s100a8

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s100a8

Official Full Name S100 calcium binding protein A8
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]
Synonyms S100A8; S100 calcium binding protein A8; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; protein S100-A8; MRP-8; calgranulin A; calgranulin-A; cystic fibrosis antigen; calprotectin L1L subunit; urinary stone protein band A; leukocyte L1 complex light chain; migration inhibitory factor-related protein 8; S100 calcium-binding protein A8 (calgranulin A);
    • Species :
    • Cattle
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Yeast
    • Tag :
    • GST
    • His
    • Flag
    • S
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human S100A8-1013H Recombinant Human Calprotectin Protein E.coli His
    Mouse S100A8-1510M Recombinant Mouse S100A8 Protein (2-89 aa), His-tagged Yeast His
    Rat S100A8-1511R Recombinant Rat S100A8 Protein (2-89 aa), His-tagged Yeast His
    Human S100A8-320H Recombinant Human S100A8 protein E.coli
    Human S100A8 & S100A9-2217H Recombinant Human S100A8 & S100A9 Heterodimer Protein, His & Flag tagged Insect Cell His/Flag
    Human S100A8-2216H Recombinant Human S100A8, His tagged Insect Cell His
    Human S100A8-226H Recombinant Human S100A8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human S100A8-2492H Recombinant Human S100A8, GST-tagged E.coli GST
    Human S100A8-294H Recombinant Human S100A8 Protein, MYC/DDK-tagged HEK293 N/A
    Human S100A8-3732H Recombinant Human S100A8, His-tagged E.coli His
    Human S100A8-432H Recombinant Human S100A8 protein E.coli N/A
    Human S100A8-685HCL Recombinant Human S100A8 cell lysate Insect Cell N/A
    Mouse S100A8-14622M Recombinant Mouse S100A8 Protein Mammalian Cell His
    Mouse S100a8-3545M Recombinant Mouse S100a8, His-tagged E.coli His
    Mouse S100a8-405M Recombinant Mouse S100a8, His tagged E.coli His
    Mouse S100a8-5107M Recombinant Mouse S100 Calcium Binding Protein A8 (calgranulin A), His-tagged Mouse His
    Rat S100a8-1361R Recombinant Rat S100a8 Protein, His-tagged E.coli His
    Rat S100a8-1803R Recombinant Rat S100a8 protein, His & T7-tagged E.coli His/T7
    Rat S100A8-5215R Recombinant Rat S100A8 Protein Mammalian Cell His
    Rhesus Macaque S100A8-4064R Recombinant Rhesus monkey S100A8 Protein, His-tagged Mammalian Cell His
    Rabbit S100A8-1804R Recombinant Rabbit S100A8 protein, His & T7-tagged E.coli His/T7
    Cattle S100A8-1801C Recombinant Cattle S100A8 protein, His & S-tagged E.coli His/S
    Pig S100A8-1802P Recombinant Pig S100A8 protein, His & T7-tagged E.coli His/T7

    s100a8 involved in several pathways and played different roles in them. We selected most pathways s100a8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with s100a8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    s100a8 has several biochemical functions, for example, RAGE receptor binding, Toll-like receptor 4 binding, arachidonic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by s100a8 itself. We selected most functions s100a8 had, and list some proteins which have the same functions with s100a8. You can find most of the proteins on our site.

    Function Related Protein
    RAGE receptor binding S100P; HMGB2; S100A7; HMGB1; S100A8; FPR1; S100A4; S100A9; S100B; S100A13
    Toll-like receptor 4 binding S100A8; S100A9; SAA3; TIRAP
    arachidonic acid binding ALOX5AP; S100A9; CYP4A14; STX3; PPARG; S100A8; CYP4F14
    calcium ion binding EPDR1; TTYH1; FBLN2; ANXA6; PVALB6; EHD3; EPS15L1; CALM; MYLPF; CASQ1B
    microtubule binding KIFC2; MAPRE3B; CHP; TXNDC3; NEFM; DCX; HDAC6; POLB; GABARAP; SPAST
    protein binding OTUD7B; TUFT1; PPFIA1; FCGR2B; NCAM1A; TESK2; KCNG4; KDM2B; RNF2; TRIM17
    zinc ion binding DUSP12; CA8; NPLOC4; BHMT; RECQL4; CPB1; TRIM69; QPCTL; ZDHHC5; NR1D2

    s100a8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with s100a8 here. Most of them are supplied by our site. Hope this information will be useful for your research of s100a8.

    S100A9; GAPDH; ESR1; NOS2; PPP2R2B

    Leal, RF; Planell, N; et al. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNF alpha therapy. GUT 64:233-242(2015).
    Obry, A; Lequerre, T; et al. Identification of S100A9 as Biomarker of Responsiveness to the Methotrexate/Etanercept Combination in Rheumatoid Arthritis Using a Proteomic Approach. PLOS ONE 9:-(2014).

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