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Recombinant Human CASP1 Protein, His-tagged

Cat.No. : CASP1-173H
Product Overview : Recombinant Human CASP1, transcript variant alpha, fused with His tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Source : E. coli
Species : Human
Tag : His
Form : 50mM Tris, 8M Urea, pH8.0.
Molecular Mass : 45 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CASP1 caspase 1, apoptosis-related cysteine peptidase [ Homo sapiens ]
Official Symbol : CASP1
Synonyms : CASP1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis related cysteine peptidase (interleukin 1, beta, convertase) , caspase 1, apoptosis related cysteine protease (interleukin 1, beta, convertase) , IL1BC; caspase-1; caspase 1; ICE; interleukin 1; beta; convertase; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); P45; IL1BC;
Gene ID : 834
mRNA Refseq : NM_001223
Protein Refseq : NP_150634
MIM : 147678
UniProt ID : P29466

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CASP1 contribute to the regulation of the inflammatory response? 08/06/2022

It processes pro-inflammatory cytokines to their active forms, modulating inflammation.

What therapeutic strategies are being explored targeting CASP1 for disease treatment? 02/13/2022

Therapeutic strategies include CASP1 inhibitors, aiming to reduce inflammation in diseases like cryopyrin-associated periodic syndromes (CAPS).

What role does CASP1 play in the maturation and secretion of pro-inflammatory cytokines? 06/07/2021

It is essential for the maturation and secretion of IL-1β and IL-18, pro-inflammatory cytokines.

In which cells or tissues is CASP1 predominantly expressed? 09/30/2019

CASP1 is predominantly expressed in immune cells like macrophages and dendritic cells.

Are there known genetic mutations in CASP1 associated with specific diseases? 09/09/2019

Genetic mutations in CASP1 have been associated with increased susceptibility to certain infectious and inflammatory diseases.

How is CASP1 implicated in the pathogenesis of autoinflammatory diseases? 04/03/2019

Dysregulation of CASP1 is linked to autoinflammatory diseases, causing excessive inflammation.

What is the primary biological function of CASP1 in cells? 07/26/2018

CASP1 is a protease that plays a critical role in the initiation of apoptosis and inflammation.

Customer Reviews (3)

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Reviews
09/14/2022

    Fast delivery, reliable results.

    01/21/2022

      Very high-quality product.

      07/28/2021

        Great for protein research.

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