Recombinant Human CD6 Molecule, His-tagged

• Cat.No.: CD6-4759H
• Product Overview: CD6 was fused with a C-terminal 6 His tag and has a calculated MW of 68.2 KDa expressed. Protein migrates as 110 kDa in reduced SDS-PAGE resulting from glycosylation.

Specification

• Cat. No.: CD6-4759H
• Description: CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF). CD6 is expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 appears to play a role as both a costimulatory molecule in T cell activation and as an adhesion receptor. Studies demonstrating a mitogenic effect for T cells with some CD6 specific monoclonal antibodies, in conjunction with either accessory cells or PMA and antiCD2 mAb, support the concept of CD6 as a co stimulatory molecule.
• Source: Recombinant human CD6 /TP120 His18 -Glu398 (Accession Q8WWJ7) fused with a C-terminal His tag was produced in human HEK293 cells
• Species: Human
• Form: Bulk protein in a 0.22 μm filtered solution of PBS, pH7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Purity: >95% as determined by SDS-PAGE. All lots are greater than 95% pure.
• Endotoxin: Less than 1.0 EU per 1 μg of the rhCD6 by the LAL method.
• Storage: Store at -80°C upon received. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; TP120; FLJ44171; CD6 antigen; T-cell differentiation antigen CD6; T12; OTTHUMP00000236965; OTTHUMP00000236967; OTTHUMP00000236969; OTTHUMP00000236970; OTTHUMP00000236971
• Gene ID: 923
• mRNA Refseq: NM_006725
• Protein Refseq: NP_006716
• MIM: 186720
• UniProt ID: P30203
• Chromosome Location: 11q13
• Pathway: Cell adhesion molecules (CAMs)
• Function: scavenger receptor activity

Reviews

04/05/2021

Fantastic customer support. They genuinely care about the success of our research.

11/11/2020

Quality you can trust. Our lab has seen improved precision since using this product.

07/27/2019

Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

Q&As

Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses?

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases?

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process?

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation?

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses?

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.