Recombinant Human CASP1 Protein, His-tagged
Cat.No. : | CASP1-173H |
Product Overview : | Recombinant Human CASP1, transcript variant alpha, fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 50mM Tris, 8M Urea, pH8.0. |
Molecular Mass : | 45 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | CASP1 caspase 1, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Official Symbol : | CASP1 |
Synonyms : | CASP1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis related cysteine peptidase (interleukin 1, beta, convertase) , caspase 1, apoptosis related cysteine protease (interleukin 1, beta, convertase) , IL1BC; caspase-1; caspase 1; ICE; interleukin 1; beta; convertase; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); P45; IL1BC; |
Gene ID : | 834 |
mRNA Refseq : | NM_001223 |
Protein Refseq : | NP_150634 |
MIM : | 147678 |
UniProt ID : | P29466 |
Products Types
◆ Recombinant Protein | ||
CASP1-1265H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), Tag Free | +Inquiry |
Casp1-0413M | Active Recombinant Mouse Casp1 Protein | +Inquiry |
CASP1-0411H | Recombinant Human CASP1 Protein, GST-Tagged | +Inquiry |
CASP1-1266H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged | +Inquiry |
CASP1-621H | Recombinant Human CASP1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CASP1-7841HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
CASP1-7840HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionIt processes pro-inflammatory cytokines to their active forms, modulating inflammation.
Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).
It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.
CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.
Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.
Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.
CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.
Customer Reviews (3)
Write a reviewFast delivery, reliable results.
Very high-quality product.
Great for protein research.
Ask a Question for All CASP1 Products
Required fields are marked with *
My Review for All CASP1 Products
Required fields are marked with *
Inquiry Basket