Recombinant Human CD6

• Cat.No.: CD6-27581TH
• Product Overview: Recombinant Human CD6 was expressed in Wheat Germ.

Specification

• Description: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion mol
• Source: Wheat Germ
• Species: Human
• Form: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
• Molecular Mass: 68.9 kDa
• AA Sequence: MWLFFGITGLLTAALSGHPSPAPPD QLNTSSAESELWEPGERLPVRLTNG SSSCSGTVEVRLEASWEPACGALWD SRAAEAVCRALGCGGAEAASQLAPP TPELPPPPAAGNTSVAANATLAGAP ALLCSGAEWRLCEVVEHACRSDGRR ARVTCAENRALRLVDGGGACAGRVE MLEHGEWGSVCDDTWDLEDAHVVCR QLGCGWAVQALPGLHFTPGRGPIHR DQVNCSGAEAYLWDCPGLPGQHYCG HKEDA
• Applications: Antibody Production.Functional Study: Recommended usage only, not validated yet.Compound Screening: Recommended usage only, not validated yet.
• Notes: Heating may cause protein aggregation. Please do not heat this product before electrophoresis. Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Tag: Non

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171
• Gene ID: 923
• mRNA Refseq: NM_001254750
• Protein Refseq: NP_001241679
• MIM: 186720
• UniProt ID: P30203
• Chromosome Location: 11q12.2
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem
• Function: scavenger receptor activity

Reviews

04/05/2021

Fantastic customer support. They genuinely care about the success of our research.

11/11/2020

Quality you can trust. Our lab has seen improved precision since using this product.

07/27/2019

Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

Q&As

Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses?

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases?

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process?

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation?

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses?

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.