pdgfa
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  • Official Full Name
  • platelet-derived growth factor alpha polypeptide
  • Background
  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene
  • Synonyms
  • PDGFA; platelet-derived growth factor alpha polypeptide; PDGF1; PDGF-A; PDGF A-chain; platelet-derived growth factor alpha chain; Platelet-derived growth factor subunit A; PDGF subunit A; Platelet-derived growth factor A chain; PDGF-1; OTTHUMP00000199955; OTTHUMP00000199956; platelet-derived growth factor alpha isoform 2 preproprotein
Cat.#:PDGFA-1608HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein, GST-tagged
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Cat.#:PDGFA-514MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PDGFA Protein, His-tagged
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Cat.#:PDGFA-563HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFA Protein (Ser87-Thr211), His-tagged
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Cat.#:PDGFA-923CTag:His
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine PDGFA Protein (Ser87-Arg196), His-tagged
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Cat.#:PDGFA-940RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat PDGFA Protein (Ser87-Arg196), His-tagged
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Cat.#:Pdgfa-375RTag:N/A
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein
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Cat.#:PDGFA&PDGFB-17HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGF-AB
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Cat.#:PDGFA-047HTag:N/A
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human PDGFA Protein
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Cat.#:PDGFA-121HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-1609HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA, GST-tagged
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Cat.#:PDGFA-174HTag:His|S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein, His/S-tagged
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Cat.#:PDGFA-375HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Platelet-derived Growth Factor AA
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Cat.#:PDGFA-523HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-54HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA, His-tagged
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Cat.#:PDGFA-56HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PDGFAA
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Cat.#:PDGFA-57HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA protein
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Cat.#:Pdgfa-048MTag:N/A
Source (Host):HEK293 cellsSpecies:Mouse
Product nameRecombinant Mouse Pdgfa Protein
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Cat.#:PDGFA-12567MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFA Protein
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Cat.#:Pdgfa-175MTag:His|S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa protein, His/S-tagged
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Cat.#:Pdgfa-298MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Platelet Derived Growth Factor AA
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Cat.#:Pdgfa-304MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa
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Cat.#:Pdgfa-564MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdgfa protein, His-tagged
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Cat.#:Pdgfa&Pdgfb-216RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa&Pdgfb
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Cat.#:Pdgfa-176RTag:His|S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein, His/S-tagged
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Cat.#:Pdgfa-215RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa
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Cat.#:Pdgfa-2732RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pdgfa protein, His & T7-tagged
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Cat.#:PDGFA-4337RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDGFA Protein
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Cat.#:PDGFA-1044CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine PDGFA Protein, Fc-tagged
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Cat.#:PDGFA-5879CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFA
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Cat.#:PDGFA-101HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFA
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Cat.#:PDGFA-3337HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PDGFA 293 Cell Lysate
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Involved Pathway

Pdgfa involved in several pathways and played different roles in them. We selected most pathways Pdgfa participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pdgfa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK6; MAPK14B; CACNG4; CDC42L2; TAB2; RAF1B; CACNB2A; PRKCB; ARRB2; FGF8A
Ras signaling pathway
FGFR3; PDGFA; GNG12; ETS1; PLCE1; GRIN2A; NGF; PLA2G6; SHOC2; FGF12
Rap signaling pathway
ARAP3; PFN1; PLCB1; SIPA1L1; GNAS; NRAS; FGF17; CALM1; TLN1; VEGFC
Cytokine-cytokine receptor interaction
GDF5; CCL2; TNFSF8; GM2002; CXCR4B; PDGFAA; TNFRSF12A; CCL5; CCL3L1; INHBE
Phospholipase D signaling pathway
GRM5; CYTH3; Kitl; TSC2; RHOA; PLA2G4D; KRAS; AGPAT4; PLCB2; GRM6
PIK-Akt signaling pathway
GNG3; FASLG; HGF; GNG13; RPS6KB2; FGF22; SGK3; ITGB4; ATF4; FGF14
Focal adhesion
LAMC1; MYL2; THBS4A; ITGB4; COL5A2; AKT1; ITGA6B; PTK2AA; ROCK1; PRKCA
Gap junction
TUBA4A; PDGFD; MAPK1; MAP2K2B; ADRB3A; GNA15.4; PRKACA; TUBA1A; TUBB; PDGFC
Regulation of actin cytoskeleton
PDGFAA; PDGFAB; FGF6A; ITGAL; GNA12A; ARPC4L; FGF21; MAPK1; FGD1; FGF16
HTLV-I infection
IL6; HLA-B; TGFB1; NFATC2; CDC26; TNF; PDGFRA; PIK3R3; Adcy4; SLC25A31
Pathways in cancer
TRP53; LAMA1; CDC42; RAC1; ARNT; AGTR1A; GNAI1; NOS2; PLCB2; GNB3
Transcriptional misregulation in cancer
GRIA3; DDX5; REL; MEF2C; KLF3; HDAC2; FOXO1; ITGAM; ETV5; TLX1
MicroRNAs in cancer
Casp3; BMPR2; VEGFA; PIK3CA; CCNE2; BAK1; HRAS; BCL2; TGFB2; WNT3
Glioma
PIK3CA; MAP2K2; PRKCA; PIK3CD; PDGFB; PDGFA; SOS1; TRP53; CALM3; RB1
Prostate cancer
NDRG1; TGFA; MAP4K1; CREB3L2; CREB5; PDGFRB; FGFR1; TCF7L2; PIK3R5; PIK3CG
Melanoma
MDM2; MAPK3; PIK3R5; PIK3CG; FGF6; PIK3CA; RB1; PDGFRB; FGF21; FGF17
Choline metabolism in cancer
PDGFRA; MAPK8; TSC1; DGKZ; PLD1; FOS; WASF2; PLD2; SOS1; PDPK1

Protein Function

Pdgfa has several biochemical functions, for example, collagen binding, growth factor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pdgfa itself. We selected most functions Pdgfa had, and list some proteins which have the same functions with Pdgfa. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein CTSB; FN1; SERPINH1B; CTSL1; ITGA9; ITGA3; USH2A; CTSS; RELL2; CD44
Function growth factor activity
Related Protein Kitl; BMP2B; GPR19; GRN; PDGFD; CXCL1; INHBE; FGF8B; VEGFAA; THBS4
Function platelet-derived growth factor binding
Related Protein Pdgfa&Pdgfb; PDGFA; COL4A1; COL2A1; PDGFRB; COL1A1; COL5A1; PDGFRA; COL1A2; COL3A1
Function platelet-derived growth factor receptor binding
Related Protein PTPRJ; PDGFB; PDGFRB; PTEN; LYN; PDGFAB; PDGFA; TYMP; PDGFAA; Pdgfa&Pdgfb
Function protein binding
Related Protein CD164; RABGEF1; CCDC64; UBE2D1; MIB1; GORAB; YEATS4; C11orf57; ERBB3; PAN2
Function protein heterodimerization activity
Related Protein H2AFV; HIST4H4; APITD1; HIST1H2AK; PAFAH1B2; LIMK1; TCF3B; CD3G; TAF4B; HIST1H2BH
Function protein homodimerization activity
Related Protein CTSE; EEA1; TRPM8; ERBB3; TPR; PTPRO; GOT2; PDE2A; PVRL2; BOK

Interacting Protein

Pdgfa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pdgfa here. Most of them are supplied by our site. Hope this information will be useful for your research of Pdgfa.
PDGFRA; PDGFRB; PDGFB

Pdgfa Related Articles

Miro, L; Perez-Bosque, A; et al. Vasopressin regulation of epithelial colonic proliferation and permeability is mediated by pericryptal platelet-derived growth factor A. EXPERIMENTAL PHYSIOLOGY 99:1325-1334(2014).
Miller, JD; Benjamin, JT; et al. Chorioamnionitis stimulates angiogenesis in saccular stage fetal lungs via CC chemokines. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 298:L637-L645(2010).