Recombinant Human IL31 Protein, StrepII-tagged

Cat.No. : IL31-284H
Product Overview : Recombinant human IL31 protein with StrepII-tag was expressed in HEK293
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Description : IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma.
Source : HEK293
Species : Human
Tag : StrepII
Molecular Mass : The protein has a calculated MW of 17 kDa.
AA Sequence : SHTLPVRLLRPSDDVQKIVEELQSL SKMLLKDVEEEKGVLVSQNYTLPCL SPDAQPPNNIHSPAIRAYLKTIRQL DNKSVIDEIIEHLDKLIFQDAPETN ISVPTDTHECKRFILTISQQFSECM DLALKSLTSGAQQATTWSHPQFEK
Endotoxin : <0.1 EU/μg
Purity : >80% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose
FACS: Reducing 12% SDS-PAGE and WB analysis profile of purified IL31<br />1. IL31<br />2. BSA
Gene Name : IL31 interleukin 31 [ Homo sapiens (human) ]
Official Symbol : IL31
Synonyms : IL31; interleukin 31; interleukin-31; IL 31; IL-31;
Gene ID : 386653
mRNA Refseq : NM_001014336
Protein Refseq : NP_001014358
MIM : 609509
UniProt ID : Q6EBC2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the advantages of IL31 compared with other therapeutic methods? 07/19/2022

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31? 09/26/2020

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory? 09/09/2020

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31? 01/02/2020

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31? 10/06/2019

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment? 01/01/2019

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.

Customer Reviews (3)

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04/22/2022

    IL31 product has strict quality control and complies with relevant industry standards.

    09/26/2021

      It performs well in biological activity tests.

      09/13/2020

        This protein has high yield and good economic benefits.

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