Recombinant Human PCSK9 (R194A) protein, His-tagged
Cat.No. : | PCSK9-289H |
Product Overview : | Recombinant Human PCSK9 (Gln31-Gln692, R194A) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3). |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Gln31 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | Human PCSK9 (R194A) has a calculated MW of 71.8 kDa. DTT-reduced Protein migrates as 17 kDa and 66 kDa in SDS-PAGE due to glycosylation and proteolytic digestion. The R194A mutation results in lower affinity of PCSK9 for LDLR. |
Protein length : | Gln31-Gln692 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | PCSK9 |
Official Symbol : | PCSK9 |
Synonyms : | FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3 |
Gene ID : | 353175 |
mRNA Refseq : | NM_174936.4 |
Protein Refseq : | NP_777596.2 |
MIM : | 607786 |
UniProt ID : | Q8NBP7 |
Products Types
◆ Recombinant Protein | ||
PCSK9-1257R | Acitve Recombinant Rat PCSK9 protein(Met1-Gln691), His-tagged | +Inquiry |
PCSK9-3273H | Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged, Biotinylated | +Inquiry |
PCSK9-264H | Recombinant Human PCSK9 Protein, His-tagged(C-ter) | +Inquiry |
PCSK9-411H | Recombinant Human PCSK9 Protein, Strep-tagged | +Inquiry |
PCSK9-13H | Recombinant Human CSK9 Protein (31-692), C-His-Avi-Tagged, Biotin-Labeled | +Inquiry |
◆ Lysates | ||
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-0666 | PCSK9-LDLR in vitro Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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