Active Recombinant Human CD6 Protein, hIgG/His-tagged

• Cat.No.: CD6-05H
• Product Overview: Recombinant human CD6 protein (18-402aa), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cells
• Species: Human
• Tag: His&Fc
• Form: Liquid
• Bio-activity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When cells are added to human CD6 coated plates 10 μg/mL. This effect is more to 50 %.
• Molecular Mass: 68.3 kDa
• AA Sequence: HPSPAPPDQLNTSSAESELWEPGER LPVRLTNGSSSCSGTVEVRLEASWE PACGALWDSRAAEAVCRALGCGGAE AASQLAPPTPELPPPPAAGNTSVAA NATLAGAPALLCSGAEWRLCEVVEH ACRSDGRRARVTCAENRALRLVDGG GACAGRVEMLEHGEWGSVCDDTWDL EDAHVVCRQLGCGWAVQALPGLHFT PGRGPIHRDQVNCSGAEAYLWDCPG LPGQHYCGHKEDAGAVCSEHQSWRL TGGADRCEGQVEVHFRGVWNTVCDS EWYPSEAKVLCQSLGCGTAVERPKG LPHSLSGRMYYSCNGEELTLSNCSW RFNNSNLCSQSLAARVLCSASRSLH NLSTPEVPASVQTVTIESSVTVKIE NKESRELMLL
• Endotoxin: < 1 EU/μg of protein (determined by LAL method)
• Purity: 90% by SDS - PAGE
• Applications: SDS-PAGE, Bioactivity
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL
• Storage Buffer: In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• Protein length: 18-402

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens (human) ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; TP120; T-cell differentiation antigen CD6; CD6 antigen; T12
• Gene ID: 923
• mRNA Refseq: NM_006725
• Protein Refseq: NP_006716
• MIM: 186720
• UniProt ID: P30203

Reviews

04/05/2021

Fantastic customer support. They genuinely care about the success of our research.

11/11/2020

Quality you can trust. Our lab has seen improved precision since using this product.

07/27/2019

Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

Q&As

Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses?

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases?

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process?

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation?

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses?

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.