Recombinant Human CD6 protein, His/T7-tagged
Cat.No. : | CD6-312H |
Product Overview : | Recombinant Human CD6(18-402 aa) fused with His/T7 tag at N-terminal was expressed in E. coli. |
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Description : | This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His&T7 |
Form : | Liquid |
Molecular Mass : | 44 kDa |
AA Sequence : | MASMTGGQQMGRGHHHHHHGNLYFQ GGEFHPSPAPPDQLNTSSAESELWE PGERLPVRLTNGSSSCSGTVEVRLE ASWEPACGALWDSRAAEAVCRALGC GGAEAASQLAPPTPELPPPPAAGNT SVAANATLAGAPALLCSGAEWRLCE VVEHACRSDGRRARVTCAENRALRL VDGGGACAGRVEMLEHGEWGSVCDD TWDLEDAHVVCRQLGCGWAVQALPG LHFTPGRGPIHRDQVNCSGAEAYLW DCPGLPGQHYCGHKEDAGAVCSEHQ SWRLTGGADRCEGQVEVHFRGVWNT VCDSEWYPSEAKVLCQSLGCGTAVE RPKGLPHSLSGRMYYSCNGEELTLS NCSWRFNNSNLCSQSLAARVLCSAS RSLHNLSTPEVPASVQTVTIESSVT VKIENKESRELMLL |
Purity : | >90% by SDS-PAGE. |
Applications : | SDS-PAGE |
Concentration : | 50 µg at 0.5 mg/ml |
Shipping : | Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles. |
Protein length : | 18-402 |
Gene Name : | CD6 CD6 molecule [ Homo sapiens ] |
Official Symbol : | CD6 |
Synonyms : | CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171; |
Gene ID : | 923 |
mRNA Refseq : | NM_001254750 |
Protein Refseq : | NP_001241679 |
MIM : | 186720 |
UniProt ID : | P30203 |
Chromosome Location : | 11q12.2 |
Pathway : | Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; |
Function : | scavenger receptor activity; |
Products Types
◆ Lysates | ||
CD6-958RCL | Recombinant Rat CD6 cell lysate | +Inquiry |
CD6-1807MCL | Recombinant Mouse CD6 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewFantastic customer support. They genuinely care about the success of our research.
Quality you can trust. Our lab has seen improved precision since using this product.
Shipping is always on time, and the packaging ensures the product arrives in perfect condition.
Q&As (5)
Ask a questionCD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.
CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.
CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.
CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.
CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.
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