GALT7,ME1,PPM1M,PPM1AB,SOD2,MPPE1,GALNT1 |
Interacting Protein
ARG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARG1.
abh;bec;ESR1;FLOT1;USP53;ATG101;ALDH4A1;midostaurin;GABARAP;MYC;GABARAPL2
Resources
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References
- Wang, JH; Zhao, DM; et al. Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype. JOURNAL OF MOLECULAR NEUROSCIENCE 55:880-890(2015).
- Bieren, JEV; Volpe, B; et al. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I. JOURNAL OF IMMUNOLOGY 194:1154-1163(2015).
