CD6

  • Official Full Name

    CD6 Molecule

  • Overview

    CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation
  • Synonyms

    T-cell differentiation antigen CD6; T12; CD6 antigen; OTTHUMP00000236965; OTTHUMP00000236967; OTTHUMP00000236969; OTTHUMP00000236970; OTTHUMP00000236971; TP120; FLJ44171; CD6; CD6 molecule;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect cells
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • GST
  • hIgG
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD6-018H Recombinant Human CD6 protein, His-tagged HEK293 His His 18 - Glu 398
Human CD6-1591H Recombinant Human CD6 Molecule Mammalian cells N/A
Human CD6-27581TH Recombinant Human CD6 Wheat Germ N/A
Human CD6-312H Recombinant Human CD6 protein, His/T7-tagged E.coli His/T7
Human CD6-4759H Recombinant Human CD6 Molecule, His-tagged HEK293 His
Human CD6-0839H Recombinant Human CD6 Protein, GST-Tagged Wheat Germ GST
Human CD6-4760H Active Recombinant Human CD6 protein, hFc-tagged HEK293 hFc Met1-Glu398
Human CD6-05H Active Recombinant Human CD6 Protein, hIgG/His-tagged Insect cells hIgG/His
Human CD6-1495H Recombinant Human CD6 Protein (His18-Cys350), N-His tagged E.coli N-His His18-Cys350
Human CD6-4377H-B Recombinant Human CD6 Protein Pre-coupled Magnetic Beads HEK293
Human CD6-6883HF Recombinant Full Length Human CD6 Protein In Vitro Cell Free System 668 amino acids
Human CD6-174H Recombinant Human CD6 Protein, C-His-tagged E.coli C-His
Human CD6-4377H Recombinant Human CD6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD6-5299H Recombinant Human CD6 Protein (Met1-Glu398), C-Fc tagged Mammalian cells C-Fc Met1-Glu398
Mouse CD6-1240M Acitve Recombinant Mouse CD6 protein(Met1-Gly396), His-tagged HEK293 C-His Met1-Gly396
Mouse Cd6-5665M Recombinant Mouse Cd6 protein, His & T7-tagged E.coli His/T7 Gly30~Gly204 (Accession # Q61003)
Mouse Cd6-1710M Recombinant Mouse CD6 Antigen Mammalian cells N/A
Mouse Cd6-6896M Recombinant Mouse Cd6, His tagged Human Cell His
Mouse Cd6-5170M Active Recombinant Mouse Cd6 protein(Met1-Val243), hFc-tagged HEK293 C-hFc Met1-Val243
Mouse CD6-1807MCL Recombinant Mouse CD6 cell lysate Human Cell N/A
Mouse Cd6-10527M-B Recombinant Mouse Cd6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd6-10527M Recombinant Mouse Cd6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CD6-1144R Recombinant Rat CD6 protein(Met1-Asn396), His-tagged HEK293 C-His Met1-Asn396
Rat Cd6-31R Recombinant Rat Cd6, His tagged Human Cell Fc
Rat Cd6-5666R Recombinant Rat Cd6 protein, His & T7-tagged E.coli His/T7 Ser477~Pro644 (Accession # Q812A4)
Rat CD6-958RCL Recombinant Rat CD6 cell lysate Human Cell N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD6 involved in several pathways and played different roles in them. We selected most pathways CD6 participated on our site, such as Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD86;ITGB2L;SDC2;MADCAM1;BLA;BLB2;ITGAM;SELP;NLGN3A

CD6 has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD6 itself. We selected most functions CD6 had, and list some proteins which have the same functions with CD6. You can find most of the proteins on our site.

Function Related Protein
lipopolysaccharide bindingSCARB1;LBP;CATHL3;RNASE7;HMGB1;BPIFC;BPIFA2;CD14;TRIL
lipoteichoic acid bindingTLR2;CD14;LBP;TREM2;CD6
protein bindingNAV1;ZNF10;COLGALT2;NR4A3;IL12A;FANCB;CTBP1;PAK2;DLL1
scavenger receptor activityCD6;DMBT1;GM106;CXCL16;TMPRSS5;PRSS7;SRCRB4D;SCARA5;LGALS3BP

CD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD6.

Sdcbp; LGALS1; LGALS3; ALCAM; SDCBP; GYG1; NFE2L1; acnA

Research Area

Related articles

Budamakuntla, L; Madaiah, M; et al. Itolizumab provides sustained remission in plaque psoriasis: a 5-year follow-up experience. CLINICAL AND EXPERIMENTAL DERMATOLOGY 40:152-155(2015).
Wan, HQ; Yang, H; et al. Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers. NATURE COMMUNICATIONS 6:-(2015).
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  • Q&As

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      07/27/2019

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        Q&As (5)

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        Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses? 02/18/2022

        CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

        How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases? 07/19/2021

        CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

        How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process? 04/01/2020

        CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

        How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation? 09/28/2019

        CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

        What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses? 11/05/2018

        CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.

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