Recombinant Human PCSK9 protein, His-tagged
Cat.No. : | PCSK9-264H |
Product Overview : | Recombinant Human PCSK9 protein(Q8NBP7-1)(Gln31-Gln692), fused with C-terminal His tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | C-His |
Protein length : | Gln31-Gln692 |
Form : | Supplied as 0.22μm filtered solution in 20mM PB, 300mM NaCl, 10% glycerol (pH 7.4). |
Bio-activity : | Immobilized Human PCSK9, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-PCSK9 antibody, hFc Tag with the EC50 of 0.16μg/ml determined by ELISA. |
Molecular Mass : | Due to autocatalytic cleavage, the protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Tris-Bis PAGE result. |
Endotoxin : | Less than 1EU per μg by the LAL method. |
Purity : | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
Storage : | Valid for 12 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens ] |
Official Symbol : | PCSK9 |
Synonyms : | PCSK9; proprotein convertase subtilisin/kexin type 9; HCHOLA3, hypercholesterolemia, autosomal dominant 3; FH3; NARC 1; NARC1; NARC-1; HCHOLA3; |
Gene ID : | 353175 |
MIM : | 607786 |
UniProt ID : | Q8NBP7 |
Products Types
◆ Recombinant Protein | ||
PCSK9-804H | Recombinant Human PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-1622H | Recombinant Human PCSK9 Protein, His (Fc)-Avi-tagged | +Inquiry |
Pcsk9-265M | Recombinant Mouse PCSK9 Protein, His-tagged(C-ter) | +Inquiry |
PCSK9-414R | Recombinant Rhesus macaque PCSK9 Protein, His-tagged | +Inquiry |
PCSK9-184H | Active Recombinant Human PCSK9 protein(Met1-Gln692), His-tagged | +Inquiry |
◆ Lysates | ||
PCSK9-2564MCL | Recombinant Mouse PCSK9 cell lysate | +Inquiry |
PCSK9-2306RCL | Recombinant Rat PCSK9 cell lysate | +Inquiry |
PCSK9-2875HCL | Recombinant Human PCSK9 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1806 | PCSK9(D374T)-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1808 | PCSK9-LDLR TR-FRET Assay Kit | +Inquiry |
Kit-1807 | PCSK9[Biotinylated]-LDLR Binding Assay Kit | +Inquiry |
Kit-0665 | PCSK9-BIRC2 in vitro Binding Assay Kit | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewIn immunological experiments, it was found that it had good antigenicity and could induce target immune responses.
It promoted cell growth and proliferation.
High catalytic efficiency.
Q&As (6)
Ask a questionYes, some studies suggest that mutations in the PCSK9 protein gene may increase the risk of cardiovascular disease. For example, some PCSK9 mutations can cause their dysfunction, resulting in hypercholesterolemia and cardiovascular disease.
PCSK9 protein is combined with immune adjuvants to make a vaccine, or mutated PCSK9 protein to induce an immune response to it, inhibit PCSK9 expression in vivo, increase LDLR levels and reduce serum cholesterol levels.
This protein may have a regulatory effect on weight and obesity, and it is associated with glucose and endocannabinin homeostasis studies have linked PCSK9 to the development of obesity and diabetes.
Several new anti-PCSK9 drugs are already being studied and developed, including oral drugs and gene chromosome therapies, and some drugs have advanced to early stages of clinical trials, providing new options for the treatment of PCSK9 proteins.
Currently on the market to inhibit PCSK9 protein drugs include alirocumab and evolocumab.
PCSK9 protein can degrade LDLR protein, so its overexpression will lead to a decrease in LDLR's ability to be cleared, leading to hypercholesterolemia.
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