Recombinant Human CD6 protein, His/T7-tagged

Cat.No. : CD6-312H
Product Overview : Recombinant Human CD6(18-402 aa) fused with His/T7 tag at N-terminal was expressed in E. coli.
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Description : This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : His&T7
Form : Liquid
Molecular Mass : 44 kDa
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEFHPSPAPPDQLNTSSAESELWE PGERLPVRLTNGSSSCSGTVEVRLE ASWEPACGALWDSRAAEAVCRALGC GGAEAASQLAPPTPELPPPPAAGNT SVAANATLAGAPALLCSGAEWRLCE VVEHACRSDGRRARVTCAENRALRL VDGGGACAGRVEMLEHGEWGSVCDD TWDLEDAHVVCRQLGCGWAVQALPG LHFTPGRGPIHRDQVNCSGAEAYLW DCPGLPGQHYCGHKEDAGAVCSEHQ SWRLTGGADRCEGQVEVHFRGVWNT VCDSEWYPSEAKVLCQSLGCGTAVE RPKGLPHSLSGRMYYSCNGEELTLS NCSWRFNNSNLCSQSLAARVLCSAS RSLHNLSTPEVPASVQTVTIESSVT VKIENKESRELMLL
Purity : >90% by SDS-PAGE.
Applications : SDS-PAGE
Concentration : 50 µg at 0.5 mg/ml
Shipping : Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Protein length : 18-402
Gene Name : CD6 CD6 molecule [ Homo sapiens ]
Official Symbol : CD6
Synonyms : CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171;
Gene ID : 923
mRNA Refseq : NM_001254750
Protein Refseq : NP_001241679
MIM : 186720
UniProt ID : P30203
Chromosome Location : 11q12.2
Pathway : Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
Function : scavenger receptor activity;

Not For Human Consumption!

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04/05/2021

    Fantastic customer support. They genuinely care about the success of our research.

    11/11/2020

      Quality you can trust. Our lab has seen improved precision since using this product.

      07/27/2019

        Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

        Q&As (5)

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        Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses? 02/18/2022

        CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

        How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases? 07/19/2021

        CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

        How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process? 04/01/2020

        CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

        How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation? 09/28/2019

        CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

        What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses? 11/05/2018

        CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.

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