Recombinant Human CD6 Protein, C-His-tagged

• Cat.No.: CD6-174H
• Product Overview: Recombinant Human CD6 Protein with C-His tag was expressed in E. coli.

Specification

• Description: T cell differentiation antigen CD6 is a cell adhesion molecule expressed on immature thymocytes and mature T cells, and has also been detected on a subset of B cells and NK cells within the immune system. CD6 mediates cell-cell interactions through it’s binding partner CD166/ALCAM, and contributes to the formation and maturation of the immunological synapse. CD6 functions as a co-stimulatory receptor, promoting T cell activation and proliferation through the TCR/CD3 complex signaling cascade. Studies have shown CD6 can be glycosylated, hyperphosphorylated on serine and threonine residues, and phosphorylated on tyrosine residues, each of which can differentially effect the function and signaling of this molecule. CD6 also functions as a calcium-dependent pattern receptor that binds and aggregates Gram-positive and Gram-negative bacteria. In response to lipopolysaccharide, CD6 mediates activation of the inflammatory response and secretion of pro-inflammatory cytokines.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~42 kDa
• AA Sequence: HPSPAPPDQLNTSSAESELWEPGER LPVRLTNGSSSCSGTVEVRLEASWE PACGALWDSRAAEAVCRALGCGGAE AASQLAPPTPELPPPPAAGNTSVAA NATLAGAPALLCSGAEWRLCEVVEH ACRSDGRRARVTCAENRALRLVDGG GACAGRVEMLEHGEWGSVCDDTWDL EDAHVVCRQLGCGWAVQALPGLHFT PGRGPIHRDQVNCSGAEAYLWDCPG LPGQHYCGHKEDAGAVCSEHQSWRL TGGADRCEGQVEVHFRGVWNTVCDS EWYPSEAKVLCQSLGCGTAVERPKG LPHSLSGRMYYSCNGEELTLSNCSW RFNNSNLCSQSLAARVLCSASRSLH NLSTPEVPASVQTVTIESSVTVKIE NKESRELML
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens (human) ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171
• Gene ID: 923
• mRNA Refseq: NM_001254750
• Protein Refseq: NP_001241679
• MIM: 186720
• UniProt ID: P30203

Reviews

04/05/2021

Fantastic customer support. They genuinely care about the success of our research.

11/11/2020

Quality you can trust. Our lab has seen improved precision since using this product.

07/27/2019

Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

Q&As

Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses?

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases?

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process?

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation?

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses?

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.