Recombinant Mouse Il31 Protein (Thr24-Cys163), C-His tagged, Animal-free, Carrier-free

• Cat.No.: Il31-293M
• Product Overview: Recombinant Mouse Il31 Protein (Thr24-Cys163) with C-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Description: Interleukin 31 (IL-31) is a 15.65 kDa cytokine with 141 amino acid residues. IL-31 is mainly secreted from Th2 cells and binds to a receptor called IL-31RA. Upon binding to IL-31RA, IL-31 activates several signal pathways like MAPK, PI3K/AKT, and Jak/STAT pathways. It is critical in regulating many biological functions, such as cell proliferation, hematopoiesis, induction of cytokines, inflammation, and immune response. It also responds to an antigen by facilitating cell-mediated immunity.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Molecular Mass: The protein has a calculated MW of 16.56 kDa.
  The protein migrates about 17 kDa under reducing condition (SDS-PAGE analysis).
• Protein Length: Thr24-Cys163
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >95% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.

Gene Information

• Gene Name: Il31 interleukin 31 [ Mus musculus (house mouse) ]
• Official Symbol: Il31
• Synonyms: IL31; interleukin 31; interleukin-31; IL-31; 1700013B14Rik
• Gene ID: 76399
• mRNA Refseq: NM_029594
• Protein Refseq: NP_083870
• UniProt ID: Q6EAL8

Reviews

04/22/2022

IL31 product has strict quality control and complies with relevant industry standards.

09/26/2021

It performs well in biological activity tests.

09/13/2020

This protein has high yield and good economic benefits.

Q&As

What are the advantages of IL31 compared with other therapeutic methods?

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31?

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory?

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31?

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31?

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment?

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.