Active Recombinant Human PCSK9 protein, Fc-tagged
|Product Overview :
|Recombinant Human PCSK9 protein(Gln31-Gln692), fused with Fc tag, was expressed in HEK293.
- Gene Information
- Related Products
|Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
|Immobilized Human VLDL R, His Tag at 5 μg/mL (100 μL/well) can bind Human PCSK9, Fc Tag with a linear range of 1-10 ng/mL. Immobilized Human PCSK9, Fc Tag at 5 μg/mL (100 μL/well) can bind Biotinylated Human LDL R, His Tag, Avi Tag with a linear range of 0.04-0.625 μg/mL.
|Molecular Mass :
|This protein carries a human IgG1 Fc tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‑covalent interactions and with a calculated MW of 13.8 kDa and 83.7 kDa respectively. The protein migrates as 16 kDa and 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
|Less than 1.0 EU per μg by the LAL method.
|>90% as determined by SDS-PAGE.
|Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
|It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
|Gene Name :
|PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens ]
|Official Symbol :
|PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3;
|Gene ID :
|UniProt ID :
|◆ Recombinant Protein
|Recombinant Rhesus Macaque PCSK9 Protein, His (Fc)-Avi-tagged
|Recombinant Cynomolgus monkey PCSK9 Protein, His-tagged
|Active Recombinant Human PCSK9 Protein, His-tagged
|Recombinant Rat PCSK9 Protein, His (Fc)-Avi-tagged
|Recombinant Mouse PCSK9 Protein, His-tagged(C-ter)
|Recombinant Human PCSK9 cell lysate
|Recombinant Mouse PCSK9 cell lysate
|Recombinant Rat PCSK9 cell lysate
|◆ Assay kits
|PCSK9[Biotinylated]-LDLR Binding Assay Kit
|PCSK9-LDLR TR-FRET Assay Kit
|PCSK9(D374T)-LDLR TR-FRET Assay Kit
|PCSK9-LDLR in vitro Binding Assay Kit
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
Yes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.
PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.
This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.
Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.
Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.
PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.
Customer Reviews (3)Write a review
In immunological experiments, it was found that it had good antigenicity and could induce target immune responses.
It promoted cell growth and proliferation.
High catalytic efficiency.
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