Recombinant Human CD6 protein, His-tagged

• Cat.No.: CD6-1650H
• Product Overview: Recombinant Human CD6 protein(NP_006716.3)(His18-Leu402), fused with C-terminal His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: His18-Leu402
• Form: Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
• Bio-activity: Immobilized Human CD6, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human ALCAM, hFc Tag with the EC50 of 5.6ng/ml determined by ELISA.
• Molecular Mass: The protein has a predicted MW of 42.14 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Tris-Bis PAGE result.
• Endotoxin: Less than 1EU per μg by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC.
• Storage: Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Reconstitution: Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; CD6 antigen; T-cell differentiation antigen CD6; Tp120; T12; TP120; FLJ44171
• Gene ID: 923
• mRNA Refseq: NM_001254750
• Protein Refseq: NP_001241679
• MIM: 186720
• UniProt ID: P30203

Reviews

04/05/2021

Fantastic customer support. They genuinely care about the success of our research.

11/11/2020

Quality you can trust. Our lab has seen improved precision since using this product.

07/27/2019

Shipping is always on time, and the packaging ensures the product arrives in perfect condition.

Q&As

Can you explain the role of CD6 in T-cell co-stimulation and its implications for adaptive immune responses?

CD6 provides co-stimulatory signals to T cells, influencing their activation and differentiation. This contributes to the regulation of adaptive immune responses.

How are CD6 genes polymorphic, and what is the significance of genetic variations in the context of autoimmune diseases?

CD6 genes exhibit polymorphisms, and certain variations are associated with susceptibility to autoimmune diseases, indicating a potential role in immune dysregulation.

How does CD6 contribute to the formation of immunological synapses, and what molecular events are involved in this process?

CD6 is involved in immunological synapse formation, and its interactions with ligands, such as ALCAM, play a role in stabilizing T-cell interactions with antigen-presenting cells.

How does CD6 influence T-cell trafficking and migration, and what are the implications for immune surveillance and inflammation?

CD6 modulates T-cell trafficking and migration, impacting immune surveillance and inflammation. Its interactions with adhesion molecules contribute to these processes.

What is the relationship between CD6 and antigen-presenting cells, and how does it impact the initiation of immune responses?

CD6 interacts with antigen-presenting cells, facilitating T-cell activation. This interaction is pivotal for the initiation and regulation of immune responses.